INT86914

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 4.73
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Smpd1) hydrolase activity, acting on glycosyl bonds (Smpd1) lysosome (Smpd1)
Anatomy Link Frequency
liver 3
ASM 1
lungs 1
mast cell 1
Smpd1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 8 99.48 Very High Very High Very High
Inflammation 65 98.06 Very High Very High Very High
Kinase C 2 97.60 Very High Very High Very High
cytokine 77 93.44 High High
ischemia 18 89.16 High High
Inflammatory response 11 87.20 High High
Paracetamol 3 83.68 Quite High
aspirin 1 77.12 Quite High
cINOD 2 74.48 Quite High
Endep 1 50.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 76 99.52 Very High Very High Very High
Cystic Fibrosis 8 99.48 Very High Very High Very High
Asthma 62 99.16 Very High Very High Very High
INFLAMMATION 73 98.06 Very High Very High Very High
Death 5 96.16 Very High Very High Very High
Hepatotoxicity 2 95.76 Very High Very High Very High
Myocardial Infarction 5 92.04 High High
Stress 22 90.40 High High
Ischemic Heart Disease 6 89.16 High High
Pulmonary Disease 1 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some organic weak bases induce a detachment from inner lysosomal membranes and subsequent inactivation of acid sphingomyelinase (ASM) and thus work as functional ASM inhibitors.
Positive_regulation (inactivation) of ASM
1) Confidence 0.43 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18027916 Disease Relevance 0 Pain Relevance 0
The activity of acidic SMase was enhanced by fumonisin B1, accompanied with a decrease in liver SM content.
Positive_regulation (enhanced) of SMase in liver
2) Confidence 0.41 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.08
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Positive_regulation (enzymes) of SMase in liver
3) Confidence 0.41 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.06
We tested whether inhalation of different acid sphingomyelinase inhibitors does reduce Asm activity and ceramide accumulation in lungs of CF mice.
Spec (whether) Positive_regulation (accumulation) of Asm in lungs associated with fibrosis
4) Confidence 0.41 Published 2010 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 19635928 Disease Relevance 0.74 Pain Relevance 0.35
Some organic weak bases induce a detachment from inner lysosomal membranes and subsequent inactivation of acid sphingomyelinase (ASM) and thus work as functional ASM inhibitors.
Positive_regulation (inactivation) of sphingomyelinase
5) Confidence 0.37 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18027916 Disease Relevance 0 Pain Relevance 0
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Positive_regulation (enzymes) of sphingomyelinase in liver
6) Confidence 0.35 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.06
This is in agreement with in vitro studies, and with previous reports indicating a major role for acid SMase and the FADD-caspase pathway in TNF?
Positive_regulation (role) of SMase
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.60 Pain Relevance 0.04
activation of ASM and contribute to the development of AHR.
Positive_regulation (activation) of ASM in ASM
8) Confidence 0.23 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.88 Pain Relevance 0.15
to normal subjects led to the development of AHR.19 A postmortem study of fatal and nonfatal asthma showed a marked increase of mast cell degranulation in the airway smooth muscle (ASM) bundle in both the large and small airways,25 and increased numbers of mast cells are associated with increased ASM shortening in fatal asthma.26 Therefore, it is likely that the close proximity of these cells will facilitate mast cell-derived TNF-?
Positive_regulation (increased) of ASM in mast cell associated with asthma
9) Confidence 0.23 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.99 Pain Relevance 0.16
and IL-6 contribute to cardiac dysfunction through activation of neutral sphingomyelinase and NO production [26,27].
Positive_regulation (activation) of sphingomyelinase
10) Confidence 0.02 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1933437 Disease Relevance 0.46 Pain Relevance 0.30
Further studies revealed that an early step in apoptosis was the formation of ceramide from sphingomyelin, resulting from the activation of a neutral pH sphingomyelinase activity.
Positive_regulation (activation) of sphingomyelinase associated with apoptosis
11) Confidence 0.00 Published 2000 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 10715579 Disease Relevance 0.37 Pain Relevance 0.09
The putative chemopreventive actions include the inhibition of inflammatory cascades and/or reactions involved in cell growth and proliferation, such as cyclo-oxygenase (COX-1 and COX-2), which regulate cell proliferation through the formation of prostaglandins; lipoxygenase; nuclear factor kappaB (NFkappaB), responsible for the subsequent expression of pro-inflammatory molecules; MAP kinases and Bcl-2, as well as the activation of apoptotic processes, such as the stimulation of intestinal sphingomyelinase.
Positive_regulation (stimulation) of intestinal sphingomyelinase associated with inflammation and apoptosis
12) Confidence 0.00 Published 2003 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 12950415 Disease Relevance 0.69 Pain Relevance 0.44

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