INT86800

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (CALCRL) endosome (CALCRL) endoplasmic reticulum (CALCRL)
plasma membrane (CALCRL) lysosome (CALCRL) signal transducer activity (CALCRL)
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 16 100.00 Very High Very High Very High
agonist 10 95.44 Very High Very High Very High
Sumatriptan 1 94.08 High High
Central nervous system 1 88.48 High High
antagonist 2 88.20 High High
Opioid 2 75.00 Quite High
Analgesic 1 75.00 Quite High
Potency 1 68.16 Quite High
Glutamate 11 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 35 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Multiple System Atrophy 4 5.00 Very Low Very Low Very Low
Hypercalcemia 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Diabetes Insipidus 1 5.00 Very Low Very Low Very Low
Chondrodysplasia 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only a few different classes of structures are currently known as ligands for the GABA recognition site on the hetero-pentameric GABA(A) receptor complex, reflecting the very strict structural requirements for GABA(A) receptor recognition and activation.
Positive_regulation (requirements) of ) receptor Binding (recognition) of associated with gaba
1) Confidence 0.37 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451401 Disease Relevance 0 Pain Relevance 0.83
The present data suggest a role for the C-terminal intracellular receptor domain in modifying ketanserin/5-HT(1B) receptor interactions.
Positive_regulation (role) of receptor Binding (interactions) of
2) Confidence 0.27 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10704941 Disease Relevance 0 Pain Relevance 0.18
In vertebrate INSL3/relaxin binding GPCRs, a combination of a single cysteine-rich LDL-A domain and multiple LRRs at the ectodomain site is necessary for ligand binding, receptor activation and further downstream signalling from these receptors [45].
Positive_regulation (necessary) of receptor Binding (binding) of
3) Confidence 0.03 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0 Pain Relevance 0

General Comments

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