INT86910

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Context Info
Confidence 0.20
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.52
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (MRC1) plasma membrane (MRC1)
Anatomy Link Frequency
dendritic cell 1
upper 1
MRC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 68 99.84 Very High Very High Very High
cINOD 6 96.84 Very High Very High Very High
aspirin 4 87.52 High High
Inflammatory response 1 60.92 Quite High
Arthritis 15 53.52 Quite High
Inflammation 22 53.12 Quite High
metalloproteinase 1 29.32 Quite Low
alcohol 38 25.52 Quite Low
imagery 4 16.80 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 68 99.84 Very High Very High Very High
Microsatellite Instability 22 99.60 Very High Very High Very High
Reprotox - General 1 14 99.38 Very High Very High Very High
Systemic Lupus Erythematosus 84 99.18 Very High Very High Very High
Cancer 75 98.76 Very High Very High Very High
Stress 19 98.32 Very High Very High Very High
Adhesions 9 98.28 Very High Very High Very High
Disease 91 96.08 Very High Very High Very High
Apoptosis 13 96.04 Very High Very High Very High
Syndrome 7 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, IHC staining detects the loss of an MMR protein in 78-87% of upper urothelial cancers with demonstrated MSI [23,24], most commonly MSH2 and MSH6 [25].
Negative_regulation (loss) of MMR protein in upper associated with cancer and microsatellite instability
1) Confidence 0.20 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 1.20 Pain Relevance 0
Abolition of MMR raises the basal rate of mutation and leads to microsatellite instability (MSI), a tissue marker of defective mismatch repair [9].
Negative_regulation (Abolition) of MMR associated with microsatellite instability
2) Confidence 0.20 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 1.46 Pain Relevance 0
MSI frequency in cells deficient of MMR genes (hMSH2, hMLH1, hMSH6) was markedly reduced after long-term (> 10 weeks) NSAID treatment.
Negative_regulation (deficient) of MMR associated with cinod and microsatellite instability
3) Confidence 0.16 Published 1999 Journal Verh Dtsch Ges Pathol Section Abstract Doc Link 10714217 Disease Relevance 1.32 Pain Relevance 0.52
Attention in reproductive health care, such as the use of contraceptive methods, decreasing fertility, expanding inter-pregnancy intervals, and providing safe abortion care may have great impact in reducing MMR and in improving womenÂ’s health.


Negative_regulation (reducing) of MMR associated with reprotox - general 1
4) Confidence 0.07 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898047 Disease Relevance 0.64 Pain Relevance 0
Major efforts to control and reduce MMR in Cuba include: continued training of maternity personnel; major emphasis to primary health; and creation and expansion of clinics, hospitals, and health centers in the country [62].
Negative_regulation (reduce) of MMR
5) Confidence 0.07 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898047 Disease Relevance 0.05 Pain Relevance 0
Such mutagenesis is normally corrected by DNA repair systems including the mismatch repair (MMR) system; however, the MMR system is defective in RA, probably due in part to oxidative stress.
Negative_regulation (defective) of MMR associated with stress and rheumatoid arthritis
6) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.95 Pain Relevance 0.28
When compared with dendritic cells from healthy control individuals, unstimulated and stimulated lupus dendritic cells displayed significantly decreased dextran uptake and mannose receptor and dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin expression.
Negative_regulation (decreased) of mannose receptor in dendritic cell associated with systemic lupus erythematosus and adhesions
7) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2592801 Disease Relevance 0.91 Pain Relevance 0

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