INT86815

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Context Info
Confidence 0.55
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 5.72
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Anatomy Link Frequency
tube 1
colon 1
spinal cord 1
alveolar macrophages 1
gland 1
Pla2g2a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 92 100.00 Very High Very High Very High
Spinal cord 23 99.84 Very High Very High Very High
bradykinin 30 99.40 Very High Very High Very High
Inflammation 147 96.44 Very High Very High Very High
Bile 2 96.04 Very High Very High Very High
cINOD 27 95.56 Very High Very High Very High
Inflammatory response 18 93.64 High High
intrathecal 10 91.44 High High
Dynorphin 1 90.48 High High
agonist 48 90.24 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 177 99.08 Very High Very High Very High
Disease 155 98.08 Very High Very High Very High
Cancer 187 97.40 Very High Very High Very High
Necrosis 27 97.00 Very High Very High Very High
INFLAMMATION 171 96.44 Very High Very High Very High
Pressure And Volume Under Development 42 93.32 High High
Death 20 90.00 High High
Natriuresis 19 89.80 High High
Pain 83 88.48 High High
Chronic Renal Failure 20 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other polymorphic genes exist apart from sPLA2, which may also alter the likelihood of either disease development or expression.
Gene_expression (exist) of sPLA2 associated with disease
1) Confidence 0.55 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 0.61 Pain Relevance 0.19
Interestingly, Mom-1 lies in a region of synteny with the human chromosomal segment 1p35-36, a region that shows frequent somatic loss of heterozygosity in a variety of human tumor types, including colon [56].
Gene_expression (lies) of Mom-1 in colon associated with cancer
2) Confidence 0.55 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 0.85 Pain Relevance 0
Whereas the expression of Cyp2c40 and 2c38 was unaffected by 5/6-Nx, sPLA2-mRNA expression was increased, suggesting a possible enhanced supply of CYP450-enzymes with arachidonic acid (Fig. 6A).
Gene_expression (expression) of sPLA2-mRNA
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.14 Pain Relevance 0.05
In order to determine whether changes in EET production underlie the effects observed, the renal expression of sPLA2, sEH and CYP450 enzymes was determined.
Gene_expression (expression) of sPLA2
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.15 Pain Relevance 0.05
However, we cannot exclude the contribution of another PLA2, iPLA2, to this process.
Gene_expression (contribution) of PLA2
5) Confidence 0.42 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.16 Pain Relevance 0.12
Cultured cells were grown on superfrost slides and stained for phospholypase A2 (PLA2; Abcam, ab58375) and inducible nitric oxide synthase (iNOS; Abcam, ab15323) after 24 hours of treatment with 0.1 ?
Gene_expression (nitric oxide synthase) of PLA2
6) Confidence 0.34 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.18 Pain Relevance 0
EA conceived of the study, coordinated the research, performed and analysed CD34, VEGF, PLA2, and iNOS staining, VEGF ELISA, CFSE and PI staining, and wrote the manuscript.
Spec (analysed) Gene_expression (staining) of PLA2
7) Confidence 0.34 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.59 Pain Relevance 0
Several PLA2 forms are expressed in spinal cord, and inhibiting spinal PLA2 induces a potent antihyperalgesia [63].
Gene_expression (expressed) of PLA2 in spinal cord associated with spinal cord
8) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.35 Pain Relevance 0.52
BK and histamine are coupled to PLA2, activation of which, in turn, can produce AA and its metabolites leading to the modulation of TRPV1 [160].


Gene_expression (produce) of PLA2 associated with bradykinin
9) Confidence 0.23 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.09 Pain Relevance 0.39
Interestingly, at long-term follow-up, the rates of MACE were significantly higher in PlA2 group compared to PlA1 (43.5% vs 25.8%, p 0.018).
Gene_expression (group) of PlA2
10) Confidence 0.17 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954874 Disease Relevance 0.40 Pain Relevance 0.11
PLA2 abundance was similar to B. insularis, greater than B. jararaca but less than B. atrox and B. jararacussu; the latter species was the only one in which PLA2 transcripts were more abundant than metalloproteinases (at least two-fold greater).
Gene_expression (abundant) of PLA2 associated with metalloproteinase
11) Confidence 0.16 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3017861 Disease Relevance 0.07 Pain Relevance 0.18
The venom gland expressed the major toxin groups (metalloproteinases, PLA2, serine proteases, C-type lectins and BPP/CNPs) identified in transcriptomic and proteomic analyses of other Bothrops species.
Gene_expression (expressed) of PLA2 in gland associated with metalloproteinase
12) Confidence 0.14 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3017861 Disease Relevance 0.30 Pain Relevance 0.20
Phospholipases A2 were essentially acidic; no basic PLA2 were detected.
Neg (no) Gene_expression (detected) of PLA2
13) Confidence 0.14 Published 2010 Journal BMC Genomics Section Abstract Doc Link PMC3017861 Disease Relevance 0.09 Pain Relevance 0.14
The current report intended to overcome such problems in that GL, Cdyn and EF50 were measured simultaneously in intact mice including local aerosol challenges via an orotracheal tube.
Gene_expression (measured) of EF50 in tube
14) Confidence 0.11 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.15 Pain Relevance 0
Baseline GL, Cdyn and EF50 values were not significantly different from initial baseline values.
Gene_expression (values) of EF50
15) Confidence 0.11 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.33 Pain Relevance 0
Despite these methodological restrictions, the observed EF50 responses still reflected the enhanced AR to ACh and allergen under the conditions of this study.
Gene_expression (responses) of EF50
16) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.08 Pain Relevance 0
Although all three parameters, Cdyn, GL and EF50, adequately reflected the pronounced EAR in allergic mice there was enhanced variation between GL vs.
Gene_expression (reflected) of EF50 associated with hypersensitivity
17) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.45 Pain Relevance 0
Respiratory parameters were averaged in 5 s segments and minimum GL, Cdyn and EF50 values were taken and expressed as percent changes from corresponding baseline values.
Gene_expression (expressed) of EF50 in Respiratory
18) Confidence 0.09 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0 Pain Relevance 0.09
An argument for the importance of 15d-PGJ2 in alveolar macrophages is that lipopolysaccharide-induced synthesis of secretory type IIA phospholipase A2 is inhibited by arachidonic acid, a precursor of 15d-PGJ2 but not by its nonmetabolizable analog 5,8,11,15-tetraynoic acid [73].
Gene_expression (synthesis) of IIA phospholipase A2 in alveolar macrophages
19) Confidence 0.07 Published 2007 Journal PPAR Research Section Body Doc Link PMC2066181 Disease Relevance 0.13 Pain Relevance 0.04
Group II (lead-treated animals): Lead exposure produced pronounced hepatic histopathological alterations in liver including focal necrosis with inflammatory cells, congestion at places, sinusoids not patent, centrilobular swelling, hepatocyte vacuolation and swelling, parenchyma disorganization, dilation of the inter hepatocyte space, and hemorrhagic clots when compared with group I [Figure 2].
Gene_expression (produced) of Group II in parenchyma associated with pressure and volume under development, necrosis and inflammation
20) Confidence 0.05 Published 2010 Journal Toxicology International Section Body Doc Link PMC2964743 Disease Relevance 0.43 Pain Relevance 0.05

General Comments

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