INT8700

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Context Info
Confidence 0.67
First Reported 1988
Last Reported 2010
Negated 5
Speculated 7
Reported most in Abstract
Documents 56
Total Number 63
Disease Relevance 21.69
Pain Relevance 53.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
neurons 10
plasma 8
outflow 6
blood 6
spinal 4
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 565 100.00 Very High Very High Very High
qutenza 238 100.00 Very High Very High Very High
Pain 74 100.00 Very High Very High Very High
Inflammation 56 100.00 Very High Very High Very High
substance P 53 100.00 Very High Very High Very High
Opioid 33 100.00 Very High Very High Very High
bradykinin 24 100.00 Very High Very High Very High
Spinal cord 20 100.00 Very High Very High Very High
opioid receptor 9 100.00 Very High Very High Very High
wide dynamic range 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 68 100.00 Very High Very High Very High
INFLAMMATION 52 100.00 Very High Very High Very High
Neuropathic Pain 17 100.00 Very High Very High Very High
Cv General 4 Under Development 4 99.98 Very High Very High Very High
Increased Venous Pressure Under Development 19 99.92 Very High Very High Very High
Cluster Headache 11 99.92 Very High Very High Very High
Ganglion Cysts 198 99.90 Very High Very High Very High
Rheumatoid Arthritis 7 99.80 Very High Very High Very High
Headache 144 99.68 Very High Very High Very High
Diabetes Mellitus 13 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Application of acetylcholine (ACh) to isolated rat trachea induces an increase in calcitonin gene-related peptide (CGRP) outflow in the perfusates.
Positive_regulation (induces) of Positive_regulation (increase) of calcitonin gene-related peptide in outflow associated with calcitonin gene-related peptide
1) Confidence 0.67 Published 1994 Journal Neuroreport Section Abstract Doc Link 7865762 Disease Relevance 0 Pain Relevance 0.42
Addition of bradykinin (1 microM) to the perfusate induced a 3-fold increase of CGRP-IR in the outflow, which was not significantly reduced by 10 microM RR.
Positive_regulation (induced) of Positive_regulation (increase) of CGRP-IR in outflow associated with bradykinin
2) Confidence 0.65 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2475829 Disease Relevance 0 Pain Relevance 0.69
Intravenous administration of sumatriptan, prior to electrical stimulation, prevents disintegration of perivascular terminals and induces accumulation of CGRP in terminal and preterminal portions of peripheral sensory axons.
Positive_regulation (induces) of Positive_regulation (accumulation) of CGRP associated with sumatriptan and calcitonin gene-related peptide
3) Confidence 0.61 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9185668 Disease Relevance 0.64 Pain Relevance 0.92
Intravenous administration of sumatriptan or eletriptan, prior to electrical stimulation, prevented disintegration of perivascular terminals and induced accumulation of CGRP in terminal and preterminal portions of peripheral sensory axons.
Positive_regulation (induced) of Positive_regulation (accumulation) of CGRP associated with sumatriptan and calcitonin gene-related peptide
4) Confidence 0.60 Published 2001 Journal Microsc. Res. Tech. Section Abstract Doc Link 11301495 Disease Relevance 0.57 Pain Relevance 0.75
In contrast, prior stimulation with K+ 120 mM significantly enhanced the CGRP release induced by a second stimulation with K+ 120 mM or capsaicin 10(-5) M.
Positive_regulation (enhanced) of Positive_regulation (induced) of CGRP associated with qutenza and calcitonin gene-related peptide
5) Confidence 0.50 Published 1992 Journal Peptides Section Abstract Doc Link 1377821 Disease Relevance 0 Pain Relevance 1.19
Sustained morphine induces plasticity in both primary afferents and spinal cord, including increased CGRP and dynorphin content.
Positive_regulation (induces) of Positive_regulation (increased) of CGRP in spinal cord associated with dynorphin, calcitonin gene-related peptide, spinal cord and morphine
6) Confidence 0.50 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12151554 Disease Relevance 0.17 Pain Relevance 2.00
Two weeks after triptan exposure, when sensory thresholds returned to baseline levels, rats showed enhanced cutaneous allodynia and increased CGRP in the blood following challenge with a nitric oxide donor.
Positive_regulation (enhanced) of Positive_regulation (increased) of CGRP in blood
7) Confidence 0.50 Published 2010 Journal Ann. Neurol. Section Body Doc Link 20373344 Disease Relevance 0.06 Pain Relevance 0
These data suggest that, in the pial arteries of SHR, the transient vasodilation to capsaicin and enhanced vasodilation to CGRP are related to the decreased CGRP level in the cerebral microvascular beds, consequently leading to increased sensitivity of the CGRP receptors to CGRP.
Positive_regulation (leading) of Positive_regulation (increased) of CGRP associated with qutenza, increased venous pressure under development and calcitonin gene-related peptide
8) Confidence 0.50 Published 1997 Journal Life Sci. Section Abstract Doc Link 9064474 Disease Relevance 0.48 Pain Relevance 0.63
Incubation with glyburide (10(-6) M), but not iberiotoxin (10(-7) M), specifically during the 90-minute desensitization period, mimicked the effect of CGRP8-37 and capsaicin in tolerant rings, suggesting a role for KATP channels in the effect of calcitonin gene-related peptide.
Positive_regulation (role) of Positive_regulation (effect) of calcitonin gene-related peptide associated with qutenza and calcitonin gene-related peptide
9) Confidence 0.50 Published 2006 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16495753 Disease Relevance 0 Pain Relevance 0.85
Morphine treatment induced calcitonin gene-related peptide and substance P increases in cultured dorsal root ganglion neurons.
Positive_regulation (induced) of Positive_regulation (increases) of calcitonin in dorsal root ganglion associated with ganglion cysts, root ganglion neuron, substance p, calcitonin gene-related peptide and morphine
10) Confidence 0.50 Published 2000 Journal Neuroscience Section Title Doc Link 11029544 Disease Relevance 0.39 Pain Relevance 1.34
We studied the interaction of these two vasodilatory mediators in an animal model and suggest that NO may increase meningeal blood flow not only by its direct vasodilatory action but also by stimulating CGRP release.
Spec (may) Positive_regulation (increase) of Positive_regulation (stimulating) of CGRP in blood
11) Confidence 0.50 Published 2002 Journal J. Vasc. Res. Section Abstract Doc Link 12566974 Disease Relevance 0.10 Pain Relevance 0.10
Anandamide (100 nM) did not significantly inhibit capsaicin-evoked CGRP release from the paw skin of diabetic animals, but it did produce a small stimulation of CGRP release at high concentrations (10 microM).
Positive_regulation (produce) of Positive_regulation (stimulation) of CGRP in skin associated with qutenza, diabetes mellitus and calcitonin gene-related peptide
12) Confidence 0.50 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12069907 Disease Relevance 1.02 Pain Relevance 1.73
VOA induced a concentration-dependent increase of CGRP-like enzyme immunoreactivity, which was also significantly inhibited by capsazepine.
Positive_regulation (induced) of Positive_regulation (increase) of CGRP-like enzyme associated with calcitonin gene-related peptide
13) Confidence 0.50 Published 2003 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14508237 Disease Relevance 0.21 Pain Relevance 0.37
ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater.
Positive_regulation (enhance) of Positive_regulation (proton-induced) of CGRP in dura mater
14) Confidence 0.49 Published 2002 Journal Pain Section Title Doc Link 12044622 Disease Relevance 0.26 Pain Relevance 0.21
As GDNF has been shown to promote the regeneration of both sensory and motor axons, and as CGRP appears to be involved in motoneuronal plasticity, we reason that at least some of the regenerative effects of GDNF are mediated through CGRP up-regulation.
Positive_regulation (mediated) of Positive_regulation (up-regulation) of CGRP associated with calcitonin gene-related peptide
15) Confidence 0.49 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14656320 Disease Relevance 0.24 Pain Relevance 0.66
Application of acetylcholine (ACh) to isolated rat trachea induces an increase in calcitonin gene-related peptide (CGRP) outflow in the perfusates.
Positive_regulation (induces) of Positive_regulation (increase) of CGRP in outflow associated with calcitonin gene-related peptide
16) Confidence 0.49 Published 1994 Journal Neuroreport Section Abstract Doc Link 7865762 Disease Relevance 0 Pain Relevance 0.42
Increase of salivary SP-LI and CGRP-LI as well as of plasma CGRP-LI occurred after capsaicin stimulation.
Positive_regulation (Increase) of Positive_regulation (salivary) of CGRP in plasma associated with qutenza, calcitonin gene-related peptide and substance p
17) Confidence 0.48 Published 1994 Journal Cephalalgia Section Abstract Doc Link 7520365 Disease Relevance 0.18 Pain Relevance 1.09
Increase of salivary SP-LI and CGRP-LI as well as of plasma CGRP-LI occurred after capsaicin stimulation.
Positive_regulation (Increase) of Positive_regulation (Increase) of CGRP in plasma associated with qutenza, calcitonin gene-related peptide and substance p
18) Confidence 0.48 Published 1994 Journal Cephalalgia Section Abstract Doc Link 7520365 Disease Relevance 0.18 Pain Relevance 1.11
This study tested whether the hyperalgesia and sensitizing effects of CGRP receptor activation on WDR neurons are mediated by protein kinase A or C (PKA or PKC) signaling.
Spec (whether) Positive_regulation (mediated) of Spec (whether) Positive_regulation (activation) of CGRP in neurons associated with hyperalgesia, wide dynamic range and calcitonin gene-related peptide
19) Confidence 0.47 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 15486424 Disease Relevance 0.53 Pain Relevance 1.49
After the tissue was treated with capsaicin, PNS didn't cause both the vasodilator response and the increase of CGRP-LI in the perfusate.
Positive_regulation (cause) of Positive_regulation (increase) of CGRP associated with qutenza and calcitonin gene-related peptide
20) Confidence 0.47 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2359517 Disease Relevance 0 Pain Relevance 1.05

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