INT8699

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2010
Negated 5
Speculated 3
Reported most in Abstract
Documents 45
Total Number 48
Disease Relevance 6.41
Pain Relevance 22.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
teeth 4
nerve 4
nervous system 2
spinal cord 2
colon 2
Nka1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 395 100.00 Very High Very High Very High
Calcitonin gene-related peptide 66 100.00 Very High Very High Very High
Neuropeptide 35 100.00 Very High Very High Very High
Spinal cord 30 100.00 Very High Very High Very High
Dorsal horn 18 100.00 Very High Very High Very High
agonist 51 99.98 Very High Very High Very High
Intracerebroventricular 2 99.98 Very High Very High Very High
Central nervous system 5 99.88 Very High Very High Very High
qutenza 74 99.84 Very High Very High Very High
antagonist 85 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 99.98 Very High Very High Very High
Wheal 9 99.56 Very High Very High Very High
Dysmenorrhea 2 99.00 Very High Very High Very High
Headache 16 98.92 Very High Very High Very High
Bronchospasm 1 98.88 Very High Very High Very High
Nociception 27 98.80 Very High Very High Very High
Epilepsy 10 98.52 Very High Very High Very High
Erythema 3 98.08 Very High Very High Very High
Parkinson's Disease 1 98.00 Very High Very High Very High
Pain 25 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurokinin A (NKA), substance P (SP) and the two peptides combined (SP + NKA) were injected intracutaneously on the forearm and into the temporal muscle of healthy volunteers.
Gene_expression (injected) of NKA in muscle associated with substance p
1) Confidence 0.67 Published 1989 Journal Peptides Section Abstract Doc Link 2482964 Disease Relevance 0.44 Pain Relevance 0.60
In these, peripheral electrical stimulation of the sciatic nerves (50 Hz, 50 V and 0.05 ms or 10 Hz, 10 V and 5 ms) induced an increase of the SP-LI and NKA-LI levels in the superfusates.
Gene_expression (levels) of NKA in sciatic nerves associated with sciatic nerve and substance p
2) Confidence 0.64 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.68
[beta Ala8]Neurokinin A-(4-10) was as active as, or more active than, neurokinin A (NKA) or NKA-(4-10) in producing rat bladder contraction or bronchospasm in guinea-pigs, two effects known to involve activation of NK-2 receptors.
Gene_expression (producing) of NKA in bladder associated with bronchospasm
3) Confidence 0.63 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2160369 Disease Relevance 0.18 Pain Relevance 0.11
A large depletion (about 80%) of CGRP-LI following capsaicin treatment was observed in all regions examined, while no difference was observed for NKA-LI and SP-LI.
Neg (no) Gene_expression (observed) of NKA associated with qutenza, substance p and calcitonin gene-related peptide
4) Confidence 0.60 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1716741 Disease Relevance 0 Pain Relevance 1.41
In accord with the relative tissue levels of the respective peptides, capsaicin (10(-8) to 10(-5) M) and K+ (120 mM) added to the perfusate resulted in a concentration-dependent increase in the levels of CGRP and NKA, and to a minor extent SP, in the perfusates.
Gene_expression (levels) of NKA associated with qutenza, substance p and calcitonin gene-related peptide
5) Confidence 0.58 Published 1992 Journal Peptides Section Abstract Doc Link 1377821 Disease Relevance 0 Pain Relevance 0.94
Reflex activation of the pelvic nervae by mechanical stimulation of the anus or rectal distension produced a less pronounced release of NKA-LI and SP-LI from the colon to blood.
Gene_expression (produced) of NKA in colon associated with substance p
6) Confidence 0.58 Published 1991 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 1950787 Disease Relevance 0.17 Pain Relevance 0.39
Continuous electric stimulation of the pelvic nerve in cats at 4 Hz during 1 s with 10 s rest produced a marked release of NKA-LI and SP-LI from the colon to blood.
Gene_expression (produced) of NKA in colon associated with substance p
7) Confidence 0.58 Published 1991 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 1950787 Disease Relevance 0.14 Pain Relevance 0.37
In most experiments, however, no SP-LI or NKA-LI could be detected in the superfusates, neither at basal conditions nor following electrical nerve stimulation.
Neg (neither) Gene_expression (detected) of NKA in nerve associated with substance p
8) Confidence 0.57 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.67
Intracerebroventricular injection of NPK, NKA, and NP gamma as well as SP, which was ineffective in intact male rats, evoked a long-lasting suppression of LH release.
Gene_expression (injection) of NKA associated with intracerebroventricular and substance p
9) Confidence 0.56 Published 1992 Journal Endocrinology Section Abstract Doc Link 1380435 Disease Relevance 0 Pain Relevance 0.54
The catalytic subunit of NKA exists in different forms and mutations in two of the forms that are expressed in brain can give rise to migraine, epilepsy and Parkinsonism-like symptoms.
Gene_expression (expressed) of NKA in brain associated with parkinson's disease, epilepsy and migraine
10) Confidence 0.52 Published 2007 Journal J. Intern. Med. Section Abstract Doc Link 17222167 Disease Relevance 0.48 Pain Relevance 0.10
RESULTS: The levels of NKA in human eye tissues were approximately 10 times higher than those of SP but lower than those of CGRP.
Gene_expression (levels) of NKA in eye
11) Confidence 0.51 Published 2005 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 15623783 Disease Relevance 0 Pain Relevance 0
Reverse-phase high performance liquid chromatography showed presence of NKA, NKA oxide, NKA (3-10)/NKA (4-10), and neuropeptide K (NPK) in colonic tissues and release of all these molecular forms except NPK on nerve stimulation.
Gene_expression (presence) of NKA in nerve associated with neuropeptide
12) Confidence 0.47 Published 1991 Journal Gastroenterology Section Abstract Doc Link 1702076 Disease Relevance 0.16 Pain Relevance 0.38
It is concluded that SP and NKA are present in significantly greater amounts in the GCF of painful teeth compared with healthy teeth.
Gene_expression (present) of NKA in teeth associated with pain and substance p
13) Confidence 0.46 Published 2002 Journal Eur. J. Oral Sci. Section Abstract Doc Link 12120702 Disease Relevance 0.07 Pain Relevance 1.25
Reverse-phase high performance liquid chromatography showed presence of NKA, NKA oxide, NKA (3-10)/NKA (4-10), and neuropeptide K (NPK) in colonic tissues and release of all these molecular forms except NPK on nerve stimulation.
Gene_expression (presence) of NKA in nerve associated with neuropeptide
14) Confidence 0.41 Published 1991 Journal Gastroenterology Section Abstract Doc Link 1702076 Disease Relevance 0.16 Pain Relevance 0.39
A mammalian tachykinin, neurokinin A (NKA), and its analogs produced concentration-dependent contractions in the isolated rabbit iris sphincter muscle.
Gene_expression (produced) of NKA in muscle
15) Confidence 0.41 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2430095 Disease Relevance 0 Pain Relevance 0.33
The aim of this study was to investigate the presence of substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) in the gingival crevicular fluid of teeth diagnosed with pain of pulpal origin compared with clinically healthy teeth, and to detect any changes in the levels of these neuropeptides in gingival crevicular fluid after removal of the pulp from the painful teeth.
Spec (investigate) Gene_expression (presence) of NKA in teeth associated with pain, neuropeptide, calcitonin gene-related peptide and substance p
16) Confidence 0.41 Published 2002 Journal Eur. J. Oral Sci. Section Abstract Doc Link 12120702 Disease Relevance 0.10 Pain Relevance 0.80
At the same time, the plasma levels of calcitonin gene-related peptide (CGRP), neurokinin A (NKA), prostaglandin E2 (PGE2) and 6 keto PGF1alpha, the stable product of PGI2, were assessed with radioimmunoassay (RIA) kits in the same samples.
Gene_expression (levels) of NKA in PGE2 associated with calcitonin gene-related peptide
17) Confidence 0.39 Published 2000 Journal Cephalalgia Section Abstract Doc Link 11304026 Disease Relevance 0.39 Pain Relevance 0.61
In contralateral teeth, there were no significant differences in the levels of SP and NKA after 1 wk.
Gene_expression (levels) of NKA in teeth associated with substance p
18) Confidence 0.35 Published 2002 Journal Eur. J. Oral Sci. Section Abstract Doc Link 12120702 Disease Relevance 0.07 Pain Relevance 1.27
In the presence of the peptidase inhibitors (thiorphan, captopril and bestatin), the mammalian tachykinins SP, NKA and NKB produced concentration-dependent uterine contractions. 5.
Gene_expression (produced) of NKA in uterine associated with dismenorea and substance p
19) Confidence 0.28 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11071311 Disease Relevance 0.19 Pain Relevance 0.48
Specific questions in this study were (1) does NKA also generate NO, (2) does NO counteract NKA-induced bronchoconstriction, and (3) does the NO generation require bronchial epithelial cells?
Gene_expression (generate) of NKA in epithelial cells
20) Confidence 0.26 Published 2001 Journal Nitric Oxide Section Abstract Doc Link 11587561 Disease Relevance 0 Pain Relevance 0.12

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