INT86816

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.27
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) Golgi apparatus (Pla2g4a) endoplasmic reticulum (Pla2g4a)
nucleus (Pla2g4a) cytoplasm (Pla2g4a)
Anatomy Link Frequency
lymph node 2
colon 2
Pla2g4a (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 22 98.86 Very High Very High Very High
aspirin 4 28.68 Quite Low
COX2 2 25.00 Low Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 10 99.96 Very High Very High Very High
Colon Cancer 76 98.76 Very High Very High Very High
Colonic Polyps 2 98.30 Very High Very High Very High
Targeted Disruption 4 97.96 Very High Very High Very High
Polyps 2 97.62 Very High Very High Very High
Metastasis 8 95.40 Very High Very High Very High
Cancer 100 93.92 High High
Adenocarcinoma 2 93.04 High High
Adenoma 10 91.52 High High
Familial Adenomatous Polyposis 2 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, cPLA2 knock-out mice were found to have dramatically reduced small bowel polyp development but not colonic polyp development, suggesting that cPLA2 had an oncologic effect.34,35 On the other hand, cPLA2 expression was diminished in azoxymethane-induced mouse colon tumors,36 and knock-out of cPLA2 enhanced colon tumor development.37 Moreover, available results on cPLA2 expression in human colorectal adenocarcinoma have also been highly variable.
Negative_regulation (diminished) of Gene_expression (expression) of cPLA2 in colon associated with adenocarcinoma, targeted disruption, colon cancer, polyps and colonic polyps
1) Confidence 0.50 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.50 Pain Relevance 0
Although cPLA2 expression was not significantly related to clinicopathologic parameters such as TNM staging, lymph node status, grade of differentiation, and recurrence, cPLA2 expression tended to be high in patients with an advanced stage or unfavorable clinicopathologic features such as pT3/pT4, positive lymph node metastasis, elevated pre-operative CEA levels, and positive recurrence.
Negative_regulation (high) of Gene_expression (expression) of cPLA2 in lymph node associated with metastasis and recurrence
2) Confidence 0.36 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.43 Pain Relevance 0
Our results raise the possibility that deprivation of COX-2 of its substrate by the suppression of cPLA2 mRNA expression is an additional mechanism used by NSAIDs to inhibit tumorigenesis.
Negative_regulation (suppression) of Gene_expression (expression) of cPLA2 mRNA associated with cinod
3) Confidence 0.13 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10706128 Disease Relevance 0.17 Pain Relevance 0.45
Our results suggest that: (a) sPLA2IB receptor-mediated COX-2 expression is mediated via C/EBPbeta; (b) NSAIDs in the presence of sPLA2IB potentiate the stimulatory effects of sPLA2IB on COX-2 mRNA expression; and (c) despite the apparent stimulation of COX-2 expression by NSAIDs, they strikingly deprive COX-2 of its substrate, AA, by suppressing cPLA2 mRNA expression.
Negative_regulation (suppressing) of Gene_expression (expression) of cPLA2 mRNA associated with cinod
4) Confidence 0.13 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10706128 Disease Relevance 0.17 Pain Relevance 0.48

General Comments

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