INT87002

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Context Info
Confidence 0.35
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.78
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcna3)
Anatomy Link Frequency
neurons 2
L929 2
Kcna3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 7 100.00 Very High Very High Very High
intrathecal 1 99.84 Very High Very High Very High
Spinal nerve ligature 1 96.20 Very High Very High Very High
Neuropathic pain 2 94.64 High High
Spinal cord 1 87.44 High High
Dorsal horn 1 86.84 High High
Pain 5 85.12 High High
potassium channel 1 75.00 Quite High
Neuronal excitability 1 72.76 Quite High
qutenza 1 63.52 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 100.00 Very High Very High Very High
Hypoxia 6 99.14 Very High Very High Very High
Hypersensitivity 3 96.40 Very High Very High Very High
Neuropathic Pain 2 94.64 High High
Nociception 2 91.32 High High
Increased Venous Pressure Under Development 1 76.32 Quite High
Pain 3 75.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After Kv3.4 or Kv4.3 expression in lumbar DRG neurons was suppressed by intrathecal injections of antisense oligodeoxynucleotides, mechanical but not thermal hypersensitivity developed.
Negative_regulation (suppressed) of Gene_expression (expression) of Kv3 in neurons associated with dorsal root ganglion, hypersensitivity and intrathecal
1) Confidence 0.35 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17855600 Disease Relevance 1.22 Pain Relevance 1.03
Hypoxia failed to inhibit any Kv1 channel, but it inhibited Kv3.1b channels expressed in L929 cells, as shown by a reduction of whole-cell current and single-channel activity, without affecting unitary conductance.
Negative_regulation (inhibited) of Gene_expression (expressed) of Kv3 in L929 associated with hypoxia
2) Confidence 0.27 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10720415 Disease Relevance 0.57 Pain Relevance 0.06

General Comments

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