INT86902

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Context Info
Confidence 0.68
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.34
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Mia) extracellular matrix organization (Mia)
Anatomy Link Frequency
neuronal 1
joints 1
neurons 1
knees 1
neural 1
Mia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Mono iodoacetate 70 100.00 Very High Very High Very High
palliative 1 98.92 Very High Very High Very High
Osteoarthritis 124 98.76 Very High Very High Very High
nociceptor 5 98.68 Very High Very High Very High
Dorsal horn 12 97.80 Very High Very High Very High
Pain 65 96.44 Very High Very High Very High
Arthritis 31 96.12 Very High Very High Very High
central sensitization 5 94.36 High High
diclofenac 3 92.92 High High
isoflurane 7 91.92 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 170 98.76 Very High Very High Very High
Gastrointestinal Neoplasms 2 98.40 Very High Very High Very High
Cancer 5 97.96 Very High Very High Very High
Pain 76 96.44 Very High Very High Very High
Carcinoma 4 93.96 High High
Nociception 10 93.72 High High
Arthritis 31 88.72 High High
INFLAMMATION 38 80.76 Quite High
Stress 4 74.04 Quite High
Skin Cancer 2 73.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study shows for the first time that MIA produces a graded sensitization of joint nociceptors making this a useful model for the study of pain mechanisms in joints with progressive OA severity.
Gene_expression (produces) of MIA in joints associated with pain, mono iodoacetate, nociceptor and osteoarthritis
1) Confidence 0.68 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19716399 Disease Relevance 0.97 Pain Relevance 1.30
Elevated serum levels of MIA and S100 are frequent in patients with gastrointestinal cancer.
Gene_expression (levels) of MIA associated with gastrointestinal neoplasms
2) Confidence 0.44 Published 2000 Journal Med. Oncol. Section Abstract Doc Link 10713658 Disease Relevance 0.75 Pain Relevance 0.10
Spinal administration of ondansetron did not produce any significant effects on any of the electrically evoked neuronal responses in either the MIA or vehicle treated rats (data not shown).
Neg (not) Gene_expression (produce) of MIA in neuronal associated with mono iodoacetate
3) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2744671 Disease Relevance 0.09 Pain Relevance 0.45
Second, using DiI, we demonstrated that the SubLC connects directly with the MIA.
Gene_expression (connects) of MIA
4) Confidence 0.39 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1079781 Disease Relevance 0 Pain Relevance 0.33
The aims of the current study were to identify the structures that project to the MIA (and therefore may contribute to the generation of atonia) and to identify supraspinal neural correlates of myoclonic twitching.
Gene_expression (project) of MIA in neural
5) Confidence 0.39 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1079781 Disease Relevance 0.06 Pain Relevance 0.07
Osteoarthritis was induced 21 days prior to electrophysiological testing by injecting 3 mg Monoiodoacetate (MIA, 50 ?
Gene_expression (injecting) of MIA associated with osteoarthritis
6) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2841076 Disease Relevance 0.62 Pain Relevance 0.42
The injection of MIA into the knees of rats provides a model where lesions resemble some aspects of human OA.
Gene_expression (injection) of MIA in knees associated with osteoarthritis
7) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.86 Pain Relevance 0.40
The amounts of MMP were significantly elevated after the injection of MIA.
Gene_expression (injection) of MIA
8) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.98 Pain Relevance 0.47
However, it has remained to address whether other acid-sensitive background K+ channels are functionally expressed in DRG neurons.
Gene_expression (expressed) of acid-sensitive in neurons
9) Confidence 0.02 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16904821 Disease Relevance 0 Pain Relevance 0

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