INT86813

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 26
Total Number 60
Disease Relevance 42.31
Pain Relevance 10.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) Golgi apparatus (Pla2g4a) endoplasmic reticulum (Pla2g4a)
nucleus (Pla2g4a) cytoplasm (Pla2g4a)
Anatomy Link Frequency
brain 3
lymph node 2
colon 2
nerve 2
neurons 2
Pla2g4a (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 564 99.98 Very High Very High Very High
COX-2 inhibitor 115 99.24 Very High Very High Very High
fibrosis 105 99.02 Very High Very High Very High
antagonist 90 98.72 Very High Very High Very High
cINOD 108 98.62 Very High Very High Very High
Hippocampus 218 98.52 Very High Very High Very High
midbrain 8 98.04 Very High Very High Very High
cerebral cortex 208 97.88 Very High Very High Very High
Thalamus 8 97.64 Very High Very High Very High
Spinal cord 46 96.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1771 100.00 Very High Very High Very High
Ganglion Cysts 570 99.98 Very High Very High Very High
Recurrence 175 99.96 Very High Very High Very High
Familial Adenomatous Polyposis 43 99.96 Very High Very High Very High
Colon Cancer 1320 99.84 Very High Very High Very High
Motor Neuron Diseases 8 99.60 Very High Very High Very High
Adenoma 181 99.36 Very High Very High Very High
Adenocarcinoma 35 99.16 Very High Very High Very High
Disease 106 99.04 Very High Very High Very High
Cystic Fibrosis 105 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is in agreement with previous studies reporting that epithelial cells from CF patients release more AA than control cells and express higher levels of cPLA2?
Gene_expression (express) of cPLA2 in epithelial cells associated with fibrosis
1) Confidence 0.75 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.19 Pain Relevance 0.12
We therefore examined cPLA2 expression in human ALS and mutant Cu/Zn superoxide dismutase (SOD1) transgenic mice and its relation to COX-2.
Gene_expression (expression) of cPLA2 associated with targeted disruption and motor neuron diseases
2) Confidence 0.71 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15816863 Disease Relevance 0.85 Pain Relevance 0.20
In addition to clinicopathologic parameters such as TNM staging, differentiation, and recurrence, we also evaluated VEGF expression, which is known to be up-regulated in most human tumors, including colorectal cancer, and has been associated with increased invasiveness, recurrent disease, and a poor prognosis.26 We then compared VEGF expression (which was used in this study as a tumor progression marker) with those of cPLA2, COX-2, mPGES-1, and 15-PGDH to determine whether these enzymes act as tumor promoters or suppressors.


Gene_expression (expression) of cPLA2 associated with cancer, colon cancer, disease and recurrence
3) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.25 Pain Relevance 0.13
Furthermore, cPLA2 knock-out mice were found to have dramatically reduced small bowel polyp development but not colonic polyp development, suggesting that cPLA2 had an oncologic effect.34,35 On the other hand, cPLA2 expression was diminished in azoxymethane-induced mouse colon tumors,36 and knock-out of cPLA2 enhanced colon tumor development.37 Moreover, available results on cPLA2 expression in human colorectal adenocarcinoma have also been highly variable.
Gene_expression (expression) of cPLA2 in colon associated with adenocarcinoma, targeted disruption, colon cancer, polyps and colonic polyps
4) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.40 Pain Relevance 0
Furthermore VEGF levels were found to be significantly elevated when both cPLA2 and COX-2 were expressed.
Gene_expression (expressed) of cPLA2
5) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.37 Pain Relevance 0
Some have suggested that cPLA2 is overexpressed,38-40 whereas others have concluded to the contrary.36,41,42 However, the study sample sizes were relatively small, i.e., ranging from 5 to 48.
Gene_expression (overexpressed) of cPLA2
6) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.32 Pain Relevance 0
Comparing the correlation of their expression with their staining scores, COX-2 expression was positively correlated with cPLA2 expression (Fig. 2, p = 0.002), but not with 15-PGDH expression (data not shown).


Gene_expression (expression) of cPLA2
7) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.51 Pain Relevance 0
Moreover, cPLA2 is widely expressed and plays an essential role in stimulus-induced AA release.14,15 Because of its importance in the generation of prostaglands (PGs), it has also been suggested to participate in intestinal tumorigenesis.
Gene_expression (expressed) of cPLA2
8) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.58 Pain Relevance 0.03
Panel, et al.27 reported that cPLA2 was overexpressed in 49% of 65 patients with colorectal cancers, and that cPLA2 expression was correlated with COX-2 expression, which concurs with our findings; i.e., we demonstrated that cPLA2 was overexpressed in 54.5% of CRCs (n = 88), and that cPLA2 expression was correlated with the expressions of COX-2 and VEGF.
Gene_expression (overexpressed) of cPLA2 associated with colon cancer
9) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.29 Pain Relevance 0
Panel, et al.27 reported that cPLA2 was overexpressed in 49% of 65 patients with colorectal cancers, and that cPLA2 expression was correlated with COX-2 expression, which concurs with our findings; i.e., we demonstrated that cPLA2 was overexpressed in 54.5% of CRCs (n = 88), and that cPLA2 expression was correlated with the expressions of COX-2 and VEGF.
Gene_expression (expression) of cPLA2 associated with colon cancer
10) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.22 Pain Relevance 0
Studies on the profiles and effects of cPLA2 expression in CRC have also revealed disparate results.
Gene_expression (expression) of cPLA2 associated with colon cancer
11) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.41 Pain Relevance 0
Seventy nine of total 89 cases were evaluated for both COX-2 expression and cPLA2 expression.
Gene_expression (expression) of cPLA2
12) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.55 Pain Relevance 0
Furthermore, cPLA2 knock-out mice were found to have dramatically reduced small bowel polyp development but not colonic polyp development, suggesting that cPLA2 had an oncologic effect.34,35 On the other hand, cPLA2 expression was diminished in azoxymethane-induced mouse colon tumors,36 and knock-out of cPLA2 enhanced colon tumor development.37 Moreover, available results on cPLA2 expression in human colorectal adenocarcinoma have also been highly variable.
Gene_expression (expression) of cPLA2 in colon associated with adenocarcinoma, targeted disruption, colon cancer, polyps and colonic polyps
13) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.50 Pain Relevance 0
These results strongly suggest that cPLA2 plays an important role in tumor development and/or progression in CRC, and that the expressions of cPLA2 plus COX-2 might be a good marker of tumor progression and/or prognosis.
Gene_expression (expressions) of cPLA2 associated with cancer and colon cancer
14) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.30 Pain Relevance 0
cPLA2 expression was positive in 54.4% (48/88) of tumor samples, COX-2 in 80.5% (66/82), mPGES-1 in 96.4% (81/84), and 15-PGDH in 46.1% (41/89). cPLA2 expression was significantly related to VEGF expression (p = 0.016).
Gene_expression (expression) of cPLA2 associated with cancer
15) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.45 Pain Relevance 0
cPLA2 expression was positive in 54.4% (48/88) of tumor samples, COX-2 in 80.5% (66/82), mPGES-1 in 96.4% (81/84), and 15-PGDH in 46.1% (41/89). cPLA2 expression was significantly related to VEGF expression (p = 0.016).
Gene_expression (expression) of cPLA2 associated with cancer
16) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.37 Pain Relevance 0
In two animal models of familial adenomatous polyposis, cPLA2 was overexpressed in small bowel adenoma, but not in colonic adenoma.
Neg (not) Gene_expression (overexpressed) of cPLA2 in bowel associated with adenoma and familial adenomatous polyposis
17) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.48 Pain Relevance 0
Panel, et al.27 reported that cPLA2 was overexpressed in 49% of 65 patients with colorectal cancers, and that cPLA2 expression was correlated with COX-2 expression, which concurs with our findings; i.e., we demonstrated that cPLA2 was overexpressed in 54.5% of CRCs (n = 88), and that cPLA2 expression was correlated with the expressions of COX-2 and VEGF.
Gene_expression (overexpressed) of cPLA2 associated with colon cancer
18) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.25 Pain Relevance 0
In conclusion, the present study demonstrates that cPLA2 and mPGES-1, in addition to COX-2, are constitutively overexpressed, and that 15-PGDH might be attenuated in colorectal carcinoma.
Gene_expression (overexpressed) of cPLA2 associated with colon cancer
19) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.07 Pain Relevance 0
Although cPLA2 expression was not significantly related to clinicopathologic parameters such as TNM staging, lymph node status, grade of differentiation, and recurrence, cPLA2 expression tended to be high in patients with an advanced stage or unfavorable clinicopathologic features such as pT3/pT4, positive lymph node metastasis, elevated pre-operative CEA levels, and positive recurrence.
Gene_expression (expression) of cPLA2 in lymph node associated with metastasis and recurrence
20) Confidence 0.66 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.41 Pain Relevance 0

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