INT86982

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.98
Pain Relevance 5.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
trigeminal ganglion 1
dorsomedial hypothalamic nucleus 1
lateral 1
lateral hypothalamic area 1
preoptic area 1
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 47 100.00 Very High Very High Very High
calcitonin gene related peptide 11 100.00 Very High Very High Very High
Neuropeptide 9 100.00 Very High Very High Very High
substance P 3 99.80 Very High Very High Very High
qutenza 12 99.72 Very High Very High Very High
Trigeminal ganglion neurons 1 99.56 Very High Very High Very High
Raphe 8 98.12 Very High Very High Very High
Pain 6 96.32 Very High Very High Very High
Hippocampus 4 95.44 Very High Very High Very High
Central grey 4 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 89 99.40 Very High Very High Very High
Targeted Disruption 48 97.00 Very High Very High Very High
Pain 7 96.32 Very High Very High Very High
Urological Neuroanatomy 4 95.32 Very High Very High Very High
Cognitive Disorder 4 93.16 High High
Neurodegenerative Disease 6 87.64 High High
Headache 2 85.52 High High
Wound Healing 10 77.60 Quite High
Cluster Headache 1 75.44 Quite High
Injury 8 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide produced by tissue-specific alternative splicing of the primary transcript of the calcitonin/CGRP gene.
Transcription (transcript) of CGRP associated with neuropeptide and calcitonin gene-related peptide
1) Confidence 0.69 Published 2008 Journal Biomed. Pharmacother. Section Abstract Doc Link 18430544 Disease Relevance 0.43 Pain Relevance 0.49
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide produced by tissue-specific alternative splicing of the primary transcript of the calcitonin/CGRP gene.
Transcription (transcript) of calcitonin associated with neuropeptide and calcitonin gene-related peptide
2) Confidence 0.69 Published 2008 Journal Biomed. Pharmacother. Section Abstract Doc Link 18430544 Disease Relevance 0.43 Pain Relevance 0.48
Calcitonin receptor mRNA was expressed in various brain regions, including the preoptic area, dorsomedial hypothalamic nucleus, lateral hypothalamic area, periaqueductal gray, dorsal raphe nucleus, locus coeruleus, lateral parabrachial nucleus, gigantocellular reticular nucleus alpha part, lateral paragigantocellular nucleus, raphe magnus nucleus and solitary tract nucleus, which are known to play important roles in pain modulation.
Transcription (expressed) of Calcitonin in lateral hypothalamic area associated with pain, raphe magnus, locus ceruleus, raphe, central grey and parabrachial
3) Confidence 0.53 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10719219 Disease Relevance 0.18 Pain Relevance 0.48
In addition, a double in situ hybridization technique demonstrated the intense expression of calcitonin receptor mRNA on serotonergic neurons in some raphe nuclei and the lateral paragigantocellular nucleus, suggesting the involvement of central serotonergic pathways in analgesic effect of calcitonin.
Transcription (expression) of calcitonin in lateral associated with analgesic and raphe
4) Confidence 0.53 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10719219 Disease Relevance 0.18 Pain Relevance 0.57
We first demonstrated that activation of CGRP receptors on cultured trigeminal ganglion neurons increased endogenous CGRP mRNA levels and promoter activity.
Transcription (levels) of CGRP in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion neurons and calcitonin gene-related peptide
5) Confidence 0.45 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344407 Disease Relevance 0.42 Pain Relevance 0.61
Significant increases of the hippocampal tissue levels of CGRP, IGF-I, and IGF-I messenger RNA (mRNA) were observed after capsaicin administration in WT mice (P < 0.01) but not in CGRP-/- mice.
Transcription (observed) of CGRP associated with qutenza and calcitonin gene-related peptide
6) Confidence 0.23 Published 2009 Journal Transl Res Section Abstract Doc Link 19595440 Disease Relevance 0.51 Pain Relevance 1.09
In contrast, expression levels of mRNA for the Runx1-independent neuropeptides CGRP and Substance P/Tachykinin 1 (SP/Tac1) were little changed (Figure 3B), consistent with past results [16,17].
Transcription (levels) of CGRP associated with calcitonin gene related peptide, neuropeptide and substance p
7) Confidence 0.22 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 1.07
Calcitonin receptor mRNA was expressed in various brain regions, including the preoptic area, dorsomedial hypothalamic nucleus, lateral hypothalamic area, periaqueductal gray, dorsal raphe nucleus, locus coeruleus, lateral parabrachial nucleus, gigantocellular reticular nucleus alpha part, lateral paragigantocellular nucleus, raphe magnus nucleus and solitary tract nucleus, which are known to play important roles in pain modulation.
Transcription (expressed) of Calcitonin in preoptic area associated with pain, raphe magnus, locus ceruleus, raphe, central grey and parabrachial
8) Confidence 0.18 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10719219 Disease Relevance 0.18 Pain Relevance 0.48
Calcitonin receptor mRNA was expressed in various brain regions, including the preoptic area, dorsomedial hypothalamic nucleus, lateral hypothalamic area, periaqueductal gray, dorsal raphe nucleus, locus coeruleus, lateral parabrachial nucleus, gigantocellular reticular nucleus alpha part, lateral paragigantocellular nucleus, raphe magnus nucleus and solitary tract nucleus, which are known to play important roles in pain modulation.
Transcription (expressed) of Calcitonin in dorsomedial hypothalamic nucleus associated with pain, raphe magnus, locus ceruleus, raphe, central grey and parabrachial
9) Confidence 0.18 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10719219 Disease Relevance 0.18 Pain Relevance 0.48

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