INT86946

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Context Info
Confidence 0.74
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 2.87
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 3
TRAP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 19 100.00 Very High Very High Very High
cerebral cortex 1 86.00 High High
anesthesia 1 71.76 Quite High
Potency 20 66.56 Quite High
Bioavailability 20 58.60 Quite High
imagery 8 56.64 Quite High
Pain 14 56.00 Quite High
antagonist 20 50.00 Quite Low
chemokine 2 39.68 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 464 89.16 High High
Stress 6 84.36 Quite High
Hypercalcemia 56 84.24 Quite High
Necrosis 18 69.80 Quite High
Spontaneous Fractures 16 68.84 Quite High
Gauchers Disease 60 64.40 Quite High
Pain 12 56.00 Quite High
Bone Cancer 4 51.72 Quite High
Multiple Myeloma 24 50.88 Quite High
Compression Fractures 6 38.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both acids significantly increased chemiluminescence and TBA-RS and decreased TRAP, indicating a simulation of lipid peroxidation and a reduction of tissue antioxidant potential.
Localization (decreased) of TRAP
1) Confidence 0.74 Published 2000 Journal Neuroreport Section Abstract Doc Link 10718311 Disease Relevance 0.16 Pain Relevance 0.11
For patients given full-dose ERT, platelet counts increased slightly faster, ferritin and TRAP decreased faster, but chitotriosidase and ACE declined more slowly.
Localization (decreased) of TRAP in platelet
2) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.23 Pain Relevance 0
Platelet counts in nonsplenectomized patients were stable before ERT (+190 platelets/year), while chitotriosidase and TRAP decreased slightly, and ferritin and ACE increased slightly.
Localization (decreased) of TRAP in Platelet
3) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.31 Pain Relevance 0.08
We used ion-exchange chromatography (IEC) to separate a complex protein mixture, proteins secreted by human platelets in response to the agonist thrombin receptor-activating peptide (TRAP), into fractions suitable for both biological analysis and identification by mass spectrometry.
Localization (secreted) of TRAP in platelets associated with agonist
4) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.05
The strong effects of PDM02, PDM10, and, to a lesser extent, PDM11 on OC differentiation were demonstrated in three different ways: (1) by inhibition of the formation of TRAP-positive multinucleated cells, (2) by inhibition of the release of TRAP in the medium, and (3) by downregulation of the expression of cathepsin K, all widely recognized hallmarks of OC differentiation.
Localization (release) of TRAP
5) Confidence 0.14 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.74 Pain Relevance 0.03
Supplementation of the culture media with either PDM10 or PDM11 reduced the levels of TRAP activity released into the culture media (Supplementary Fig. 1) and suppressed the expression of cathepsin K in a dose-dependent fashion.
Localization (released) of TRAP
6) Confidence 0.14 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.21 Pain Relevance 0
The strong effects of PDM02, PDM10, and, to a lesser extent, PDM11 on OC differentiation were demonstrated in three different ways: (1) by inhibition of the formation of TRAP-positive multinucleated cells, (2) by inhibition of the release of TRAP in the medium, and (3) by downregulation of the expression of cathepsin K, all widely recognized hallmarks of OC differentiation.
Localization (formation) of TRAP
7) Confidence 0.13 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.84 Pain Relevance 0.03
Note that TRAP slightly increased at the lower concentrations of PDM01, -02, and -10 (not of PDM06 and -11); but this increase was not significant.
Localization (increased) of TRAP
8) Confidence 0.13 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.38 Pain Relevance 0.03

General Comments

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