INT86908

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Context Info
Confidence 0.43
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.98
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (MLH1) nucleus (MLH1) cell cycle (MLH1)
Anatomy Link Frequency
MLH1 3
GALT 1
MLH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 6 100.00 Very High Very High Very High
cINOD 8 97.64 Very High Very High Very High
endometriosis 8 91.36 High High
aspirin 4 87.52 High High
Taxol 2 66.76 Quite High
abdominal pain 3 16.08 Low Low
COX2 1 12.00 Low Low
depression 2 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 6 100.00 Very High Very High Very High
Cancer 383 99.88 Very High Very High Very High
Microsatellite Instability 109 99.76 Very High Very High Very High
Colon Cancer 132 99.40 Very High Very High Very High
Endometrial Cancer 165 99.16 Very High Very High Very High
Colorectal Cancer 53 97.60 Very High Very High Very High
Apoptosis 32 96.04 Very High Very High Very High
Endometriosis (extended) 12 91.36 High High
Leukemia 1 86.32 High High
Aging 1 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry (IHC) on surgical specimens was as follows: MLH1 stained negative and MSH2 stained positive in all tumors (Fig. 3), strongly suggesting a mutation in MLH1.
Negative_regulation (mutation) of MLH1 in MLH1 associated with cancer
1) Confidence 0.43 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 0.95 Pain Relevance 0.03
Unlike HNPCC associated colorectal carcinoma, which appears to frequently have MLH1 and MSH2 mutations, endometrial carcinomas have a higher probability of MSH2 and MSH6 mutations [13, 25].
Negative_regulation (have) of MLH1 in MLH1 associated with colon cancer and endometrial cancer
2) Confidence 0.36 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.66 Pain Relevance 0
Aberrant methylation can begin very early in tumor progression by causing loss of cell cycle control (p16) [83], loss of mismatch repair function (MLH1) [84] and loss of cell-cell interaction (E-cadherin).
Negative_regulation (loss) of MLH1 in MLH1 associated with cancer
3) Confidence 0.19 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.72 Pain Relevance 0
They found in cell lines that were CIMP+ there was widespread silencing of genes through promoter methylation which they hypothesised could also cause inactivation of the hMLH1 promoter and thus may play a role in up to 75% of sporadic colorectal carcinoma cases that are MSI+.
Negative_regulation (inactivation) of hMLH1 associated with colorectal cancer
4) Confidence 0.10 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.76 Pain Relevance 0
MSI frequency in cells deficient of MMR genes (hMSH2, hMLH1, hMSH6) was markedly reduced after long-term (> 10 weeks) NSAID treatment.
Negative_regulation (deficient) of hMLH1 associated with cinod and microsatellite instability
5) Confidence 0.10 Published 1999 Journal Verh Dtsch Ges Pathol Section Abstract Doc Link 10714217 Disease Relevance 1.32 Pain Relevance 0.53
Loss of heterozygosity in adenomyosis on hMSH2, hMLH1, p16Ink4 and GALT loci.
Negative_regulation (Loss) of hMLH1 in GALT associated with dismenorea
6) Confidence 0.03 Published 2000 Journal Int. J. Mol. Med. Section Title Doc Link 11078826 Disease Relevance 0.74 Pain Relevance 0.56
While all 9 tumors with hMLH1, hMSH2, or hPMS2 losses were MSI-H, only 2/5 of the CRCs with isolated losses of hMSH6 were MSI-H; in both cases, just 3/5 markers were mutated and in the other three, none were mutated.
Negative_regulation (losses) of hMLH1 associated with cancer and microsatellite instability
7) Confidence 0.01 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.83 Pain Relevance 0

General Comments

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