INT8684

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1982
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 45
Total Number 49
Disease Relevance 36.29
Pain Relevance 7.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ANGPTL5) extracellular space (ANGPTL5) extracellular region (ANGPTL5)
Anatomy Link Frequency
platelet 8
plasma 7
erythrocyte 2
heart 2
neutrophil 2
ANGPTL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 485 99.92 Very High Very High Very High
shoulder pain 4 99.90 Very High Very High Very High
rheumatoid arthritis 41 99.84 Very High Very High Very High
cocaine 140 99.72 Very High Very High Very High
Angina 33 99.48 Very High Very High Very High
Inflammatory marker 23 98.78 Very High Very High Very High
cytokine 129 98.66 Very High Very High Very High
Inflammatory response 46 98.34 Very High Very High Very High
metalloproteinase 71 98.26 Very High Very High Very High
bradykinin 10 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hemorrhage 324 100.00 Very High Very High Very High
Alzheimer's Dementia 7 100.00 Very High Very High Very High
Nicotine Addiction 93 99.98 Very High Very High Very High
INFLAMMATION 558 99.92 Very High Very High Very High
Postoperative Hemorrhage 3 99.92 Very High Very High Very High
Shoulder Pain 4 99.90 Very High Very High Very High
Hypoalbuminemia 1 99.88 Very High Very High Very High
Rheumatoid Arthritis 42 99.84 Very High Very High Very High
Thrombophilia 112 99.56 Very High Very High Very High
Thrombosis Related Under Development 10 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sickle erythrocytes adhere more avidly to injured endothelium, under hyperosmolar conditions, and in the presence of increased fibrinogen concentrations.
Positive_regulation (increased) of fibrinogen in endothelium
1) Confidence 0.69 Published 1982 Journal Am J Pediatr Hematol Oncol Section Abstract Doc Link 7149170 Disease Relevance 0.17 Pain Relevance 0.08
The surgery, performed to ligate the artery, induced an increase in the plasma fibrinogen concentration and whole blood viscosity.
Positive_regulation (increase) of fibrinogen in plasma
2) Confidence 0.64 Published 1988 Journal Int J Microcirc Clin Exp Section Abstract Doc Link 3350622 Disease Relevance 0.25 Pain Relevance 0
However, plasma TIA became positive again one month later, in association with reappearance of shoulder pain and elevation of FDP and fibrinogen levels, which were considered due to recurrence of the tumor, 30 Gy of Liniack together with thermotherapy was again given.
Positive_regulation (elevation) of fibrinogen in shoulder associated with cancer, shoulder pain and recurrence
3) Confidence 0.61 Published 1992 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 1447849 Disease Relevance 0.78 Pain Relevance 0.27
Ancrod, snake venom from the Malayan pit viper, was used to lower plasma fibrinogen levels, which allowed successful cardiac catheterization and coronary artery bypass grafting.
Positive_regulation (used) of fibrinogen in plasma
4) Confidence 0.47 Published 1996 Journal Heart Lung Section Abstract Doc Link 8950124 Disease Relevance 0.92 Pain Relevance 0.18
Compared to men without stenosis at baseline, men with stenosis were older, earned less money, had higher levels of LDL cholesterol and fibrinogen, had lower levels of cardiorespiratory fitness, and were more likely to take lipid-lowering or antihypertensive medication (Table 1).
Positive_regulation (levels) of fibrinogen associated with pathologic constriction
5) Confidence 0.40 Published 2009 Journal Prev Chronic Dis Section Body Doc Link PMC2644586 Disease Relevance 1.05 Pain Relevance 0.15
The percentages of neutrophils, fibrinogen, albumin, PGE2, PGF2 alpha, and kinins were elevated in BALF after O3 compared with FA.
Positive_regulation (elevated) of fibrinogen in neutrophils
6) Confidence 0.21 Published 1995 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7551367 Disease Relevance 0.16 Pain Relevance 0.14
Marked elevation of fibrinogen, thrombin-antithrombin III complex (TAT), plasmin-alpha(2) plasmin inhibitor complex (PIC), fibrin degradation products (FDP), and D-Dimer indicated the activation of both coagulation and fibrinolysis in the false lumen.
Positive_regulation (elevation) of fibrinogen in lumen
7) Confidence 0.16 Published 1996 Journal Kyobu Geka Section Abstract Doc Link 8913071 Disease Relevance 0.34 Pain Relevance 0.08
Laboratory results revealed elevated: ESR, acute phase parameters (C-reactive protein, D-dimer), CPK and fibrinogen.
Positive_regulation (elevated) of fibrinogen
8) Confidence 0.14 Published 2010 Journal Adv Med Sci Section Abstract Doc Link 20371436 Disease Relevance 1.47 Pain Relevance 0.23
Changes in coagulation indices were identical in neurosurgical and hysterectomy patients, except for a larger increase in fibrinogen concentration 24 and 48 h after hysterectomy.
Neg (except) Positive_regulation (increase) of fibrinogen
9) Confidence 0.14 Published 1992 Journal Anesth. Analg. Section Abstract Doc Link 1377457 Disease Relevance 0.56 Pain Relevance 0.09
We therefore assume that we excluded patients with the strongest platelet activation, whereas the fibrinogen levels were generally increased at inclusion (Table 1).
Positive_regulation (increased) of fibrinogen in platelet
10) Confidence 0.13 Published 2006 Journal Crit Care Section Body Doc Link PMC1794466 Disease Relevance 0.38 Pain Relevance 0.05
Fibrinogen levels were measured using the same techniques in both studies, so effect estimates for fibrinogen are presented as the linear increase in fibrinogen (grams per liter) per each pollutant’s IQR.
Positive_regulation (increase) of fibrinogen
11) Confidence 0.12 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.36 Pain Relevance 0.09
We recommend that routine practice to detect post-traumatic coagulopathy include the measurement of international normalised ratio (INR), activated partial thromboplastin time (APTT), fibrinogen and platelets.
Spec (partial) Positive_regulation (activated) of fibrinogen in platelets associated with coagulation disorder
12) Confidence 0.10 Published 2010 Journal Crit Care Section Body Doc Link PMC2887168 Disease Relevance 0.62 Pain Relevance 0
Fibrinogen administration using thrombelastometry as guidance may be preferable to measuring fibrinogen levels in the laboratory.
Positive_regulation (measuring) of fibrinogen
13) Confidence 0.10 Published 2010 Journal Crit Care Section Body Doc Link PMC2887168 Disease Relevance 0.41 Pain Relevance 0.03
Atropine significantly reduced the volume of returned lavage fluids and their lysozyme content but increased their albumin and fibrinogen content.
Positive_regulation (increased) of fibrinogen
14) Confidence 0.09 Published 1998 Journal J. Appl. Physiol. Section Abstract Doc Link 9475863 Disease Relevance 0.34 Pain Relevance 0.76
The hypercoagulability was mainly caused by increased plasma fibrinogen, and to a lesser extent by platelets.
Positive_regulation (increased) of fibrinogen in platelets associated with thrombophilia
15) Confidence 0.09 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1794466 Disease Relevance 0.93 Pain Relevance 0
Alternatively, the rapid consumption of fibrinogen may be attributable to the chosen pattern of injury since femur fracture and femur fracture manipulation have been associated with rapid consumption of fibrinogen in both animal models and human studies [41,42].


Positive_regulation (consumption) of fibrinogen in femur associated with injury
16) Confidence 0.09 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC3006355 Disease Relevance 0.95 Pain Relevance 0
The START-4 coagulation analyzer (Diagnostica Stago, Asnières, France) was used to measure prothrombin time (PT) activated partial thromboplastin time (aPTT), and fibrinogen in platelet-poor plasma after centrifugation.
Spec (partial) Positive_regulation (activated) of fibrinogen in platelet
17) Confidence 0.09 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC3006355 Disease Relevance 0.25 Pain Relevance 0
Whereas cLUK significantly decreased plasma levels of alpha 2-antiplasmin, plasminogen and fibrinogen, cPUK caused only a marginal decrease in alpha 2-antiplasmin and left the plasminogen and fibrinogen levels unchanged.
Neg (unchanged) Positive_regulation (unchanged) of fibrinogen in plasma
18) Confidence 0.09 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0
Serum fibrinogen concentrations were significantly increased only in the CSAP group as compared to controls (4.15 +/-1.39 vs 3.45 +/-1.19 g/L, p=0.025).
Positive_regulation (increased) of fibrinogen associated with angina
19) Confidence 0.08 Published 2006 Journal Angiology Section Abstract Doc Link 16703186 Disease Relevance 1.17 Pain Relevance 0.64
Increased fibrinogen and fibrin deposition within joints are prominent indicators of active SJIA flare [46] and arthritis [47].
Positive_regulation (Increased) of fibrinogen in joints associated with arthritis
20) Confidence 0.07 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.85 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox