INT86834

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.90
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tg) extracellular region (Tg) Golgi apparatus (Tg)
endoplasmic reticulum (Tg)
Anatomy Link Frequency
lateral 2
erythrocyte 1
muscles 1
brain 1
Tg (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 52 99.78 Very High Very High Very High
Inflammatory response 1 98.68 Very High Very High Very High
Pain 12 96.44 Very High Very High Very High
Inflammation 24 88.88 High High
antagonist 24 87.12 High High
imagery 91 82.92 Quite High
Lamotrigine 2 60.12 Quite High
sodium channel 4 59.44 Quite High
Transcranial magnetic stimulation 52 50.00 Quite Low
cINOD 4 45.48 Quite Low
Disease Link Frequency Relevance Heat
Recurrence 11 98.92 Very High Very High Very High
INFLAMMATION 30 98.32 Very High Very High Very High
Desmoid Disease 2 97.88 Very High Very High Very High
Disease 134 96.80 Very High Very High Very High
Thyroid Neoplasm 53 96.16 Very High Very High Very High
Targeted Disruption 28 94.68 High High
Cancer 216 94.52 High High
Thyroiditis 9 93.28 High High
Autoimmune Thyroiditis 1 93.12 High High
Dysphagia 2 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Physical examination, elevated erythrocyte sedimentation rate, elevated thyroglobulin level and depressed radioactive iodine uptake (RAIU) confirm the diagnosis.
Positive_regulation (elevated) of thyroglobulin in erythrocyte
1) Confidence 0.69 Published 2000 Journal Am Fam Physician Section Abstract Doc Link 10706157 Disease Relevance 1.25 Pain Relevance 0.14
Immunohistochemistry was positive for vimentin and negative for thyroglobulin.
Positive_regulation (negative) of thyroglobulin
2) Confidence 0.32 Published 2006 Journal J. Endocrinol. Invest. Section Abstract Doc Link 16553038 Disease Relevance 0.79 Pain Relevance 0.18
This high stability in COG has been observed in serial studies of patients with unilateral motor problems, in which the less affected side was stable to within 2–3 mm over periods from weeks to years [24].
Positive_regulation (stability) of COG
3) Confidence 0.12 Published 2005 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1175099 Disease Relevance 0.22 Pain Relevance 0
However substantial variability in MEPs over trials may also increase COG movement.


Spec (may) Positive_regulation (increase) of COG
4) Confidence 0.12 Published 2005 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1175099 Disease Relevance 0.14 Pain Relevance 0
The calculation of COG is dependent on MEP characteristics which differ for distal and more proximal muscles.
Positive_regulation (calculation) of COG in muscles
5) Confidence 0.10 Published 2005 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1175099 Disease Relevance 0 Pain Relevance 0
can be generated in several subcellular compartments within the cell, such as the ER, Golgi/TGN, and endosome/lysosome.
Positive_regulation (generated) of TGN
6) Confidence 0.10 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.78 Pain Relevance 0
Therefore a reproducibly large change in MEP amplitude is necessary for significant movement in COG over sessions.
Positive_regulation (necessary) of COG
7) Confidence 0.09 Published 2005 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1175099 Disease Relevance 0.13 Pain Relevance 0
Each such patient had an elevated thyroglobulin level, a negative 131I scan, demonstration of recurrent locoregional recurrent disease on a preoperative 99mTc-MIBI scan and on a high-resolution ultrasound, and no demonstration of distant metastatic disease [461,462].
Positive_regulation (elevated) of thyroglobulin associated with disease and metastasis
8) Confidence 0.05 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2653072 Disease Relevance 0.79 Pain Relevance 0.04
Thus it is not conceivable that memantine, which is also known to affect motor cortex excitability [32], induces a (lateral) directional shift of the COG on its own, and therefore only masks the training induced medial shift of the COG.
Positive_regulation (induces) of COG in lateral
9) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1134663 Disease Relevance 0 Pain Relevance 0.10
Thus it is not conceivable that memantine, which is also known to affect motor cortex excitability [32], induces a (lateral) directional shift of the COG on its own, and therefore only masks the training induced medial shift of the COG.
Positive_regulation (induces) of COG in lateral
10) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1134663 Disease Relevance 0 Pain Relevance 0.10
All of the cytokines that were increased in the TgAPPsw brain slices (IL-1?
Positive_regulation (increased) of TgAPPsw in brain associated with cytokine
11) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC555557 Disease Relevance 0.81 Pain Relevance 0.47

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