INT86890

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 0.38
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Si) plasma membrane (Si) carbohydrate metabolic process (Si)
Anatomy Link Frequency
villus 1
small intestine 1
Si (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 4 99.78 Very High Very High Very High
anesthesia 11 87.92 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 24 95.60 Very High Very High Very High
Body Weight 5 77.68 Quite High
Sperm Disorder 12 27.72 Quite Low
Congenital Anomalies 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Male Infertility 6 5.00 Very Low Very Low Very Low
Immunization 3 5.00 Very Low Very Low Very Low
Aggression 3 5.00 Very Low Very Low Very Low
Emergencies 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression.
Gene_expression (expression) of sucrase-isomaltase
1) Confidence 0.37 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 10712262 Disease Relevance 0 Pain Relevance 0.09
To determine the effect of glucagon-like peptide-2 (GLP-2) on sucrase-isomaltase and caudal-related homeobox protein-2 (Cdx-2) gene expression, male Wistar rats were divided into total parenteral nutrition (TPN)-fed and GLP-2-treated, TPN-fed groups.
Gene_expression (expression) of sucrase-isomaltase
2) Confidence 0.37 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10712262 Disease Relevance 0 Pain Relevance 0.09
In addition, administration of dexamethasone increased expression of sucrase-isomaltase mRNA and trehalase mRNA in the small intestine [11, 22].
Gene_expression (expression) of sucrase-isomaltase in small intestine associated with dexamethasone
3) Confidence 0.31 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0.09
Ileal expression of sucrase-isomaltase was increased by 1. 6-fold (P < 0.05).
Gene_expression (expression) of sucrase-isomaltase
4) Confidence 0.28 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10712262 Disease Relevance 0 Pain Relevance 0.08
However, sucrase activity and sucrase-isomaltase expression increased to control level by 26 days of age although villus area and crypt length still differed between ADX and sham-operated rats at that time.
Gene_expression (expression) of sucrase-isomaltase in villus
5) Confidence 0.28 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
According to the RNAi mechanism-based rules [31], [32], two siRNAs (Hsi1 and Hsi2) targeting the different sites of HongrES1 gene and a non-silencing siRNA (Csi) as scrambled control were designed and synthesized.
Gene_expression (synthesized) of siRNAs
6) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.23 Pain Relevance 0
Cell culture and siRNAs transfection
Gene_expression (transfection) of siRNAs
7) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.08 Pain Relevance 0.06
Two siRNAs (Hsi1 and Hsi2) targeting HongrES1 sequence and non-silencing siRNA (Csi) for scrambled control were synthesized by Shanghai GeneChem Inc (Shanghai, China).
Gene_expression (synthesized) of siRNAs
8) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.08 Pain Relevance 0.06

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