INT8691

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Context Info
Confidence 0.80
First Reported 1984
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 85
Total Number 87
Disease Relevance 9.27
Pain Relevance 30.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
amygdala 13
neurons 9
plasma 5
NIL 3
dendrites 2
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 98 100.00 Very High Very High Very High
Somatostatin 56 100.00 Very High Very High Very High
substance P 30 100.00 Very High Very High Very High
Calcitonin gene-related peptide 24 100.00 Very High Very High Very High
mu opioid receptor 22 100.00 Very High Very High Very High
opiate 17 99.92 Very High Very High Very High
dexamethasone 8 99.80 Very High Very High Very High
Raphe 7 99.78 Very High Very High Very High
noradrenaline 7 99.56 Very High Very High Very High
amygdala 51 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperinsulinism 1 100.00 Very High Very High Very High
Ganglion Cysts 32 99.48 Very High Very High Very High
Insulin Resistance 25 99.44 Very High Very High Very High
Diabetes Mellitus 700 99.24 Very High Very High Very High
Disorder Of Lipid Metabolism 10 99.20 Very High Very High Very High
Neurogenic Inflammation 3 98.40 Very High Very High Very High
Nicotine Addiction 2 97.92 Very High Very High Very High
Blister 3 97.84 Very High Very High Very High
Metabolic Disorder 6 96.92 Very High Very High Very High
Hyperalgesia 1 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoreactive (IR)-Met-enkephalin (IR-ME), IR-Leu-enkephalin (IR-LE), IR-heptapeptide (IR-HE), IR-octapeptide (IR-OC) and IR-synenkephalin (IR-Syn) in vitro release was measured from amygdala slices 24 h after the last stimulus, in groups of eight rats, every 4 h beginning at 08:00 h.
Localization (release) of IR-synenkephalin in amygdala associated with enkephalin and amygdala
1) Confidence 0.80 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.52
IR-LE and IR-OC release was enhanced 4 h later (20:00 h), no changes were detected for IR-HE.
Localization (release) of IR-OC
2) Confidence 0.80 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.55
Immunoreactive (IR)-Met-enkephalin (IR-ME), IR-Leu-enkephalin (IR-LE), IR-heptapeptide (IR-HE), IR-octapeptide (IR-OC) and IR-synenkephalin (IR-Syn) in vitro release was measured from amygdala slices 24 h after the last stimulus, in groups of eight rats, every 4 h beginning at 08:00 h.
Localization (release) of IR-Syn in amygdala associated with enkephalin and amygdala
3) Confidence 0.80 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.52
IR-LE and IR-OC release was enhanced 4 h later (20:00 h), no changes were detected for IR-HE.
Localization (release) of IR-LE
4) Confidence 0.80 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.55
Immunoreactive (IR)-Met-enkephalin (IR-ME), IR-Leu-enkephalin (IR-LE), IR-heptapeptide (IR-HE), IR-octapeptide (IR-OC) and IR-synenkephalin (IR-Syn) in vitro release was measured from amygdala slices 24 h after the last stimulus, in groups of eight rats, every 4 h beginning at 08:00 h.
Localization (release) of IR-octapeptide in amygdala associated with enkephalin and amygdala
5) Confidence 0.70 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.52
Immunoreactive (IR)-Met-enkephalin (IR-ME), IR-Leu-enkephalin (IR-LE), IR-heptapeptide (IR-HE), IR-octapeptide (IR-OC) and IR-synenkephalin (IR-Syn) in vitro release was measured from amygdala slices 24 h after the last stimulus, in groups of eight rats, every 4 h beginning at 08:00 h.
Localization (release) of IR-HE in amygdala associated with enkephalin and amygdala
6) Confidence 0.70 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.52
Immunoreactive (IR)-Met-enkephalin (IR-ME), IR-Leu-enkephalin (IR-LE), IR-heptapeptide (IR-HE), IR-octapeptide (IR-OC) and IR-synenkephalin (IR-Syn) in vitro release was measured from amygdala slices 24 h after the last stimulus, in groups of eight rats, every 4 h beginning at 08:00 h.
Localization (release) of IR-OC in amygdala associated with enkephalin and amygdala
7) Confidence 0.70 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.52
Immunoreactive (IR)-Met-enkephalin (IR-ME), IR-Leu-enkephalin (IR-LE), IR-heptapeptide (IR-HE), IR-octapeptide (IR-OC) and IR-synenkephalin (IR-Syn) in vitro release was measured from amygdala slices 24 h after the last stimulus, in groups of eight rats, every 4 h beginning at 08:00 h.
Localization (release) of IR-Leu-enkephalin in amygdala associated with enkephalin and amygdala
8) Confidence 0.70 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.52
Immunoreactive (IR)-Met-enkephalin (IR-ME), IR-Leu-enkephalin (IR-LE), IR-heptapeptide (IR-HE), IR-octapeptide (IR-OC) and IR-synenkephalin (IR-Syn) in vitro release was measured from amygdala slices 24 h after the last stimulus, in groups of eight rats, every 4 h beginning at 08:00 h.
Localization (release) of IR-LE in amygdala associated with enkephalin and amygdala
9) Confidence 0.70 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.52
Immunoreactive (IR)-Met-enkephalin (IR-ME), IR-Leu-enkephalin (IR-LE), IR-heptapeptide (IR-HE), IR-octapeptide (IR-OC) and IR-synenkephalin (IR-Syn) in vitro release was measured from amygdala slices 24 h after the last stimulus, in groups of eight rats, every 4 h beginning at 08:00 h.
Localization (release) of IR-heptapeptide in amygdala associated with enkephalin and amygdala
10) Confidence 0.70 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.52
Immunoreactive (IR)-Met-enkephalin (IR-ME), IR-Leu-enkephalin (IR-LE), IR-heptapeptide (IR-HE), IR-octapeptide (IR-OC) and IR-synenkephalin (IR-Syn) in vitro release was measured from amygdala slices 24 h after the last stimulus, in groups of eight rats, every 4 h beginning at 08:00 h.
Localization (release) of IR-ME in amygdala associated with enkephalin and amygdala
11) Confidence 0.70 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.52
In the raphe nuclei no colocalization of 5-HT-IR and TH-IR was observed.
Localization (colocalization) of TH-IR associated with raphe
12) Confidence 0.69 Published 1995 Journal Brain Res. Section Abstract Doc Link 7712183 Disease Relevance 0 Pain Relevance 0.58
We were unable to find DMP-IR in guinea pig, rat and toad brain and rat and toad spinal cord either extracted with methanol or with HCl.
Neg (unable) Spec (find) Localization (find) of DMP-IR in brain associated with spinal cord
13) Confidence 0.68 Published 1985 Journal Neuropeptides Section Abstract Doc Link 4000417 Disease Relevance 0 Pain Relevance 0.14
The basal release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is doubled by the in vitro addition of 5 X 10(-5) M dopamine.
Localization (release) of ME-IR associated with dopamine and enkephalin
14) Confidence 0.67 Published 1984 Journal Brain Res. Section Abstract Doc Link 6697225 Disease Relevance 0 Pain Relevance 0.48
Neuroleptics do not alter the basal or the K+-stimulated ME-IR release but reverse the dopamine-induced increase.
Localization (release) of ME-IR associated with dopamine
15) Confidence 0.67 Published 1984 Journal Brain Res. Section Abstract Doc Link 6697225 Disease Relevance 0 Pain Relevance 0.53
The K+ evoked release of ME-IR is also slightly enhanced by exposing the slices to dopamine.
Localization (release) of ME-IR associated with dopamine
16) Confidence 0.67 Published 1984 Journal Brain Res. Section Abstract Doc Link 6697225 Disease Relevance 0 Pain Relevance 0.50
Serotonin (5-HT) and noradrenaline (NA), did not affect ME-IR release.
Localization (release) of ME-IR associated with noradrenaline and serotonin
17) Confidence 0.65 Published 1984 Journal Peptides Section Abstract Doc Link 6209687 Disease Relevance 0 Pain Relevance 0.69
The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dioxy 3, 4-benzyl-4-piperazine) a psychostimulant drug with mild dopaminomimetic activity.
Localization (release) of ME-IR associated with enkephalin
18) Confidence 0.64 Published 1986 Journal Brain Res. Section Abstract Doc Link 2879607 Disease Relevance 0 Pain Relevance 0.20
Both amphetamine and fipexide inhibited in vitro the release of ME-IR.
Localization (release) of ME-IR
19) Confidence 0.64 Published 1986 Journal Brain Res. Section Abstract Doc Link 2879607 Disease Relevance 0 Pain Relevance 0.20
The release of G-IR in the portal effluent was 40-fold lower than that of G-IR into the luminal perfusate.
Localization (release) of G-IR
20) Confidence 0.61 Published 2000 Journal Endocrinology Section Abstract Doc Link 10875263 Disease Relevance 0 Pain Relevance 0.18

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