INT86998

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2010
Negated 7
Speculated 3
Reported most in Body
Documents 49
Total Number 52
Disease Relevance 37.83
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HIVEP1) intracellular (HIVEP1) DNA binding (HIVEP1)
cytoplasm (HIVEP1)
Anatomy Link Frequency
plasma 4
T cell 3
macrophages 2
CSF 1
gut 1
HIVEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 363 100.00 Very High Very High Very High
intrathecal 46 100.00 Very High Very High Very High
Opioid 7 99.98 Very High Very High Very High
addiction 27 99.70 Very High Very High Very High
methadone 42 98.56 Very High Very High Very High
Inflammation 99 98.28 Very High Very High Very High
cytokine 146 97.76 Very High Very High Very High
Pain 72 96.76 Very High Very High Very High
opiate 5 95.36 Very High Very High Very High
Leflunomide 54 95.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 3888 100.00 Very High Very High Very High
Infection 1388 100.00 Very High Very High Very High
Disease 260 100.00 Very High Very High Very High
Neuropathy 8 100.00 Very High Very High Very High
Cold Sores 290 99.86 Very High Very High Very High
Opiate Addiction 4 99.70 Very High Very High Very High
Sprains And Strains 130 98.86 Very High Very High Very High
Disease Progression 65 98.40 Very High Very High Very High
INFLAMMATION 117 98.28 Very High Very High Very High
Pain 61 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(462 bp) flanking regions of the GAAP gene, using oligonucleotides ?
Regulation (regions) of GAAP
1) Confidence 0.44 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0 Pain Relevance 0
Controlling HIV infection in women and children is crucial for changing the trajectory of the global HIV epidemic.
Regulation (Controlling) of HIV associated with acquired immune deficiency syndrome or hiv infection and infection
2) Confidence 0.39 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2365974 Disease Relevance 1.05 Pain Relevance 0
With this in mind, we set out to conduct this study in rural India, where we aimed to evaluate the impact of introducing rapid HIV testing in the labor room setting.
Regulation (introducing) of HIV associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.39 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2365974 Disease Relevance 0.87 Pain Relevance 0
Immunofluorescence analysis showed that 36 h post transfection, GAAP siRNA1 down-regulated h-GAAP and v-GAAP, whereas siRNAs 2 and 3 did not affect v-GAAP expression, and siRNA2 affected neither h-GAAP nor v-GAAP (Figure 7A).
Regulation (regulated) of v-GAAP
4) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.07 Pain Relevance 0
To study the role of the viral protein, a set of VACV strain Evans viruses (v-GAAP WT) were constructed in which the v-GAAP gene was deleted (v-?
Regulation (deleted) of v-GAAP associated with sprains and strains
5) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.36 Pain Relevance 0
Immunofluorescence analysis showed that 36 h post transfection, GAAP siRNA1 down-regulated h-GAAP and v-GAAP, whereas siRNAs 2 and 3 did not affect v-GAAP expression, and siRNA2 affected neither h-GAAP nor v-GAAP (Figure 7A).
Regulation (regulated) of h-GAAP
6) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.07 Pain Relevance 0
RT-PCR showed that GAAP siRNAs 1 and 3 down-regulated h-GAAP mRNA substantially by 36 h post transfection, whereas GAAP siRNA2 and a control siRNA against GFP did not (Figure 4A).
Regulation (regulated) of h-GAAP
7) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.16 Pain Relevance 0
To control for variations in HIV-1 shedding throughout the menstrual cycle subjects' study visits were conducted during the luteal phase of their cycle [22].
Regulation (control) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2741601 Disease Relevance 0.56 Pain Relevance 0
Accordingly, we tested GAAP siRNAs 1–3 for their ability to down-regulate v-GAAP in the U2OS human cell line that we had engineered to stably express v-GAAP, U2OS-v-GAAP.
Regulation (regulate) of v-GAAP
9) Confidence 0.23 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.08 Pain Relevance 0
Immunofluorescence analysis showed that 36 h post transfection, GAAP siRNA1 down-regulated h-GAAP and v-GAAP, whereas siRNAs 2 and 3 did not affect v-GAAP expression, and siRNA2 affected neither h-GAAP nor v-GAAP (Figure 7A).
Neg (neither) Regulation (affected) of v-GAAP
10) Confidence 0.23 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.07 Pain Relevance 0
Immunofluorescence analysis showed that 36 h post transfection, GAAP siRNA1 down-regulated h-GAAP and v-GAAP, whereas siRNAs 2 and 3 did not affect v-GAAP expression, and siRNA2 affected neither h-GAAP nor v-GAAP (Figure 7A).
Neg (neither) Regulation (affected) of h-GAAP
11) Confidence 0.23 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.07 Pain Relevance 0
The evolution of the HIV-1 RNA levels was the same during the follow-up of mean 186 months in a few of the patients in each of the two groups.
Regulation (evolution) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.11 Published 2001 Journal Eur J Pain Section Abstract Doc Link 11743707 Disease Relevance 0.61 Pain Relevance 0.94
Mean baseline HIV-1RNA values were 4.6–4.8 log10 copies/mL across all groups.
Regulation (values) of HIV associated with acquired immune deficiency syndrome or hiv infection
13) Confidence 0.08 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504063 Disease Relevance 0.47 Pain Relevance 0
Additional efficacy endpoints included percentage of patients with HIV RNA <50 copies/mL as well as change from baseline in HIV-1 RNA levels and CD4 cell counts.
Regulation (change) of HIV associated with acquired immune deficiency syndrome or hiv infection
14) Confidence 0.08 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504063 Disease Relevance 0.50 Pain Relevance 0
Significant improvements in neuropsychological functioning after initiating antiretroviral therapy were determined after controlling for baseline function, age, sex, country, CD4, plasma HIV-1 RNA stratum, and years of education.
Spec (determined) Regulation (controlling) of HIV-1 in plasma associated with acquired immune deficiency syndrome or hiv infection
15) Confidence 0.06 Published 2009 Journal Neuropsychol Rev Section Body Doc Link PMC2690834 Disease Relevance 0.60 Pain Relevance 0
HIV-SN is a distal symmetrical axonal, predominantly sensory polyneuropathy that affects the feet and less frequently the hands.
Regulation (affects) of HIV-SN associated with neuropathy and acquired immune deficiency syndrome or hiv infection
16) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3010990 Disease Relevance 1.98 Pain Relevance 0.22
In contrast, a long RNA antisense sequence targeting the HIV-1 envelope gene provided very strong inhibition of viral replication, but transduced cells did not exhibit a strong survival advantage in vitro.
Regulation (targeting) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
17) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 1.01 Pain Relevance 0.04
As seen in Figure 4A, GFP+ cells expressing maC46 sequestered HIV-1 p24 antigen (red) on the cell surface but did not contain any intracellular viral antigen.
Neg (not) Regulation (sequestered) of HIV-1 associated with acquired immune deficiency syndrome or hiv infection
18) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.72 Pain Relevance 0
Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial

Background

Regulation (effect) of HIV-1-infected associated with acquired immune deficiency syndrome or hiv infection
19) Confidence 0.05 Published 2009 Journal Trials Section Title Doc Link PMC2705367 Disease Relevance 0.49 Pain Relevance 0
Summary of important monocytic regulatory pathways regulating the HIV-1 LTR
Regulation (regulating) of HIV associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.04 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.85 Pain Relevance 0.17

General Comments

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