INT86867

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Context Info
Confidence 0.46
First Reported 2000
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 15
Total Number 21
Disease Relevance 4.95
Pain Relevance 7.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
neuronal 3
nerve 2
chondrocytes 1
brain 1
dorsal root ganglia 1
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 11 100.00 Very High Very High Very High
antidepressant 27 99.98 Very High Very High Very High
Opioid 15 99.98 Very High Very High Very High
Kinase C 3 99.74 Very High Very High Very High
Morphine 13 99.32 Very High Very High Very High
alcohol 257 98.92 Very High Very High Very High
Pain 6 98.68 Very High Very High Very High
Serotonin 7 98.60 Very High Very High Very High
Inflammation 8 98.48 Very High Very High Very High
Dopamine 16 98.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sarcoma 24 100.00 Very High Very High Very High
Pain 6 98.68 Very High Very High Very High
INFLAMMATION 8 98.48 Very High Very High Very High
Neuropathic Pain 12 98.28 Very High Very High Very High
Drug Dependence 21 98.00 Very High Very High Very High
Nervous System Injury 10 96.08 Very High Very High Very High
Cystitis 9 95.16 Very High Very High Very High
Alcohol Addiction 4 93.96 High High
Drug Induced Neurotoxicity 81 90.48 High High
Stress 15 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantification of immunoblots optical densities (Odyssey Application Software, 2.0) confirmed that vinpocetine treatment significantly increased CREB phosphorylation in Ethanol treated animals without affecting total CREB levels (Figure 4b).
Neg (without) Regulation (affecting) of CREB
1) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0
The present study examined the roles of cyclic AMP response element-binding protein and of the phosphorylated cyclic AMP response element-binding protein in the maintenance of mechanical and cold allodynia induced by a neuropathic pain model, "spared nerve injury," in rats.
Spec (examined) Regulation (roles) of cyclic AMP response element-binding protein in nerve associated with nervous system injury, allodynia and neuropathic pain
2) Confidence 0.45 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.87 Pain Relevance 0.67
The present study examined the roles of cyclic AMP response element-binding protein and of the phosphorylated cyclic AMP response element-binding protein in the maintenance of mechanical and cold allodynia induced by a neuropathic pain model, "spared nerve injury," in rats.
Spec (examined) Regulation (roles) of cyclic AMP response element-binding protein in nerve associated with nervous system injury, allodynia and neuropathic pain
3) Confidence 0.45 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515839 Disease Relevance 0.85 Pain Relevance 0.66
Importantly, total CREB levels were neither affected by ethanol nor by vinpocetine.
Neg (nor) Regulation (affected) of CREB
4) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0.03
CREB1 is the only other gene in this region previously identified in sarcoma translocations, and a break-apart CREB1 probe was created and applied to the cultured specimen.
Regulation (applied) of CREB1 associated with sarcoma
5) Confidence 0.33 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 0.23 Pain Relevance 0
CREB1 is the only other gene in this region previously identified in sarcoma translocations, and a break-apart CREB1 probe was created and applied to the cultured specimen.
Regulation (created) of CREB1 associated with sarcoma
6) Confidence 0.33 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 0.23 Pain Relevance 0
Further, our results indicate that morphine-induced effects are mediated via the modulation of MAPK and CREB signaling pathways.
Regulation (modulation) of CREB associated with morphine
7) Confidence 0.31 Published 2005 Journal Clin. Immunol. Section Abstract Doc Link 15893700 Disease Relevance 0 Pain Relevance 0.87
CREB1 is the only other gene in this region previously identified in sarcoma translocations, and a break-apart CREB1 probe was created and applied to the cultured specimen.
Regulation (applied) of CREB1 associated with sarcoma
8) Confidence 0.29 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 0.22 Pain Relevance 0
CREB1 is the only other gene in this region previously identified in sarcoma translocations, and a break-apart CREB1 probe was created and applied to the cultured specimen.
Regulation (created) of CREB1 associated with sarcoma
9) Confidence 0.29 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 0.22 Pain Relevance 0
The obtained results indicate that in human articular chondrocytes opioids affect, via the mu-opioid receptor, the transcription factor CREB which in turn can cause subsequent changes in gene expression.
Regulation (affect) of CREB in chondrocytes associated with opioid receptor and opioid
10) Confidence 0.27 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 14575714 Disease Relevance 0.31 Pain Relevance 0.60
Regulation of adenylyl cyclase, ERK1/2, and CREB by Gz following acute and chronic activation of the delta-opioid receptor.
Regulation (Regulation) of CREB associated with opioid receptor
11) Confidence 0.23 Published 2000 Journal J. Neurochem. Section Title Doc Link 10737627 Disease Relevance 0.19 Pain Relevance 0.62
Specifically, we studied a blood–brain barrier drug transporter pump (ACCB1, also called MDR1), which regulates drug entry into the brain (level 1), the norepinephrine, dopamine, and serotonin transporters (SCL6A2, SLC6A3 and SL6A4) (level 2), an antidepressant-regulated transcription factor (cyclic AMP-responsive element binding protein 1 (CREB1)) (level 3) and two receptors (level 4): neurotrophic tyrosine kinase type 2 receptor (NTRK2), important in synaptic function and neural plasticity, and corticotropin-releasing hormone receptor 1 (CRHR1), which regulates the response to stress at the behavioral, neuroimmune and neuroendocrine—hypothalamic–pituitary–adrenalaxis levels.


Regulation (regulated) of cyclic AMP-responsive element binding protein 1 in brain associated with stress, antidepressant, dopamine and serotonin
12) Confidence 0.22 Published 2009 Journal Mol Psychiatry Section Body Doc Link PMC2834349 Disease Relevance 0.41 Pain Relevance 0.24
The cAMP response element-binding protein (CREB) is regulated by phosphorylation in response to neuronal activity patterns [32] and its role in neuronal plasticity has been long established.
Regulation (regulated) of CREB in neuronal
13) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0.19
The cAMP response element-binding protein (CREB) is regulated by phosphorylation in response to neuronal activity patterns [32] and its role in neuronal plasticity has been long established.
Regulation (regulated) of cAMP response element-binding protein in neuronal
14) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0.19
The fact that vinpocetine treatment was able to restore orientation selectivity in animals early exposed to alcohol suggests that, although NMDA and GABA receptor functions are affected by alcohol [10], [24], [26], [68], [74], [75], the long-lasting alterations in CREB activity seem to be the main cause for the poor development of cortical orientation selectivity.
Regulation (alterations) of CREB associated with gaba receptor and alcohol
15) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2721629 Disease Relevance 0 Pain Relevance 0.43
Tilling-array technology, another new strategy for whole-genome identification of transcription factors binding sites, has been used to identify targets of CREB, an important transcription factor implicated in drug addiction [39].
Regulation (targets) of CREB associated with drug dependence and addiction
16) Confidence 0.07 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2174978 Disease Relevance 0.35 Pain Relevance 0.41
Under the present conditions fentanyl did not affect extracellular signal-regulated protein kinase 1 and 2, Stat and cyclic AMP-response element-binding protein activity.
Neg (not) Regulation (affect) of cyclic AMP-response element-binding protein
17) Confidence 0.06 Published 2003 Journal Neuroscience Section Abstract Doc Link 12535947 Disease Relevance 0 Pain Relevance 0.83
We examined the changes of two transcription factors, CREB and c-Jun, in dorsal root ganglia (DRG) after acute (8 or 48 hours) or chronic (10 days) cyclophosphamide (CYP)-induced cystitis.
Spec (examined) Regulation (changes) of CREB in dorsal root ganglia associated with cystitis
18) Confidence 0.05 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14694538 Disease Relevance 0.42 Pain Relevance 0
A growing body of evidence supports an important role of the transcription factor cAMP responsive element binding protein (CREB) in mediating opioid-induced changes in the cAMP pathway.
Regulation (role) of cAMP responsive element binding protein in body associated with opioid
19) Confidence 0.05 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10708700 Disease Relevance 0 Pain Relevance 0.56
The non-cholinergic mechanisms of chlorpyrifos are not clear, but a possible target may be the signalling cascades involved in neuronal and hormonal inputs, including the cyclic-AMP – protein kinase A cascade, receptor signalling through protein kinase C, and direct effects on the expression and function of nuclear transcription factors mediating the switch from proliferation to differentiation, including c-fos, p53, AP-1, Sp1 and CREB (Ca2+/cAMP response element binding protein) (reviewed in [42]).
Regulation (effects) of CREB in neuronal associated with kinase c
20) Confidence 0.03 Published 2008 Journal Environ Health Section Body Doc Link PMC2577708 Disease Relevance 0.39 Pain Relevance 0.05

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