INT86950

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 18.92
Pain Relevance 12.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
T-cell 4
joints 2
blood 2
plasma 2
liver 2
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 133 100.00 Very High Very High Very High
Inflammation 124 100.00 Very High Very High Very High
antidepressant 8 99.98 Very High Very High Very High
spastic colon 4 99.84 Very High Very High Very High
nud 6 99.52 Very High Very High Very High
Clonidine 8 99.12 Very High Very High Very High
Arthritis 5 98.72 Very High Very High Very High
fluoxetine 18 97.88 Very High Very High Very High
Angina 22 97.04 Very High Very High Very High
narcan 5 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 160 100.00 Very High Very High Very High
Cancer 22 100.00 Very High Very High Very High
Necrosis 14 100.00 Very High Very High Very High
Repression 1 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 99.84 Very High Very High Very High
Dyspepsia 6 99.52 Very High Very High Very High
Ulcers 22 99.48 Very High Very High Very High
Experimental Arthritis 3 99.08 Very High Very High Very High
Myocardial Infarction 18 97.36 Very High Very High Very High
Cv General 3 Under Development 19 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-administration of NE and YHB, however, significantly attenuated IL-1beta and IL-10 production.
Negative_regulation (attenuated) of Gene_expression (production) of IL-10
1) Confidence 0.42 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949713 Disease Relevance 0.19 Pain Relevance 0.24
We found a significant increase of IFNgamma and TNFalpha production (P<0.01) and a significant decrease of IL10 production (P<0.05) in cultures of lymphomonocytes taken from patients with AMI and UA compared with SA patients and controls.
Negative_regulation (decrease) of Gene_expression (production) of IL10 associated with angina and myocardial infarction
2) Confidence 0.35 Published 2006 Journal Clin. Exp. Med. Section Abstract Doc Link 16550343 Disease Relevance 1.58 Pain Relevance 0.60
We found a significant increase of IFNgamma and TNFalpha production (p<0.01) and a significant decrease of IL-10 production (p<0.01) in cultures of lymphomonocytes taken from patients with AMI and UA compared with SA patients and controls.
Negative_regulation (decrease) of Gene_expression (production) of IL-10 associated with angina and myocardial infarction
3) Confidence 0.33 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 16216352 Disease Relevance 1.89 Pain Relevance 1.01
Our data showed an increased production of proinflammatory mediators in ACS that may be detectable both in circulating blood and in cell cultures where it is possible to evaluate in a better way the functional state of cells; this finding was associated with a reduced production of the antiinflammatory cytokine IL10.
Negative_regulation (reduced) of Gene_expression (production) of IL10 in blood associated with acute coronary syndrome, inflammation and cytokine
4) Confidence 0.31 Published 2006 Journal Clin. Exp. Med. Section Abstract Doc Link 16550343 Disease Relevance 1.07 Pain Relevance 0.41
In a pregnant rhesus monkey model, combined intra-amniotic and maternal systemic IL-10 administration inhibited IL-1?
Negative_regulation (inhibited) of Gene_expression (administration) of IL-10
5) Confidence 0.29 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 1.08 Pain Relevance 0.29
In contrast to ASA, the treatment with NO-ASA failed to influence both, the ulcer healing and GBF at ulcer margin and significantly attenuated the plasma levels of IL-1beta, TNF-alpha and IL-10 as compared to those recorded in ASA- or rofecoxib-treated animals.
Neg (failed) Negative_regulation (attenuated) of Gene_expression (levels) of IL-10 in plasma associated with ulcers
6) Confidence 0.29 Published 2004 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15613743 Disease Relevance 2.00 Pain Relevance 0.14
Both repeated and single administration of BLF suppressed TNF-alpha production and increased IL-10 production in the LPS-stimulated adjuvant arthritis rats.
Negative_regulation (suppressed) of Gene_expression (production) of IL-10 associated with experimental arthritis and arthritis
7) Confidence 0.28 Published 2004 Journal J. Vet. Med. Sci. Section Abstract Doc Link 15031542 Disease Relevance 1.17 Pain Relevance 0.98
Additionally, clonidine reduced the capacity of leukocytes to express pro-inflammatory cytokines as assessed by treatment of cells ex vivo with lipopolysaccharide, whereas no repression of IL-10 production occurred.
Neg (no) Negative_regulation (repression) of Gene_expression (production) of IL-10 in leukocytes associated with inflammation, repression, cytokine and clonidine
8) Confidence 0.27 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16192389 Disease Relevance 1.29 Pain Relevance 1.74
In addition, we found increased liver and serum TAG, along with reduced apoB protein expression and IL-6 and IL-10 levels in the of R in relation to the control and trained groups.


Negative_regulation (reduced) of Gene_expression (expression) of IL-10 in liver
9) Confidence 0.24 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2959201 Disease Relevance 0.55 Pain Relevance 0.19
However, Hawthorn extract was able to maintain IL-10 expression close to levels observed in sham (Figure 2), possibly by enhancing the presence or activity of regulatory T cells in the brain.
Negative_regulation (maintain) of Gene_expression (expression) of IL-10 in regulatory T cells
10) Confidence 0.24 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.36 Pain Relevance 0.08
There was a notable decrease in levels of IL-4 (63.8 ± 11.1 pg/mL vs. 105.9 ± 24.2 pg/mL) and IL-10 (462.4 ± 31.2 pg/mL vs. 979.5 ± 150.3 pg/mL).
Negative_regulation (decrease) of Gene_expression (levels) of IL-10
11) Confidence 0.20 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004822 Disease Relevance 0.49 Pain Relevance 0.14
RESULTS: Placental production of IL-10 was not affected by clonidine, but decreased significantly after incubation of the tissue with diazoxide, hydralazine or furosemide.
Neg (not) Negative_regulation (decreased) of Gene_expression (production) of IL-10
12) Confidence 0.16 Published 2006 Journal J. Hypertens. Section Body Doc Link 16612254 Disease Relevance 0.06 Pain Relevance 0
RESULTS: The level of TNF-alpha was increased and the levels of IL-2 and IL-10 in the serum were decreased in both groups after extracorporeal circulation for 2 h and 24 h, and the ranges of all changes were more less in group A (all P < 0.05).
Negative_regulation (decreased) of Gene_expression (levels) of IL-10
13) Confidence 0.16 Published 2010 Journal Zhongguo Zhen Jiu Section Body Doc Link 20862944 Disease Relevance 0 Pain Relevance 0
Furthermore, thalidomide pretreatment significantly reduced the concentration of tumor necrosis factor-alpha (TNF-alpha, -68.4%) in the exudate of zymosan-injected joints, but not those of interleukin-1beta, interleukin-6, CINC-1 or interleukin-10.
Negative_regulation (reduced) of Gene_expression (concentration) of interleukin-10 in joints associated with necrosis and cancer
14) Confidence 0.15 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16597438 Disease Relevance 0.68 Pain Relevance 0.19
Conversely, synthesis of the anti-inflammatory cytokine interleukin 10 (IL-10) decreased significantly in LPS-stimulated cultures.
Negative_regulation (decreased) of Gene_expression (synthesis) of anti-inflammatory cytokine interleukin 10 associated with inflammation and cytokine
15) Confidence 0.13 Published 2003 Journal Shock Section Abstract Doc Link 12923491 Disease Relevance 0.35 Pain Relevance 0.93
Conversely, synthesis of the anti-inflammatory cytokine interleukin 10 (IL-10) decreased significantly in LPS-stimulated cultures.
Negative_regulation (decreased) of Gene_expression (synthesis) of IL-10 associated with inflammation and cytokine
16) Confidence 0.11 Published 2003 Journal Shock Section Abstract Doc Link 12923491 Disease Relevance 0.35 Pain Relevance 0.93
In sepsis patients, IL-2, IL-5, and IL-10 productions by isolated PBMC were diminished on ConA-induced activation but not in response to PHA and anti-CD3; in CPB patients, only anti-CD3-induced IL-10 production was significantly reduced.
Negative_regulation (reduced) of Gene_expression (production) of IL-10 in PBMC associated with sepsis
17) Confidence 0.08 Published 2000 Journal Shock Section Abstract Doc Link 10718372 Disease Relevance 0.42 Pain Relevance 0.16
However, the decrease in IL-10 production due to indomethacin suggests a more inflammatory state.
Negative_regulation (decrease) of Gene_expression (production) of IL-10 associated with inflammation
18) Confidence 0.07 Published 2000 Journal Exp. Gerontol. Section Abstract Doc Link 11121687 Disease Relevance 0.41 Pain Relevance 0.46
Indomethacin reduced the production of LPS-induced IL-6, IL-1 beta and IL-10 (p<0.05) at the highest indomethacin concentration tested.
Negative_regulation (reduced) of Gene_expression (production) of IL-10
19) Confidence 0.07 Published 2000 Journal Exp. Gerontol. Section Abstract Doc Link 11121687 Disease Relevance 0.52 Pain Relevance 0.54
We propose that decreased levels of IL-10 after treatment with anti-CTLA-4 therapy may be responsible for irAEs in some patients and needs to be further investigated in larger studies.
Negative_regulation (decreased) of Gene_expression (levels) of IL-10
20) Confidence 0.07 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18503261 Disease Relevance 0.46 Pain Relevance 0.29

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