INT86907

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Context Info
Confidence 0.33
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.76
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (MSH6) ATPase activity (MSH6) nucleus (MSH6)
MSH6 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 98.36 Very High Very High Very High
cINOD 16 97.92 Very High Very High Very High
Opioid 1 90.40 High High
aspirin 4 87.52 High High
chemokine 1 81.56 Quite High
agonist 1 56.96 Quite High
antagonist 2 32.36 Quite Low
endometriosis 30 5.00 Very Low Very Low Very Low
depression 10 5.00 Very Low Very Low Very Low
abdominal pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 214 99.76 Very High Very High Very High
Cancer 858 98.34 Very High Very High Very High
Hereditary Nonpolyposis Colorectal Neoplasms 312 97.16 Very High Very High Very High
Apoptosis 46 96.04 Very High Very High Very High
Colorectal Cancer 66 96.00 Very High Very High Very High
Adhesions 1 88.80 High High
Colon Cancer 493 87.44 High High
Endometriosis (extended) 37 86.88 High High
Leukemia 1 86.40 High High
Syndrome 77 77.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MSH6 DNA mismatch repair protein MSH6
Negative_regulation (repair) of MSH6
1) Confidence 0.33 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.70 Pain Relevance 0.40
So far, the genetic alterations in Chinese HNPCC appear similar to those in Western countries; however, there are no data yet on the prevalence of Chinese MSH6 and PMS2 gene mutations.
Negative_regulation (prevalence) of MSH6
2) Confidence 0.33 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837058 Disease Relevance 0.19 Pain Relevance 0
MSI frequency in cells deficient of MMR genes (hMSH2, hMLH1, hMSH6) was markedly reduced after long-term (> 10 weeks) NSAID treatment.
Negative_regulation (deficient) of hMSH6 associated with cinod and microsatellite instability
3) Confidence 0.11 Published 1999 Journal Verh Dtsch Ges Pathol Section Abstract Doc Link 10714217 Disease Relevance 1.32 Pain Relevance 0.53
In this group of non-familial CRCs, 17% had defects in DNA MMR protein expression, and 57% were atypical, with isolated losses of hMSH6 or hPMS2.
Negative_regulation (losses) of hMSH6
4) Confidence 0.01 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.85 Pain Relevance 0
Unlike classic Lynch syndrome, only 43% (6/14) of these MMR-deficient CRCs (by IHC) demonstrated loss of expression of one of the two major DNA MMR proteins, hMLH1 or hMSH2 (3 each for hMLH1 and hMSH2), together with the associated losses of hPMS2 or hMSH6.
Negative_regulation (losses) of hMSH6 associated with hereditary nonpolyposis colorectal neoplasms
5) Confidence 0.01 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 1.01 Pain Relevance 0
While all 9 tumors with hMLH1, hMSH2, or hPMS2 losses were MSI-H, only 2/5 of the CRCs with isolated losses of hMSH6 were MSI-H; in both cases, just 3/5 markers were mutated and in the other three, none were mutated.
Negative_regulation (losses) of hMSH6 associated with cancer and microsatellite instability
6) Confidence 0.01 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.91 Pain Relevance 0
Some (3/5) of the CRCs with isolated losses of hMSH6 were MSS, and will be missed by approaches that use MSI to screen for Lynch syndrome.
Negative_regulation (losses) of hMSH6 associated with microsatellite instability and hereditary nonpolyposis colorectal neoplasms
7) Confidence 0.01 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.88 Pain Relevance 0
Of particular note, 8/14 (57%) of the MMR-deficient CRCs had experienced the exclusive loss of either hPMS2 (n = 3) or hMSH6 (n = 5), without the respective loss of expression of hMLH1 or hMSH2.
Negative_regulation (loss) of hMSH6
8) Confidence 0.00 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.89 Pain Relevance 0

General Comments

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