INT86799

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 6.22
Pain Relevance 5.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleolus (Pck1) nucleus (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
liver 4
muscle 2
hepatocytes 1
External 1
adrenal glands 1
Pck1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Immobilon 7 100.00 Very High Very High Very High
Opioid 244 99.84 Very High Very High Very High
Kinase C 36 98.84 Very High Very High Very High
Bile 129 97.92 Very High Very High Very High
Morphine 9 97.88 Very High Very High Very High
antagonist 80 94.64 High High
tolerance 2 93.40 High High
agonist 36 93.00 High High
medulla 102 86.20 High High
narcan 51 79.76 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 782 99.64 Very High Very High Very High
Fistula 38 97.52 Very High Very High Very High
Targeted Disruption 69 96.32 Very High Very High Very High
Repression 8 93.08 High High
Necrosis 9 89.20 High High
Body Weight 8 79.52 Quite High
Cirrhosis 8 78.96 Quite High
Nociception 24 63.36 Quite High
Pruritus 6 61.48 Quite High
Pain 20 61.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resolution of two [(35)S]GTP-gamma-S binding sites and their response to chronic morphine treatment: a binding surface analysis.
Gene_expression (Resolution) of GTP associated with immobilon and morphine
1) Confidence 0.65 Published 2000 Journal Brain Res. Bull. Section Title Doc Link 10704787 Disease Relevance 0 Pain Relevance 0.86
In conclusion, our results provide novel mechanisms for the plasma glucose-lowering action of metformin, via an increase of beta-endorphin secretion from adrenal glands to stimulate opioid mu-receptor linkage, leading to an increase of GLUT-4 gene expression and an attenuation of hepatic PEPCK gene expression in STZ-induced diabetic rats.
Gene_expression (expression) of PEPCK gene in adrenal glands associated with diabetes mellitus and opioid
2) Confidence 0.58 Published 2006 Journal Diabetes Section Abstract Doc Link 16505249 Disease Relevance 0.73 Pain Relevance 0.30
In the preliminary experiments, tetrandrine was found to significantly modify mRNA and protein levels of glucose transporters subtype 4 (GLUT4) and hepatic phosphoenolpyruvate carboxykinase (PEPCK) in STZ-diabetic rats after a 3-day treatment.
Gene_expression (levels) of PEPCK associated with diabetes mellitus
3) Confidence 0.53 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.26 Pain Relevance 0.04
The expressed protein of GLUT4 or PEPCK was characterized by Western blotting analysis.
Gene_expression (expressed) of PEPCK
4) Confidence 0.53 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC516459 Disease Relevance 0.61 Pain Relevance 0.18
-receptors to regulate the hepatic PEPCK gene expression need to be clarified in the future.
Gene_expression (expression) of PEPCK gene
5) Confidence 0.53 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.36 Pain Relevance 0.31
The addition of TCA or insulin to primary hepatocytes resulted in the rapid phosphorylation of FOX01, a key transcription factor controlling PEPCK and G-6-Pase gene expression (Fig. 4).
Gene_expression (expression) of PEPCK in hepatocytes
6) Confidence 0.51 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.31 Pain Relevance 0.21
and FOX01 to inhibit PEPCK and G-6-Pase gene expression (24, 28).
Gene_expression (expression) of PEPCK
7) Confidence 0.51 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.29
Opioid mu-receptor activation is held responsible for the enhancement of muscle GLUT 4 gene expression and the attenuation of hepatic PEPCK gene expression observed in these myricetin-treated diabetic animals.
Gene_expression (expression) of PEPCK gene in muscle associated with diabetes mellitus and opioid
8) Confidence 0.50 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203117 Disease Relevance 0.32 Pain Relevance 0.48
Injection of myricetin three times daily for three consecutive days resulted in increased expression of the glucose transporter subtype 4 (GLUT 4) in soleus muscle and in reduced expression of phosphoenolpyruvate carboxykinase (PEPCK) in liver; these inductions were preventable by opioid mu-receptor blockade.
Gene_expression (expression) of PEPCK in muscle associated with opioid
9) Confidence 0.50 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203117 Disease Relevance 0.38 Pain Relevance 0.52
In the present study, the enhanced gene expression of PEPCK resulting in increases in mRNA and protein levels in diabetic rats was suppressed by a 3-day repeated treatment with tetrandrine.
Gene_expression (expression) of PEPCK associated with diabetes mellitus
10) Confidence 0.47 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.19 Pain Relevance 0.35
Since gene expression of PEPCK in liver is regulated by a number of hormones (36), further experiments are necessary to identify the hormones involved in the effect of tetrandrine on the hepatic gene expression of PEPCK.
Gene_expression (expression) of PEPCK in liver
11) Confidence 0.47 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.27 Pain Relevance 0.35
Since gene expression of PEPCK in liver is regulated by a number of hormones (36), further experiments are necessary to identify the hormones involved in the effect of tetrandrine on the hepatic gene expression of PEPCK.
Gene_expression (expression) of PEPCK in liver
12) Confidence 0.47 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.17 Pain Relevance 0.42
In fact, it has been mentioned that signals for insulin to inhibit PEPCK expression did not mediate through the PKC pathways (36).
Gene_expression (expression) of PEPCK associated with kinase c
13) Confidence 0.47 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.34 Pain Relevance 0.30
Treatment of STZ-diabetic rats with andrographolide resulted in the reduced expression of phosphoenolpyruvate carboxykinase (PEPCK) in liver and an increased expression of the glucose transporter subtype 4 (GLUT 4) in soleus muscle.
Gene_expression (expression) of PEPCK in liver associated with diabetes mellitus
14) Confidence 0.43 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18080810 Disease Relevance 0.70 Pain Relevance 0.69
One behavioral mutant of Paramecium that lacks the Ca2+-dependent Na+ conductance (fast-2), only shows GTP-CCR in Mg2+-containing solutions and not in Na+ solutions (because it has the necessary Mg2+ conductance) while another mutant that lacks the Ca2+-dependent Mg2+ conductance (eccentric) only produces GTP-CCR in Na+-containing solutions and not in Mg2+-containing solutions [7].
Gene_expression (produces) of GTP-CCR
15) Confidence 0.18 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0
External binding of ATP and GTP
Gene_expression (External) of GTP in External
16) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0
Genetic dissection of the GTP response in Paramecium
Gene_expression (response) of GTP
17) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0
Model for chemosensory transduction of ATP and GTP signals
Gene_expression (transduction) of GTP
18) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0.13
While ATP only elicits AR, GTP also produces a longer response in Paramecium called continuous ciliary reversal (CCR) [6].
Gene_expression (produces) of GTP in ciliary
19) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0.12 Pain Relevance 0.09
ATP, GTP and their non-hydrolyzable analogs produce AR in Tetrahymena in a concentration-dependent manner and this can be quantitated by using the AR assay (Figure 1A).
Gene_expression (produce) of GTP
20) Confidence 0.14 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0.36 Pain Relevance 0.15

General Comments

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