INT8683

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2011
Negated 0
Speculated 21
Reported most in Body
Documents 31
Total Number 52
Disease Relevance 42.89
Pain Relevance 6.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) extracellular region (F3)
plasma membrane (F3) cytoplasm (F3)
Anatomy Link Frequency
platelet 8
blood 5
plasma 3
endothelial cells 3
macrophages 1
F3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 94 99.98 Very High Very High Very High
Inflammation 195 99.78 Very High Very High Very High
Bioavailability 9 99.08 Very High Very High Very High
epidural 25 98.96 Very High Very High Very High
imagery 37 97.02 Very High Very High Very High
bradykinin 22 94.32 High High
anesthesia 48 93.72 High High
corticosteroid 40 93.52 High High
headache 49 93.28 High High
abdominal pain 10 92.80 High High
Disease Link Frequency Relevance Heat
Infarction 9 100.00 Very High Very High Very High
Hepatotoxicity 16 99.92 Very High Very High Very High
Acute Coronary Syndrome 44 99.84 Very High Very High Very High
INFLAMMATION 187 99.78 Very High Very High Very High
Stroke 90 99.58 Very High Very High Very High
Hyperglycemia 52 99.54 Very High Very High Very High
Systemic Lupus Erythematosus 92 99.52 Very High Very High Very High
Injury 316 99.44 Very High Very High Very High
Coagulation Disorder 182 99.42 Very High Very High Very High
Thrombocytopenia 64 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, activated protein C (APC), and activity for von Willebrand factor (vWF) (n = 14–16 in each group) using a commercial kit (Diagnostica Stago, Roche, Tokyo, Japan) and an STA Compact analyzer (Diagnostica Stago, Roche) as previously described (Inoue et al. 2004).


Positive_regulation (activated) of thromboplastin
1) Confidence 0.67 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570092 Disease Relevance 0.30 Pain Relevance 0.12
Most were also investigated with electrocardiograms, ultrasound of the precerebral vessels and cerebral magnetic resonance imaging (MRI), as well as extensive blood chemistry screening for coagulation parameters, hemoglobin (Hb), platelet count, erythrocyte sedimentation rate (ESR), activated partial thromboplastin time (APPT), fibrinogen, protein S and C, lupus anticoagulant and anticardiolipin antibodies, homocystein and antithrombin 3.
Spec (partial) Positive_regulation (activated) of thromboplastin in blood associated with systemic lupus erythematosus and imagery
2) Confidence 0.67 Published 2007 Journal BMC Med Section Body Doc Link PMC1939710 Disease Relevance 0.29 Pain Relevance 0.41
We cooled 16 anesthetized patients scheduled for elective intracranial surgery to 32 degrees C body core temperature and assessed prothrombin time (PT), activated partial thromboplastin time, thrombelastogram (TEG), closure time, and platelet count at 36 degrees C, 34 degrees C, and 32 degrees C body core temperature after the induction of anesthesia but before surgical intervention.
Positive_regulation (activated) of thromboplastin in body associated with anesthesia
3) Confidence 0.50 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12761010 Disease Relevance 0.24 Pain Relevance 0.09
In addition to the routine laboratory investigations, the level of serum cholesterol and triglyceride were measured, and an hemostasis screening test (prothrombin time, thrombin time, activated partial thromboplastin time) was performed.
Positive_regulation (activated) of thromboplastin
4) Confidence 0.49 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2694013 Disease Relevance 0.78 Pain Relevance 0
From each sample, hemoglobin (Hb) level and coagulation parameters including, platelet count, prothrombin time (PT), and activated partial thromboplastin time (aPTT) were measured immediately after collection.
Spec (partial) Positive_regulation (activated) of thromboplastin in platelet
5) Confidence 0.49 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.56 Pain Relevance 0.19
The participants were tested for haemoglobin level, platelet count, serum creatinin and activated partial thromboplastin (APT) time.
Spec (partial) Positive_regulation (activated) of thromboplastin in platelet
6) Confidence 0.49 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2955688 Disease Relevance 0.95 Pain Relevance 0.07
CONCLUSIONS: This study calls into question whether LLD plays a significant role in persistence of LBP in TFA.
Spec (whether) Positive_regulation (persistence) of TFA
7) Confidence 0.49 Published 2009 Journal Am J Phys Med Rehabil Section Body Doc Link 19169176 Disease Relevance 0.07 Pain Relevance 0
1.3 mg/dl), coagulation [prothrombin time international normalized ratio (PT-INR) <1.3, activated partial thromboplastin time (APTT) <60 s], pulmonary [arterial oxygen pressure (PaO2) ?
Spec (partial) Positive_regulation (activated) of thromboplastin
8) Confidence 0.49 Published 2009 Journal Japanese Journal of Clinical Oncology Section Body Doc Link PMC2661001 Disease Relevance 0.83 Pain Relevance 0
22/24).Vascular malformation, by means of cerebral CT, MRI or angio-MRI if necessary.Hypercoagulable states, hematological disorders, and inflammatory diseases, with biological tests carried out at least 2 months after stroke: prothrombin ratio, activated partial thromboplastin time, C and S proteins, antithrombin, mutation in Factor V Leiden gene, circulating anticoagulants, antiphospholipid and anti-ß2gp1 antibodies, homocysteinemia, erythrocyte sedimentation rate, and C-reactive protein.
Spec (partial) Positive_regulation (activated) of thromboplastin in erythrocyte associated with hematological disease, vascular malformations, inflammation, stroke and disease
9) Confidence 0.49 Published 2010 Journal J Interv Card Electrophysiol Section Body Doc Link PMC2921065 Disease Relevance 1.24 Pain Relevance 0.16
(INR) >1.2 and activated partial thromboplastin time (APTT) were brought to normal values before the insertion of epidural catheter.
Positive_regulation (activated) of thromboplastin associated with epidural
10) Confidence 0.49 Published 2010 Journal Indian Journal of Anaesthesia Section Body Doc Link PMC3016572 Disease Relevance 0.06 Pain Relevance 0.45
120 Hematology Analyzer, ABX Diagnostics, Irvine, CA); 3) total plasma protein, glucose, creatinine, lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), amylase and lactate (Vitros Chemistry System, Ortho Clinical Diagnostics, Raritan, NJ); and 4) baseline prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen and platelet concentration (ACL Futura Automatic Coagulation Analyzer, Instrumentation Laboratories, Lexington, MA).
Positive_regulation (activated) of thromboplastin in plasma
11) Confidence 0.49 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999718 Disease Relevance 0.08 Pain Relevance 0.10
The following data were collected from the Institutional Database or direct analysis of the perfusion files: demographics: age (months), weight (kg), gender; type of surgical operation with Aristotle complexity score [16]; preoperative laboratory data: hematocrit (percentage), platelet count (cells/microliter), prothrombin time (seconds), activated partial thromboplastin time (seconds), antithrombin (percentage), serum creatinine value (milligrams per deciliter); CPB data: CPB duration (minutes), lowest temperature on CPB (degrees Centigrade), use of blood prime, ScVO2 values (percentage), and lactate values (mmol/L).
Spec (partial) Positive_regulation (activated) of thromboplastin in blood
12) Confidence 0.49 Published 2010 Journal Crit Care Section Body Doc Link PMC2945132 Disease Relevance 0 Pain Relevance 0
Laboratory features of human H5N1 infection include leucopoenia, especially lymphopenia, elevated amino-transaminases, thrombocytopenia, prolonged prothrombin time and activated partial thromboplastin time, increased D-Dimer, increased serum lactate dehydrogenase and creatinine phospho-kinase, and hypoalbuminemia.
Spec (partial) Positive_regulation (activated) of thromboplastin associated with lymphopenia, thrombocytopenia, hypoalbuminemia and infection
13) Confidence 0.48 Published 2008 Journal Respirology Section Abstract Doc Link 18366521 Disease Relevance 2.17 Pain Relevance 0.09
We used the following definitions: cardiac failure was defined as requiring use of inotropic agents; respiratory failure was defined as the need for assisted ventilatiory support; ARDS was defined as clinical deterioration with severe arterial hypoxaemia and diffuse bilateral infiltrates on chest radiograph; disseminated intravenous coagulation (DIC) was defined as elevated prothrombin time (PT) with elevated activated partial thromboplastin time (APTT), and decreased fibrinogen (FIB) level with thrombocytopenia; liver function impairment was defined as aminotransferase (ALT or AST) levels ?
Spec (partial) Positive_regulation (elevated) of thromboplastin in chest associated with respiratory failure, thrombocytopenia, disseminated intravascular coagulation, adult respiratory distress syndrome and myocardial infarction
14) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.56 Pain Relevance 0.07
Immediately before injection and at various times thereafter (after 15 min and 30 min for i.v. only and after 1, 2, 3, 4, 6, 8, 12, and 24 h for both s.c. and i.v. dosing), blood samples were drawn to investigate bioavailability by measuring several coagulation parameters: activated partial thromboplastin time, thrombin time, inhibition of factor Xa, Heptest, and heparin cofactor II.
Spec (partial) Positive_regulation (activated) of thromboplastin in blood associated with bioavailability
15) Confidence 0.42 Published 1997 Journal Int. J. Clin. Lab. Res. Section Abstract Doc Link 9352383 Disease Relevance 0 Pain Relevance 0.20
The partial thromboplastin time and international normalized ratio were significantly increased in the HES 264/0.45 group compared with the albumin group after infusion of 30 mL/kg and 45 mL/kg (P < 0.05).
Positive_regulation (increased) of thromboplastin
16) Confidence 0.38 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15920225 Disease Relevance 0 Pain Relevance 0.09
His activated partial thromboplastin time (aPTT) gradually improved (38.4 seconds).
Positive_regulation (activated) of thromboplastin
17) Confidence 0.34 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918632 Disease Relevance 0.72 Pain Relevance 0
Coagulation studies revealed a prolonged activated partial thromboplastin time and a mixing study was consistent with the presence of an inhibitor.
Spec (partial) Positive_regulation (activated) of thromboplastin
18) Confidence 0.34 Published 2010 Journal J Med Case Reports Section Abstract Doc Link PMC2918632 Disease Relevance 0.97 Pain Relevance 0.04
Despite the continuously prolonged activated partial thromboplastin time and low FVIII levels, the patient maintained a remarkably dry surgical field.
Positive_regulation (activated) of thromboplastin
19) Confidence 0.30 Published 2003 Journal Haemophilia Section Abstract Doc Link 12558792 Disease Relevance 0.73 Pain Relevance 0.07
Routine coagulation tests, such as the prothrombin time and the activated partial thromboplastin time, do not reflect this state, as they are sensitive for coagulation defects not for hypercoagulability [2].
Positive_regulation (activated) of thromboplastin associated with coagulation disorder and thrombophilia
20) Confidence 0.29 Published 2006 Journal Crit Care Section Body Doc Link PMC1794466 Disease Relevance 0.77 Pain Relevance 0.08

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