INT86889

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.23
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cdx2) nucleus (Cdx2) protein complex (Cdx2)
Cdx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 10 89.28 High High
anesthesia 2 87.36 High High
cINOD 12 82.72 Quite High
imagery 3 77.88 Quite High
abdominal pain 2 75.16 Quite High
fibrosis 2 15.68 Low Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mucinous Adenocarcinoma 12 99.98 Very High Very High Very High
Leydig Cell Tumor 13 99.28 Very High Very High Very High
Villous Adenoma 2 99.08 Very High Very High Very High
Cancer 69 98.80 Very High Very High Very High
Carcinoma 17 90.64 High High
Metastasis 2 85.40 High High
Cyst 2 80.40 Quite High
Peritonitis 1 80.40 Quite High
Ductal Carcinoma 1 78.64 Quite High
Abdominal Pain 2 75.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no change in Cdx-2 gene expression.
Gene_expression (expression) of Cdx-2 gene
1) Confidence 0.60 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10712262 Disease Relevance 0 Pain Relevance 0.07
To determine the effect of glucagon-like peptide-2 (GLP-2) on sucrase-isomaltase and caudal-related homeobox protein-2 (Cdx-2) gene expression, male Wistar rats were divided into total parenteral nutrition (TPN)-fed and GLP-2-treated, TPN-fed groups.
Gene_expression (expression) of Cdx-2
2) Confidence 0.60 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10712262 Disease Relevance 0 Pain Relevance 0.09
The mucinous adenocarcinoma expressed positivity for CK20, CEA, CDX2 and CK7, and the SLCT component was positive for inhibin expression.
Gene_expression (expressed) of CDX2 associated with leydig cell tumor and mucinous adenocarcinoma
3) Confidence 0.20 Published 2010 Journal Pathol. Res. Pract. Section Abstract Doc Link 19674851 Disease Relevance 2.03 Pain Relevance 0.11
Whereas SC-560 had no significant effects on the total cellular expression of K(v)1.4 channel protein, indomethacin and NS-398 decreased not only the total cellular expression of K(v)1.4, but also the cell surface expression of both K(v)1.4 and K(v)1.6 channel subunits in IEC-Cdx2.
Gene_expression (expression) of IEC-Cdx2
4) Confidence 0.18 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17499219 Disease Relevance 0 Pain Relevance 0.28
Whereas SC-560 had no significant effects on the total cellular expression of K(v)1.4 channel protein, indomethacin and NS-398 decreased not only the total cellular expression of K(v)1.4, but also the cell surface expression of both K(v)1.4 and K(v)1.6 channel subunits in IEC-Cdx2.
Gene_expression (expression) of IEC-Cdx2
5) Confidence 0.15 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17499219 Disease Relevance 0 Pain Relevance 0.28
It also expresses MUC2 and CDX2 but not MUC1 (Fig. 1a,b).
Neg (not) Gene_expression (expresses) of CDX2
6) Confidence 0.10 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2063564 Disease Relevance 0.85 Pain Relevance 0
Immunohistochemical studies showed that the tumor was positive for CK7, CK19, CEA (both monoclonal/polyclonal) and negative for CK20, CDX2, TTF-1, chromogranin, synaptophysin and Estrogen/Progesterone receptors.


Neg (negative) Gene_expression (negative) of CDX2 associated with cancer
7) Confidence 0.10 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2631453 Disease Relevance 0.78 Pain Relevance 0.18
These cells express MUC5 (Fig. 1g,h), while MUC1, MUC2, or CDX2 positivity is only occasionally observed.
Gene_expression (positivity) of CDX2
8) Confidence 0.09 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2063564 Disease Relevance 0.57 Pain Relevance 0

General Comments

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