INT86971

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Context Info
Confidence 0.15
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 0.08
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE1B) signal transduction (PDE1B) nucleolus (PDE1B)
nucleus (PDE1B) cytoplasm (PDE1B)
Anatomy Link Frequency
smooth muscles 1
brain 1
lungs 1
heart 1
PDE1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 3 95.96 Very High Very High Very High
agonist 4 80.92 Quite High
Dopamine 1 80.48 Quite High
Clonidine 2 77.32 Quite High
Neurotransmitter 42 72.52 Quite High
adenocard 9 7.16 Low Low
long-term potentiation 265 5.00 Very Low Very Low Very Low
Inflammation 76 5.00 Very Low Very Low Very Low
Hippocampus 45 5.00 Very Low Very Low Very Low
depression 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 81.28 Quite High
Cognitive Disorder 470 50.00 Quite Low
INFLAMMATION 88 5.00 Very Low Very Low Very Low
Targeted Disruption 79 5.00 Very Low Very Low Very Low
Pulmonary Disease 62 5.00 Very Low Very Low Very Low
Anxiety Disorder 60 5.00 Very Low Very Low Very Low
Disease 47 5.00 Very Low Very Low Very Low
Depression 40 5.00 Very Low Very Low Very Low
Schizophrenia 30 5.00 Very Low Very Low Very Low
Aging 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The spatial location of PDEs within cells is now also known to be important in determining their intracellular effects and this appears to be determined to some extent by the presence of different targeting domains in the N-terminal domain.
Localization (location) of PDEs
1) Confidence 0.15 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.08 Pain Relevance 0
The N-terminal domain shows great diversity between PDE families (Figure 1) and understanding the functional relevance of the differences in the N-terminal domains is crucial to understanding the regulation and sub-cellular localization of different PDEs and to the development of drugs that modulate PDE activity.
Localization (localization) of PDEs
2) Confidence 0.14 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
Localization of PDEs
Localization (Localization) of PDEs
3) Confidence 0.05 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.04
PDE1 is predominantly localized in the brain, heart, smooth muscles, and lungs (Dent et al. 1998; Sonnenburg et al. 1998; Yan et al. 1994).
Localization (localized) of PDE1 in smooth muscles
4) Confidence 0.05 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.04
PDE1 is predominantly localized in the brain, heart, smooth muscles, and lungs (Dent et al. 1998; Sonnenburg et al. 1998; Yan et al. 1994).
Localization (localized) of PDE1 in brain
5) Confidence 0.02 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.04
PDE1 is predominantly localized in the brain, heart, smooth muscles, and lungs (Dent et al. 1998; Sonnenburg et al. 1998; Yan et al. 1994).
Localization (localized) of PDE1 in heart
6) Confidence 0.02 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.04
PDE1 is predominantly localized in the brain, heart, smooth muscles, and lungs (Dent et al. 1998; Sonnenburg et al. 1998; Yan et al. 1994).
Localization (localized) of PDE1 in lungs
7) Confidence 0.02 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.04
In goldfish, D1-stimulated GH release is mediated by AC-, arachidonic acid-and Ca2+-dependent pathways, whereas GnRH action is coupled to PKC-and Ca2+-dependent mechanisms.
Localization (release) of D1-stimulated associated with kinase c
8) Confidence 0.00 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10718929 Disease Relevance 0 Pain Relevance 0.42

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