INT8701

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.19
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sciatic nerves 4
Nka1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 26 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
bradykinin 8 99.28 Very High Very High Very High
Sciatic nerve 2 98.98 Very High Very High Very High
qutenza 29 98.02 Very High Very High Very High
Potency 1 94.32 High High
tetrodotoxin 1 83.76 Quite High
antagonist 2 80.84 Quite High
Spinal cord 13 79.04 Quite High
Neuropeptide 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypotension 2 95.08 Very High Very High Very High
Ganglion Cysts 1 29.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these, peripheral electrical stimulation of the sciatic nerves (50 Hz, 50 V and 0.05 ms or 10 Hz, 10 V and 5 ms) induced an increase of the SP-LI and NKA-LI levels in the superfusates.
Positive_regulation (increase) of Gene_expression (levels) of NKA in sciatic nerves associated with sciatic nerve and substance p
1) Confidence 0.48 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.69
In these, peripheral electrical stimulation of the sciatic nerves (50 Hz, 50 V and 0.05 ms or 10 Hz, 10 V and 5 ms) induced an increase of the SP-LI and NKA-LI levels in the superfusates.
Positive_regulation (induced) of Gene_expression (levels) of NKA in sciatic nerves associated with sciatic nerve and substance p
2) Confidence 0.48 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2455922 Disease Relevance 0 Pain Relevance 0.69
In accord with the relative tissue levels of the respective peptides, capsaicin (10(-8) to 10(-5) M) and K+ (120 mM) added to the perfusate resulted in a concentration-dependent increase in the levels of CGRP and NKA, and to a minor extent SP, in the perfusates.
Positive_regulation (increase) of Gene_expression (levels) of NKA associated with qutenza, substance p and calcitonin gene-related peptide
3) Confidence 0.45 Published 1992 Journal Peptides Section Abstract Doc Link 1377821 Disease Relevance 0 Pain Relevance 0.94
NKA and NPK evoked much stronger bronchoconstrictor effects than SP, while SP was more active than NKA in inducing vascular permeability changes.
Positive_regulation (inducing) of Gene_expression (active) of NKA
4) Confidence 0.19 Published 1986 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2430427 Disease Relevance 0.19 Pain Relevance 0.58
In bronchoalveolar lavage fluid (BALF), levels of NKA and SP were significantly elevated after a bolus of BK with a phosphoramidon infusion.
Positive_regulation (elevated) of Gene_expression (levels) of NKA associated with bradykinin and substance p
5) Confidence 0.04 Published 2001 Journal Life Sci. Section Abstract Doc Link 11764001 Disease Relevance 0 Pain Relevance 0.63

General Comments

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