INT86919

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 21.16
Pain Relevance 3.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
Anatomy Link Frequency
endothelial cells 3
monocytes 1
cerebral hemispheres 1
neurons 1
cleavage 1
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 30 100.00 Very High Very High Very High
Inflammation 97 98.96 Very High Very High Very High
rheumatoid arthritis 3 98.76 Very High Very High Very High
Morphine 11 97.94 Very High Very High Very High
cINOD 53 97.68 Very High Very High Very High
cytokine 96 93.44 High High
aspirin 9 89.76 High High
opioid receptor 2 75.00 Quite High
chemokine 17 71.12 Quite High
opiate 1 69.16 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 724 99.68 Very High Very High Very High
Colon Cancer 83 99.48 Very High Very High Very High
Stress 135 99.32 Very High Very High Very High
Pancreatic Cancer 21 99.08 Very High Very High Very High
Breast Cancer 146 99.00 Very High Very High Very High
INFLAMMATION 138 98.96 Very High Very High Very High
Toxicity 102 98.90 Very High Very High Very High
Rheumatoid Arthritis 3 98.76 Very High Very High Very High
Lung Cancer 68 98.68 Very High Very High Very High
Cancer 620 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of PI3K/Akt inhibition and p27 upregulation, as well as hypophosphorylation of Rac1 at ser71, were demonstrated.
Negative_regulation (inhibition) of PI3K
1) Confidence 0.57 Published 2010 Journal Mol. Carcinog. Section Abstract Doc Link 19908241 Disease Relevance 0.96 Pain Relevance 0.46
We subsequently examined the effects of treating the human pancreatic cancer cell lines BxPC-3 and PaCa-2 with a specific inhibitor of the PI3K/Akt pathway, LY294002, in the presence or absence of the NSAID sulindac.
Negative_regulation (inhibitor) of PI3K in BxPC-3 associated with pancreatic cancer and cinod
2) Confidence 0.55 Published 2003 Journal J. Gastrointest. Surg. Section Abstract Doc Link 12654560 Disease Relevance 0.56 Pain Relevance 0.42
In addition, morphine-induced apoptosis seems to be dependent on the activation of phosphatidylinositol 3-kinase (PI3K), as PI3K inhibition by the PI3K inhibitor LY294002 significantly enhanced morphine-induced apoptosis.
Negative_regulation (inhibition) of PI3K associated with apoptosis and morphine
3) Confidence 0.54 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 1.08 Pain Relevance 0.92
The effects of LY294002 (LY29) and wortmannin (WM), inhibitors of phosphatidylinositol 3-kinase (PI3K), on monocyte chemoattractant protein-1 (MCP-1) expression by human umbilical vein endothelial cells were investigated.
Negative_regulation (inhibitors) of phosphatidylinositol 3-kinase in endothelial cells
4) Confidence 0.49 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0 Pain Relevance 0
The effects of LY294002 (LY29) and wortmannin (WM), inhibitors of phosphatidylinositol 3-kinase (PI3K), on monocyte chemoattractant protein-1 (MCP-1) expression by human umbilical vein endothelial cells were investigated.
Negative_regulation (inhibitors) of PI3K in endothelial cells
5) Confidence 0.49 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0 Pain Relevance 0
PI3K inhibition by LY294002 showed an increase in NAG-1 protein and mRNA expression, and 1l-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate (AKT inhibitor) also induced NAG-1 expression.
Negative_regulation (inhibition) of PI3K
6) Confidence 0.46 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15377673 Disease Relevance 0.58 Pain Relevance 0.24
In this report, we showed a PI3K/AKT/glycogen synthase kinase-3beta (GSK-3beta) pathway regulates NAG-1 expression in human colorectal cancer cells as assessed by the inhibition of PI3K, AKT, and GSK-3beta.
Negative_regulation (inhibition) of PI3K associated with colon cancer
7) Confidence 0.46 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15377673 Disease Relevance 0.59 Pain Relevance 0.24
Taken together, our results suggest that inhibition of the PI3K/Akt signaling pathway may sensitize pancreatic tumor cells to therapy with NSAIDs such as sulindac.
Negative_regulation (inhibition) of PI3K associated with pancreatic cancer and cinod
8) Confidence 0.40 Published 2003 Journal J. Gastrointest. Surg. Section Abstract Doc Link 12654560 Disease Relevance 0.53 Pain Relevance 0.22
This subset of cancers may be resistant to strategies targeting upstream growth factor receptors, but particularly sensitive to PI3K or mTOR inhibition.
Negative_regulation (inhibition) of PI3K associated with cancer
9) Confidence 0.37 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.59 Pain Relevance 0
While PI3K inhibitors are still in the early stages of development, mTOR inhibitors are currently being tested in combination with endocrine therapies.
Negative_regulation (inhibitors) of PI3K
10) Confidence 0.37 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.56 Pain Relevance 0
In light of the recent progress in the development of selective PI3K inhibitors, and the beneficial effects of these inhibitors in models of acute and chronic inflammatory disorders, we discuss the therapeutic potential of blocking PI3K isoforms for the treatment of rheumatoid arthritis and other immune-mediated diseases.
Negative_regulation (blocking) of PI3K associated with inflammation, rheumatoid arthritis and disease
11) Confidence 0.29 Published 2007 Journal Nat. Rev. Immunol. Section Abstract Doc Link 17290298 Disease Relevance 0.76 Pain Relevance 0.38
PI3K, AKT, and mTOR have been targeted individually by various drugs, but XL765 is the first oral dual PI3K and mTOR inhibitor with Phase I trial results, reported by Papadopoulos et al [25].
Negative_regulation (inhibitor) of PI3K
12) Confidence 0.28 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.77 Pain Relevance 0
A further 15% to 35% of breast cancer patients demonstrate reduced expression of PTEN (phosphatase and tensin homolog deleted on chromosome ten), an endogenous inhibitor of the PI3K/Akt pathway [47].
Negative_regulation (inhibitor) of PI3K associated with breast cancer
13) Confidence 0.27 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.55 Pain Relevance 0
A cooperative effect was observed between small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K) and Onconase in the killing of MM cells.
Negative_regulation (inhibitors) of PI3K associated with lung cancer
14) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2829496 Disease Relevance 1.24 Pain Relevance 0
kinase (PI3K)/Akt is blocked (Rusnak et al 2001).
Negative_regulation (blocked) of PI3K
15) Confidence 0.22 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727787 Disease Relevance 0.48 Pain Relevance 0
Several compounds in preclinical and clinical trials have targeted various stages of the Ras signaling cascade, including inhibition of Ras expression via antisense oligo-deoxynucleotides, interference via farnesyltransferase inhibitors, and inhibition of Ras downstream effectors via MEK, PI3K inhibitors, and others.
Negative_regulation (inhibitors) of PI3K
16) Confidence 0.20 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.73 Pain Relevance 0.04
The present results confirm that PI 3-K inhibition with Wortmannin and LY294002 induce apoptosis (Fig. 1).
Negative_regulation (inhibition) of PI 3-K associated with apoptosis
17) Confidence 0.17 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.80 Pain Relevance 0
PI 3-K inhibition in RL 95-2 and Ishikawa cells directly blocked Akt phosphorylation and caused a reduction of COX-2 mRNA and protein [42].
Negative_regulation (inhibition) of PI 3-K
18) Confidence 0.17 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.47 Pain Relevance 0
Inhibition of PI 3-K induces apoptosis
Negative_regulation (Inhibition) of PI 3-K associated with apoptosis
19) Confidence 0.17 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.83 Pain Relevance 0
mutated on chromosome ten (PTEN), a negative regulator of PI3K ?
Negative_regulation (regulator) of PI3K
20) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.33 Pain Relevance 0.04

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