INT86805

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Context Info
Confidence 0.71
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 49
Total Number 50
Disease Relevance 28.48
Pain Relevance 6.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (HGF) extracellular space (HGF) extracellular region (HGF)
cell morphogenesis (HGF)
Anatomy Link Frequency
HGF 18
hepatocyte 9
liver 2
platelet 2
heart 2
HGF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 299 100.00 Very High Very High Very High
rheumatoid arthritis 240 100.00 Very High Very High Very High
chemokine 29 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
Neurotransmitter 2 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
COX2 17 99.80 Very High Very High Very High
fibrosis 33 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 242 100.00 Very High Very High Very High
Myocardial Infarction 151 100.00 Very High Very High Very High
Coronary Artery Disease 26 100.00 Very High Very High Very High
Fibrosis 23 99.68 Very High Very High Very High
Hiv-narrow Range Search Term 640 99.64 Very High Very High Very High
Malignant Neoplastic Disease 25 99.64 Very High Very High Very High
Chronic Disease 17 99.26 Very High Very High Very High
Keloid Scars 142 99.04 Very High Very High Very High
Obesity 45 98.82 Very High Very High Very High
Apoptosis 222 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the PCR screen IDO enzyme activity levels and secretion levels of HGF and COX2 generated PGE2 was evaluated in supernatants of primed/unprimed MSCs.
Localization (secretion) of HGF in HGF associated with cox2
1) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.07 Pain Relevance 0.10
Accordingly, it inhibited PGE2 and HGF release. 2.
Localization (release.) of HGF in HGF
2) Confidence 0.70 Published 2003 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 12925150 Disease Relevance 0 Pain Relevance 0
[Hepatocyte growth factor (HGF) in stable and unstable coronary heart disease].
Localization (disease) of Hepatocyte growth factor in heart associated with coronary artery disease
3) Confidence 0.70 Published 2003 Journal Pol. Arch. Med. Wewn. Section Title Doc Link 16736998 Disease Relevance 1.32 Pain Relevance 1.18
[Hepatocyte growth factor (HGF) in stable and unstable coronary heart disease].
Localization (disease) of HGF in heart associated with coronary artery disease
4) Confidence 0.70 Published 2003 Journal Pol. Arch. Med. Wewn. Section Title Doc Link 16736998 Disease Relevance 1.32 Pain Relevance 1.18
In particular, HGF secretion by those cells is sharply reduced compared to normal lung fibroblasts and they poorly respond to exogenously added KGF (Plantier et al 2005).
Localization (secretion) of HGF in HGF
5) Confidence 0.67 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.88 Pain Relevance 0
Interestingly, adipose-tissue derived stromal cells secrete particularly high levels of HGF.
Localization (secrete) of HGF in stromal cells
6) Confidence 0.67 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.44 Pain Relevance 0
Secreted levels of HGF and PGE2 was quantified using cytokine ELISA kits from R&D Systems according to the kit protocols.


Localization (Secreted) of HGF in HGF associated with cytokine
7) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0 Pain Relevance 0.20
priming of WJMSCs resulted in marked reduction of HGF secretion.
Localization (secretion) of HGF in HGF
8) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.09 Pain Relevance 0.09
A drastic difference in HGF secretion as well as transcript levels was observed in both the MSCs (Figure 5A, B).
Localization (secretion) of HGF in HGF
9) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.08 Pain Relevance 0.10
CONCLUSION: There is an enhanced secretion of cardiac HGF in the patients with severe coronary artery disease.
Localization (secretion) of HGF in HGF
10) Confidence 0.62 Published 2007 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 17785064 Disease Relevance 0 Pain Relevance 0
UFH promotes the release of serum HGF in the patients with chronic unstable angina pectoris undergoing PCI, which indicates some other biological effects in addition to its anticoagulant property.
Localization (release) of HGF in HGF
11) Confidence 0.62 Published 2007 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 17785064 Disease Relevance 0 Pain Relevance 0
These agents also inhibited H. pylori-induced HGF release.
Localization (release) of HGF in HGF
12) Confidence 0.57 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10807402 Disease Relevance 0.19 Pain Relevance 0
Hepatocyte growth factor is secreted by vascular endothelial cells and smooth muscle cells, and the hepatocyte growth factor receptor, c-met, was also observed in these vascular cells.
Localization (secreted) of Hepatocyte growth factor in Hepatocyte
13) Confidence 0.54 Published 2005 Journal Expert Rev Cardiovasc Ther Section Abstract Doc Link 15889978 Disease Relevance 0.12 Pain Relevance 0
BMMC and MSC have been extensively studied and proved to produce and secrete a broad variety of cytokines, chemokines, and growth factors, between them VEGF, FGF, HGF, IGF, adrenomedullin, thymosin ?
Localization (secrete) of HGF in HGF associated with chemokine and cytokine
14) Confidence 0.54 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2975079 Disease Relevance 0.08 Pain Relevance 0.10
However. the precise mechanism responsible for VEGF and HGF release in patients with coronary artery disease is still unknown.
Localization (release) of HGF in coronary artery associated with coronary artery disease
15) Confidence 0.52 Published 2000 Journal Heart Vessels Section Abstract Doc Link 11289497 Disease Relevance 0.88 Pain Relevance 0.23
Malignant plasma cells can secrete various cytokines, including VEGF, basic fibroblast growth factor (bFGF), and hepatocyte growth factor (HGF), all known for their pro-angiogenic activity [42].
Localization (secrete) of hepatocyte growth factor in HGF associated with malignant neoplastic disease and cytokine
16) Confidence 0.51 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.47 Pain Relevance 0.05
Malignant plasma cells can secrete various cytokines, including VEGF, basic fibroblast growth factor (bFGF), and hepatocyte growth factor (HGF), all known for their pro-angiogenic activity [42].
Localization (secrete) of HGF in HGF associated with malignant neoplastic disease and cytokine
17) Confidence 0.51 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.48 Pain Relevance 0.05
The simultaneous presence of FOXF1, VCAM1, and HGF in colon and urinary tract SMC gene clusters (Figure 4D) suggests that their regulatory relationship may be preserved in these SMCs.
Localization (presence) of HGF in HGF
18) Confidence 0.50 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.15 Pain Relevance 0.10
The time course of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) release in patients with acute myocardial infarction (AMI) is unknown.
Localization (release) of HGF in hepatocyte associated with myocardial infarction
19) Confidence 0.45 Published 2000 Journal Cardiology Section Abstract Doc Link 10965088 Disease Relevance 0.63 Pain Relevance 0.12
The time course of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) release in patients with acute myocardial infarction (AMI) is unknown.
Localization (release) of hepatocyte growth factor in hepatocyte associated with myocardial infarction
20) Confidence 0.45 Published 2000 Journal Cardiology Section Abstract Doc Link 10965088 Disease Relevance 0.63 Pain Relevance 0.12

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