INT8694

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 38
Total Number 39
Disease Relevance 14.82
Pain Relevance 8.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Lgals3) extracellular region (Lgals3) mRNA processing (Lgals3)
proteinaceous extracellular matrix (Lgals3) plasma membrane (Lgals3) nucleus (Lgals3)
Anatomy Link Frequency
neurons 3
macrophages 2
Langerhans cell 2
reticulum 2
spinal cord 2
Lgals3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 1 99.90 Very High Very High Very High
qutenza 24 99.62 Very High Very High Very High
Spinal cord 39 99.52 Very High Very High Very High
lumbar region 2 99.22 Very High Very High Very High
Dorsal horn 32 99.20 Very High Very High Very High
Calcitonin gene-related peptide 11 99.04 Very High Very High Very High
dorsal root ganglion 5 98.98 Very High Very High Very High
unmyelinated 14 98.94 Very High Very High Very High
Morphine 3 98.92 Very High Very High Very High
Trigeminal ganglion neurons 6 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 41 99.60 Very High Very High Very High
Anaphylaxis 4 99.44 Very High Very High Very High
Adhesions 32 99.08 Very High Very High Very High
Asthma 18 98.86 Very High Very High Very High
Diabetic Retinopathy 162 98.80 Very High Very High Very High
Insulin Resistance 4 98.60 Very High Very High Very High
INFLAMMATION 259 98.16 Very High Very High Very High
Recurrence 33 98.08 Very High Very High Very High
Cancer 12 97.28 Very High Very High Very High
Conjunctiva Disease 54 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Direct antibody binding and hapten inhibition studies revealed that morphine, which contains a tertiary amino group, was strongly recognized by IgE in sera from anaphylactic patients and a morphine-solid phase immunoassay was found to be superior to NMBD-based assays for the detection of NMBD-reactive IgE antibodies.
IgE Binding (recognized) of in superior associated with anaphylaxis and morphine
1) Confidence 0.48 Published 2009 Journal Clin. Exp. Allergy Section Abstract Doc Link 19187323 Disease Relevance 0.41 Pain Relevance 0.26
Electron microscopy of the somata of retrogradely labelled neurones showed the lectin to be associated with the inner surface of cytoplasmic vesicles, supporting the premise that the uptake of BSI-B(4) into sensory neurones is by the process of receptor-mediated endocytosis.
lectin Binding (associated) of in vesicles
2) Confidence 0.45 Published 2004 Journal Neuroscience Section Abstract Doc Link 15219679 Disease Relevance 0 Pain Relevance 0.11
Light and electron microscopy revealed transganglionically transported and bound lectin in the superficial dorsal horn and dorsolateral funiculus of the L3 and L4 segments of spinal cord.
lectin Binding (bound) of in spinal cord associated with dorsal horn and spinal cord
3) Confidence 0.44 Published 2004 Journal J. Neurol. Sci. Section Abstract Doc Link 15178216 Disease Relevance 0.08 Pain Relevance 0.59
In this study, we used THP-1-derived macrophages to investigate the effects of non-steroidal anti-inflammatory drugs (aspirin and indomethacin) and glucocorticoids (hydrocortisone and dexamethasone) on galectin-3, a multifunctional beta-galactoside binding lectin, which in general acts as a strong pro-inflammatory signal.
galectin-3 Binding (binding) of in macrophages associated with aspirin, inflammation, cinod and dexamethasone
4) Confidence 0.35 Published 2006 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16458432 Disease Relevance 0.20 Pain Relevance 0.25
Longitudinal sections of the thoraco-lumbar region of spinal cord were also examined for lectin binding.
lectin Spec (examined) Binding (binding) of in spinal cord associated with lumbar region and spinal cord
5) Confidence 0.34 Published 2004 Journal J. Neurol. Sci. Section Abstract Doc Link 15178216 Disease Relevance 0.08 Pain Relevance 0.58
An ultrastructural study of the binding of an alpha-D-galactose specific lectin from Griffonia simplicifolia to trigeminal ganglion neurons and the trigeminal nucleus caudalis in the rat.
lectin Binding (binding) of in nucleus associated with ganglion cysts and trigeminal ganglion neurons
6) Confidence 0.34 Published 1993 Journal Neuroscience Section Title Doc Link 8450967 Disease Relevance 0.44 Pain Relevance 0.13
This lectin bound to small ganglion neurons with two different binding patterns.
lectin Binding (bound) of in neurons associated with ganglion cysts
7) Confidence 0.34 Published 1993 Journal Neuroscience Section Abstract Doc Link 8450967 Disease Relevance 0.44 Pain Relevance 0.12
Lgals3 (lectin, galactoside-binding, soluble 3; galectin-3) is an abundant protein expressed in the nucleus, cytoplasm, mitochondria, and plasma membrane of multiple cell types including inflammatory macrophages [59], retinal Müller glia [30] and endothelial cells [60].
galectin-3 Binding (binding) of in inflammatory macrophages associated with inflammation
8) Confidence 0.32 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.54 Pain Relevance 0.05
Lgals3 (lectin, galactoside-binding, soluble 3; galectin-3) is an abundant protein expressed in the nucleus, cytoplasm, mitochondria, and plasma membrane of multiple cell types including inflammatory macrophages [59], retinal Müller glia [30] and endothelial cells [60].
soluble 3 Binding (binding) of in inflammatory macrophages associated with inflammation
9) Confidence 0.32 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.54 Pain Relevance 0.05
LGALS3BP (lectin, galactosidase-binding, soluble, 3, binding protein), is a cell adhesion binding protein for LGALS3 and is elevated in patients with DR [13].
lectin Binding (binding) of associated with diabetic retinopathy and adhesions
10) Confidence 0.30 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.32 Pain Relevance 0.27
LGALS3 (lectin, galactosidase-binding, soluble, 3), also known as GAL3 (galectin 3), plays many roles in inflammatory responses as an advanced glycation end-products (AGE) receptor [41].
lectin Binding (binding) of associated with inflammatory response
11) Confidence 0.30 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.15 Pain Relevance 0.22
LGALS3 (lectin, galactosidase-binding, soluble, 3), also known as GAL3 (galectin 3), plays many roles in inflammatory responses as an advanced glycation end-products (AGE) receptor [41].
LGALS3 Binding (binding) of associated with inflammatory response
12) Confidence 0.30 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.15 Pain Relevance 0.24
There are no reported data describing the role of LAMA5 (Laminin, alpha-5) retina, however, laminin-LGALS3 interactions can promote leukocyte adhesion [44].
LGALS3 Binding (interactions) of in retina associated with adhesions
13) Confidence 0.30 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.35 Pain Relevance 0.24
Four gene-to-gene interactions (S100 Calpactin [S100a10] with annexin A2 [Anxa2], Lectin, galactose binding, soluble 3 [Lgals3] with Epidermal Langerhans cell protein [Lcp1], Tumor protein p53 [TP53] with Cathepsin H [Ctsh] and Mitogen activated protein kinase 1 [Mapk1] with Caspase 8 [Casp8]) with probabilities greater than 0.8 are consistent with the interactions in the biological pathway generated from curation of scientific literature (Figure 4).


Lectin Binding (binding) of in Langerhans cell associated with cancer
14) Confidence 0.30 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 0.34 Pain Relevance 0
Four gene-to-gene interactions (S100 Calpactin [S100a10] with annexin A2 [Anxa2], Lectin, galactose binding, soluble 3 [Lgals3] with Epidermal Langerhans cell protein [Lcp1], Tumor protein p53 [TP53] with Cathepsin H [Ctsh] and Mitogen activated protein kinase 1 [Mapk1] with Caspase 8 [Casp8]) with probabilities greater than 0.8 are consistent with the interactions in the biological pathway generated from curation of scientific literature (Figure 4).


Lectin Binding (interactions) of in Langerhans cell associated with cancer
15) Confidence 0.30 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 0.34 Pain Relevance 0
In the trigeminal tract the cytoplasm of many unmyelinated axons and a few small myelinated axons was found to bind this lectin.
lectin Binding (bind) of associated with unmyelinated
16) Confidence 0.29 Published 1993 Journal Neuroscience Section Abstract Doc Link 8450967 Disease Relevance 0.41 Pain Relevance 0.13
Retrogradely labelled neurones were then screened for lectin binding using a lectin-horseradish peroxidase conjugate.
lectin Binding (binding) of
17) Confidence 0.13 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8264961 Disease Relevance 0.08 Pain Relevance 0
In this study we have used a combination of lectin binding and retrograde tracing to examine the distribution of this glycoconjugate on sensory neurones which innervate different target tissues in the rat.
lectin Binding (binding) of
18) Confidence 0.12 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8264961 Disease Relevance 0.09 Pain Relevance 0
Concanavalin A -FITC lectin has proven to be a valuable tool because of its affinity for the pterygial surface, which allows detecting even small areas of pterygial tissue.
lectin Binding (affinity) of
19) Confidence 0.11 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2636009 Disease Relevance 0.56 Pain Relevance 0
Aims:
The purpose of this study was to determine whether concanavalin A (ConA) lectin bound to the pterygial surface can be used to detect recurrence or remnants of pterygium after surgical excision.


lectin Binding (bound) of associated with conjunctiva disease and recurrence
20) Confidence 0.11 Published 2007 Journal Indian Journal of Ophthalmology Section Abstract Doc Link PMC2636009 Disease Relevance 0.63 Pain Relevance 0

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