INT8698

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 50
Total Number 52
Disease Relevance 5.80
Pain Relevance 27.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
stomach 3
colon 3
spinal cord 3
nerve 3
blood 2
Nka1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 288 100.00 Very High Very High Very High
Calcitonin gene-related peptide 92 100.00 Very High Very High Very High
Neuropeptide 45 100.00 Very High Very High Very High
Inflammation 9 100.00 Very High Very High Very High
qutenza 224 99.82 Very High Very High Very High
primary afferent fibers 8 99.76 Very High Very High Very High
Spinal cord 46 99.34 Very High Very High Very High
antagonist 39 99.24 Very High Very High Very High
lidocaine 6 99.20 Very High Very High Very High
agonist 49 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 99.44 Very High Very High Very High
Pressure Volume 2 Under Development 38 99.22 Very High Very High Very High
Heart Rate Under Development 98 98.98 Very High Very High Very High
Pain 22 98.48 Very High Very High Very High
Cough 7 97.32 Very High Very High Very High
Increased Venous Pressure Under Development 32 96.08 Very High Very High Very High
Cv Unclassified Under Development 14 93.56 High High
Ganglion Cysts 5 93.44 High High
Targeted Disruption 6 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The release of calcitonin gene-related peptide (CGRP), neurokinin A (NKA) and substance P (SP) from intralumenally perfused rat trachea was examined in vitro.
Spec (examined) Localization (release) of NKA in trachea associated with substance p and calcitonin gene-related peptide
1) Confidence 0.78 Published 1992 Journal Peptides Section Abstract Doc Link 1377821 Disease Relevance 0 Pain Relevance 0.64
Continuous electric stimulation of the pelvic nerve in cats at 4 Hz during 1 s with 10 s rest produced a marked release of NKA-LI and SP-LI from the colon to blood.
Localization (release) of NKA in colon associated with substance p
2) Confidence 0.78 Published 1991 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 1950787 Disease Relevance 0.14 Pain Relevance 0.37
Reflex activation of the pelvic nervae by mechanical stimulation of the anus or rectal distension produced a less pronounced release of NKA-LI and SP-LI from the colon to blood.
Localization (release) of NKA in colon associated with substance p
3) Confidence 0.78 Published 1991 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 1950787 Disease Relevance 0.17 Pain Relevance 0.38
The amounts of SP-LI and NKA-LI released by potassium in vitro were 1.02 +/- 0.12 and 1.17 +/- 0.22 fmol/mg tissue, respectively.
Localization (released) of NKA associated with substance p
4) Confidence 0.76 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.54
Despite the use of highly sensitive radioimmunoassays, basal release of SP-LI and NKA-LI was found only in 9 of 31 in vivo experiments.
Localization (release) of NKA associated with substance p
5) Confidence 0.76 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.64
Stimulation with pulses of 40 mM potassium or 10 microM capsaicin in the spinal cord superfusion fluid increased the release of substance P (SP)- and neurokinin A (NKA)-like immunoreactivity (LI) both in vivo and in vitro.
Localization (release) of NKA in spinal cord associated with qutenza, substance p and spinal cord
6) Confidence 0.76 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.51
The present findings provide neurochemical evidence that both NKA-LI and CGRP-LI are released from different regions of the rat stomach and both peptides should therefore be taken into account when considering the efferent function of capsaicin-sensitive primary afferents at gastric level.
Localization (released) of NKA in stomach associated with qutenza and calcitonin gene-related peptide
7) Confidence 0.71 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1716741 Disease Relevance 0 Pain Relevance 1.30
In the gastric corpus, the capsaicin-induced NKA-LI and CGRP-LI release was larger from the muscle layer than from the mucosa.
Localization (release) of NKA in gastric corpus associated with qutenza and calcitonin gene-related peptide
8) Confidence 0.71 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1716741 Disease Relevance 0 Pain Relevance 1.40
Both in the gastric fundus and in the corpus, capsaicin (10 microM) produced a remarkable release of of CGRP-LI and NKA-LI, but not of SP-LI.
Localization (release) of NKA in corpus associated with qutenza, substance p and calcitonin gene-related peptide
9) Confidence 0.71 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1716741 Disease Relevance 0 Pain Relevance 1.45
In this study, it was examined whether capsaicin might induce the release of neurokinin A (NKA), substance P (SP) and calcitonin gene-related peptide (CGRP) from different regions of rat stomach.
Localization (release) of NKA in stomach associated with qutenza, calcitonin gene-related peptide and substance p
10) Confidence 0.71 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1716741 Disease Relevance 0 Pain Relevance 1.03
NKA-LI, SP-LI and CGRP-LI release induced by capsaicin was measured in different regions of the rat stomach.
Localization (release) of NKA in stomach associated with qutenza, calcitonin gene-related peptide and substance p
11) Confidence 0.71 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1716741 Disease Relevance 0 Pain Relevance 1.42
Similarly, NKA partially inhibited the VIP-stimulated bicarbonate secretion.
Localization (secretion) of NKA
12) Confidence 0.71 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9655689 Disease Relevance 0 Pain Relevance 0.27
Elevation of intraluminal pressure, however, potentiated the stimulatory effect of NKA on bicarbonate secretion.
Localization (secretion) of NKA
13) Confidence 0.70 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9655689 Disease Relevance 0 Pain Relevance 0.25
Superfusion of slices of the dorsal half of rat spinal cord in vitro with 10 microM capsaicin or 60 mM potassium lead to the simultaneous release of substance P (SP)-, neurokinin A (NKA)- and calcitonin gene-related peptide (CGRP)-like immunoreactivities (LI).
Localization (release) of NKA in dorsal associated with qutenza, calcitonin gene-related peptide, substance p and spinal cord
14) Confidence 0.68 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 2419807 Disease Relevance 0 Pain Relevance 0.74
Reversed-phase high performance liquid chromatography of the NKA-LI released in vitro by potassium or capsaicin revealed a major immunoreactive component coeluting with synthetic NKA.
Localization (released) of NKA associated with qutenza
15) Confidence 0.67 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.62
The results obtained in vitro suggest that SP and NKA are released in equimolar amounts from the spinal cord upon stimulation with potassium.
Localization (released) of NKA in spinal cord associated with spinal cord and substance p
16) Confidence 0.66 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.44
Mannitol, at the same osmolarity as HS 3.6%, did not elicit a change in airway resistance, CRGP or NKA release.
Localization (release) of NKA
17) Confidence 0.65 Published 1999 Journal Eur. J. Clin. Invest. Section Body Doc Link 10202384 Disease Relevance 0.06 Pain Relevance 0
This was associated with release of calcitonin gene-related peptide (CGRP) 7.7 +/- 1.9 fmol mL-1 g (P < 0.01), but not of neurokinin A (NKA), a known bronchoconstrictor.
Localization (release) of NKA
18) Confidence 0.65 Published 1999 Journal Eur. J. Clin. Invest. Section Body Doc Link 10202384 Disease Relevance 0.07 Pain Relevance 0
Reflex activation of the pelvic nerve by mechanical stimulation of the anus or rectal distension produced a less pronounced release of NKA-LI and SP-LI from the colon to blood (P less than 0.01).
Localization (release) of NKA in anus associated with substance p
19) Confidence 0.63 Published 1991 Journal Gastroenterology Section Abstract Doc Link 1702076 Disease Relevance 0.09 Pain Relevance 0.31
The airway constriction induced by capsaicin is thought to be mediated by the release of SP and NKA from sensory nerve endings, and the persistent increase in airway resistance induced by capsaicin is thought to be due mainly to NKA.
Localization (release) of NKA in sensory nerve associated with qutenza and substance p
20) Confidence 0.61 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1711981 Disease Relevance 0.16 Pain Relevance 0.57

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