INT86814

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.35
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) Golgi apparatus (Pla2g4a) endoplasmic reticulum (Pla2g4a)
nucleus (Pla2g4a) cytoplasm (Pla2g4a)
Anatomy Link Frequency
spinal cord 1
Pla2g4a (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 99.40 Very High Very High Very High
cINOD 19 99.06 Very High Very High Very High
fibrosis 1 96.28 Very High Very High Very High
Chronic pancreatitis 7 93.48 High High
Inflammation 3 86.12 High High
Inflammatory mediators 1 75.00 Quite High
COX-2 inhibitor 1 62.96 Quite High
aspirin 2 53.20 Quite High
COX2 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Metaplasia 3 99.04 Very High Very High Very High
Targeted Disruption 4 96.28 Very High Very High Very High
Fibrosis 1 96.28 Very High Very High Very High
Motor Neuron Diseases 7 94.04 High High
Pancreatitis 7 93.48 High High
INFLAMMATION 9 86.12 High High
Cancer 4 62.16 Quite High
Colon Cancer 2 55.88 Quite High
Gliosis 1 46.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry and real-time RT-PCR revealed elevated cPLA2 protein and its mRNA levels in the lumbar spinal cord of mutant SOD1 mice.
Transcription (levels) of cPLA2 protein in spinal cord associated with spinal cord
1) Confidence 0.49 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15816863 Disease Relevance 0.91 Pain Relevance 0.27
Most significantly, NSAID treatment appears to drastically suppress the production of cytosolic PLA2 (cPLA2) mRNA.
Transcription (production) of cPLA2 associated with cinod
2) Confidence 0.16 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10706128 Disease Relevance 0.24 Pain Relevance 0.59
Most significantly, NSAID treatment appears to drastically suppress the production of cytosolic PLA2 (cPLA2) mRNA.
Transcription (production) of cytosolic PLA2 associated with cinod
3) Confidence 0.14 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10706128 Disease Relevance 0.24 Pain Relevance 0.59
Increased PLA2-II and PLA2-IV mRNA levels were associated with a higher degree of tissue destruction, ductal metaplasia and degree of fibrosis.
Transcription (levels) of PLA2-IV associated with fibrosis and metaplasia
4) Confidence 0.09 Published 1998 Journal Langenbecks Arch Chir Suppl Kongressbd Section Abstract Doc Link 14518291 Disease Relevance 0.95 Pain Relevance 0.69

General Comments

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