INT86790

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Context Info
Confidence 0.74
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 14.04
Pain Relevance 15.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (P2rx6)
Anatomy Link Frequency
neurons 4
microglia 3
trigeminal ganglion 2
neuroblasts 2
nerve 2
P2rx6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 86 100.00 Very High Very High Very High
agonist 43 100.00 Very High Very High Very High
nociceptor 16 100.00 Very High Very High Very High
Calcitonin gene-related peptide 6 100.00 Very High Very High Very High
dorsal root ganglion 16 99.98 Very High Very High Very High
Dorsal horn 44 99.96 Very High Very High Very High
antinociception 6 99.96 Very High Very High Very High
trigeminal ganglion 32 99.84 Very High Very High Very High
Peripheral nerve injury 27 99.84 Very High Very High Very High
Spinal cord 109 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 57 99.98 Very High Very High Very High
Neurodegenerative Disease 166 99.56 Very High Very High Very High
Hyperalgesia 13 99.54 Very High Very High Very High
Death 26 99.52 Very High Very High Very High
Nervous System Injury 97 99.40 Very High Very High Very High
Pain 106 99.34 Very High Very High Very High
Neuropathic Pain 203 99.20 Very High Very High Very High
INFLAMMATION 49 99.00 Very High Very High Very High
Urological Neuroanatomy 12 98.96 Very High Very High Very High
Nociception 72 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After treatment with TMP, P2X3-receptor expression of the nerve terminal in the first- and second-degree dorsal burns of the TMP treatment group was significantly decreased.
Gene_expression (expression) of P2X3-receptor in dorsal
1) Confidence 0.74 Published 2010 Journal Burns Section Body Doc Link 19726132 Disease Relevance 0 Pain Relevance 0
On day 3 after the burn, P2X3-receptor expression in the nerve terminal in the burn-injured skin of the first- and second-degree dorsal burns in the NS treatment group was higher than those in other groups (p<0.05).
Gene_expression (expression) of P2X3-receptor in skin
2) Confidence 0.74 Published 2010 Journal Burns Section Body Doc Link 19726132 Disease Relevance 0 Pain Relevance 0
The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured, and P2X3 receptor expression on nerve terminals in burn-injured skin were detected by immunohistochemistry.
Gene_expression (expression) of P2X3 receptor in skin
3) Confidence 0.74 Published 2010 Journal Burns Section Body Doc Link 19726132 Disease Relevance 0.09 Pain Relevance 0
The P2X subtype of the ATP receptor is expressed in rat dorsal root ganglion (DRG) cells, spinal cord dorsal horn, and axons in peripheral tissues.
Gene_expression (expressed) of ATP receptor in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, dorsal horn and spinal cord
4) Confidence 0.62 Published 2005 Journal Cell Tissue Res. Section Abstract Doc Link 15902498 Disease Relevance 0.56 Pain Relevance 0.46
We reported previously that intracerebroventricular (i.c.v.) administration of P2X-receptor agonists produced antinociception and the effect was attenuated by i.c.v. pretreatment with beta(2)-adrenergic receptor antagonists.
Gene_expression (produced) of P2X-receptor associated with antinociception, antagonist, agonist and intracerebroventricular
5) Confidence 0.56 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978353 Disease Relevance 0 Pain Relevance 0.66
The superficial layers of the spinal cord dorsal horn (DH) express P2X2, P2X4, and P2X6 subunits entering into the formation of ionotropic (P2X) receptors for ATP.
Gene_expression (express) of P2X6 in spinal cord dorsal horn associated with dorsal horn and spinal cord
6) Confidence 0.51 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10704486 Disease Relevance 0 Pain Relevance 0.37
Simultaneously with glia activation, hyperalgesia was observed, but the expression of P2X4 receptor, which is considered to be closely associated with hyperalgesia, on microglia was not detected.
Gene_expression (expression) of P2X4 receptor in microglia associated with hyperalgesia
7) Confidence 0.50 Published 2005 Journal Neuroreport Section Abstract Doc Link 16110278 Disease Relevance 0.20 Pain Relevance 0.32
Microglia that were cultured on fibronectin-coated dishes showed a marked increase in P2X4 receptor expression, both at the mRNA and protein levels, as compared to those cultured on control dishes.
Gene_expression (expression) of P2X4 receptor in Microglia
8) Confidence 0.43 Published 2006 Journal Glia Section Abstract Doc Link 16534777 Disease Relevance 0.80 Pain Relevance 0.49
Here, we describe the influence of fibronectin on P2X4 receptor expression in microglia and the upregulation of fibronectin after peripheral nerve injury.
Gene_expression (expression) of P2X4 receptor in microglia associated with nervous system injury and peripheral nerve injury
9) Confidence 0.43 Published 2006 Journal Glia Section Abstract Doc Link 16534777 Disease Relevance 0.77 Pain Relevance 0.42
OGD induced the expression of P2X1 and P2X6 in cortical neuroblasts, while inhibiting P2X6 expression in the SVZ.
Gene_expression (expression) of P2X6 in neuroblasts
10) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.20 Pain Relevance 0.03
PPADS added during OGD inhibited the expression of P2X1 and P2X6, but not P2X7.
Gene_expression (expression) of P2X6
11) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.23 Pain Relevance 0.04
OGD induced the expression of P2X1 and P2X6 in cortical neuroblasts, while inhibiting P2X6 expression in the SVZ.
Gene_expression (expression) of P2X6 in neuroblasts
12) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.21 Pain Relevance 0.03
For the upregulation of P2X receptor expression, growth factors could be candidates.
Gene_expression (expression) of P2X receptor
13) Confidence 0.40 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.67 Pain Relevance 0.51
Although microglial P2X4 receptor expression is increased after peripheral nerve injury, the molecular mechanism(s) underlying its upregulation remains largely unknown.
Gene_expression (expression) of P2X4 receptor in peripheral nerve associated with nervous system injury and peripheral nerve injury
14) Confidence 0.37 Published 2006 Journal Glia Section Abstract Doc Link 16534777 Disease Relevance 0.68 Pain Relevance 0.34
P2X receptor antagonism by 100 µM PPADS during OGD led to a peak in SDf-1?
Gene_expression (antagonism) of P2X receptor
15) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.10 Pain Relevance 0.07
The results showed (1) pain thresholds were decreased while P2X3 receptor expression was up-regulated in the lateral PAG (lPAG) when neuropathic pain occurred.
Gene_expression (expression) of P2X3 receptor in lateral associated with pain, neuropathic pain and central grey
16) Confidence 0.34 Published 2010 Journal Brain Res. Section Abstract Doc Link 20302849 Disease Relevance 1.12 Pain Relevance 1.36
Conversely, the down-regulated P2X3 receptor expression in the lPAG with antisense oligodeoxynucleotide (ODN) for P2X3 gene significantly attenuated the antinociceptive effect of EA treatment.
Gene_expression (expression) of P2X3 receptor associated with electroacupuncture and antinociceptive
17) Confidence 0.34 Published 2010 Journal Brain Res. Section Abstract Doc Link 20302849 Disease Relevance 1.16 Pain Relevance 1.53
Furthermore, the phosphorylated ERK-positive neurons co-expressed the P2X3 receptor, and the injection of TNP-ATP, which antagonizes P2X receptors, into the inflamed joint reduced the phosphorylated ERK and the struggle behavior.
Gene_expression (co-expressed) of P2X3 receptor in neurons
18) Confidence 0.27 Published 2006 Journal Pain Section Abstract Doc Link 16616417 Disease Relevance 0.97 Pain Relevance 0.58
In this study, with neuropathic pain model of Sprague-Dawley (SD) rats, the P2X3 receptor protein level and expression location in the midbrain periaqueductal gray (PAG), a crucial site in endogenous pain modulatory system, were evaluated by Western blotting and immunohistochemistry.
Gene_expression (expression) of P2X3 receptor in midbrain associated with pain, neuropathic pain, midbrain and central grey
19) Confidence 0.26 Published 2010 Journal Brain Res. Section Abstract Doc Link 20302849 Disease Relevance 1.02 Pain Relevance 1.19
Among the P2X receptors, P2X2, P2X4, and P2X6 seem to be most abundantly expressed in the brain, whereas other subunits show more restricted localization [60–63].
Gene_expression (expressed) of P2X6 in brain
20) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.08 Pain Relevance 0

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