INT86851

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 45
Total Number 48
Disease Relevance 24.42
Pain Relevance 9.21

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signal transduction (Faslg) extracellular space (Faslg) extracellular region (Faslg)
cytoplasmic membrane-bounded vesicle (Faslg) plasma membrane (Faslg)
Anatomy Link Frequency
liver 5
pancreas 5
acinar cell 4
T cells 3
macrophages 2
Faslg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 144 99.92 Very High Very High Very High
Chronic pancreatitis 49 99.84 Very High Very High Very High
Morphine 32 99.82 Very High Very High Very High
Neuritis 7 98.88 Very High Very High Very High
cytokine 27 98.52 Very High Very High Very High
Sciatic nerve 7 98.28 Very High Very High Very High
Inflammation 54 97.56 Very High Very High Very High
ischemia 99 90.60 High High
Etanercept 52 88.28 High High
Angina 1 86.84 High High
Disease Link Frequency Relevance Heat
Injury 43 100.00 Very High Very High Very High
Cancer 18 99.88 Very High Very High Very High
Pancreatitis 49 99.84 Very High Very High Very High
Malignant Neoplastic Disease 7 99.84 Very High Very High Very High
Necrosis 18 99.52 Very High Very High Very High
Death 71 99.46 Very High Very High Very High
Apoptosis 351 99.18 Very High Very High Very High
Primary Sclerosing Cholangitis 16 98.96 Very High Very High Very High
Disease 7 98.92 Very High Very High Very High
Experimental Autoimmune Neuritis 7 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of FasL expression in KC or macrophages has been achieved in a number of experiments.
Gene_expression (expression) of FasL in macrophages
1) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.22 Pain Relevance 0.17
Replacement of donor KC by recipient-derived KC following OLT may also influence the FasL expression of KC in liver allografts.
Gene_expression (expression) of FasL in liver
2) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.20 Pain Relevance 0.15
On post transplantation days 3, 7 and 12, FasL mRNA expression of KC recovered from the acceptance model was significantly higher than that measured from KC recovered from rejecting allografts (Fig. 1).
Gene_expression (expression) of FasL mRNA
3) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0 Pain Relevance 0
KC express FasL.
Gene_expression (express) of FasL
4) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0 Pain Relevance 0
Donor Lewis hepatic KC replacement by recipient DA KC following liver transplantation results in increased FasL expression by KC in the liver allografts.
Gene_expression (expression) of FasL in liver
5) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.20 Pain Relevance 0.16
KC FasL expression is increased following liver transplantation and associated with increased ability of KC lyses ATC.
Gene_expression (expression) of FasL in liver
6) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.23 Pain Relevance 0.07
IFN-gamma induced overexpression of FasL in KC has been proposed as a mechanism of hepatic immunoregulation [17].
Gene_expression (overexpression) of FasL
7) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.21 Pain Relevance 0.16
Whether a genetic difference in KC FasL expression contributes to allograft acceptance in this model remains to be elucidated.
Gene_expression (expression) of FasL
8) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.20 Pain Relevance 0.15
Cytotoxicity of KC against ATC dependent on FasL expression.
Gene_expression (expression) of FasL
9) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0 Pain Relevance 0
To assess FasL mRNA expression, total RNA was subjected to RT-PCR using the following primers: 5'-ATGCAGCAGCCCATG-3' and 5'-AAGCTTATACAAGCCGAA-3'.
Gene_expression (expression) of FasL mRNA
10) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0 Pain Relevance 0
For example, FasL expression is higher in DA rat KC than in Lewis rat KC.
Gene_expression (expression) of FasL
11) Confidence 0.75 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.20 Pain Relevance 0.15
The aim of this study was to examine the expression of the Fas/FasL system and to analyze its correlation with apoptosis in a spontaneous chronic pancreatitis model (the WBN/Kob rat).
Spec (examine) Gene_expression (expression) of FasL associated with apoptosis and chronic pancreatitis
12) Confidence 0.74 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.71 Pain Relevance 0.24
However, whether Fas and FasL are expressed in chronic pancreatitis is unknown.
Gene_expression (expressed) of FasL associated with chronic pancreatitis
13) Confidence 0.74 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.64 Pain Relevance 0.23
These results suggest that the expression of the Fas/FasL system is involved in acinar cell apoptosis and the onset and progression of chronic pancreatitis in the WBN/Kob rat.
Gene_expression (expression) of FasL in acinar cell associated with apoptosis and chronic pancreatitis
14) Confidence 0.74 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.79 Pain Relevance 0.24
ISH and IHC confirmed that Fas and FasL are expressed in the cytoplasm of acinar cells, ductal cells, and lymphocytes.
Gene_expression (expressed) of FasL in lymphocytes
15) Confidence 0.74 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.65 Pain Relevance 0.24
Regulation of Fas and FasL expression on rat Schwann cells.
Gene_expression (expression) of FasL in Schwann cells
16) Confidence 0.72 Published 2000 Journal Glia Section Title Doc Link 10797617 Disease Relevance 0.59 Pain Relevance 0.12
To assess the possible involvement of the Fas/FasL system in T-cell apoptosis in the PNS of the rat, we characterized Fas and FasL expression on neonatal rat Schwann cells (SC) in vitro.
Gene_expression (expression) of FasL in Schwann cells associated with apoptosis
17) Confidence 0.72 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.64 Pain Relevance 0.12
These findings are in accord with recently published results showing Fas and FasL expression on malignant human cells, derived from brain tumors and upregulation of FasL on astrocytes after exposure to IFN-gamma and TNF-alpha.
Gene_expression (expression) of FasL in astrocytes associated with malignant neoplastic disease and brain tumor
18) Confidence 0.72 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.73 Pain Relevance 0.22
We observed upregulation of FasL expression under the influence of IFN-gamma, while adding TNF-alpha alone to the culture medium had no effect.
Gene_expression (expression) of FasL
19) Confidence 0.72 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.71 Pain Relevance 0.12
We suggest that Fas/FasL expression on SC may contribute to the elimination of invading autoreactive T cells in the PNS in concert with other immune defense mechanisms.
Gene_expression (expression) of FasL in T cells
20) Confidence 0.72 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.46 Pain Relevance 0.18

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