INT87026

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Context Info
Confidence 0.12
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.55
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ZAK, IL12A) cell differentiation (ZAK) response to stress (ZAK)
cell proliferation (ZAK) extracellular space (IL12A) cell death (ZAK)
Anatomy Link Frequency
monocytes 8
ZAK (Homo sapiens)
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 4 99.84 Very High Very High Very High
cytokine 14 97.00 Very High Very High Very High
Opioid 8 96.60 Very High Very High Very High
opioid receptor 2 77.68 Quite High
Kappa opioid receptor 2 60.96 Quite High
Disease Link Frequency Relevance Heat
Stress 2 95.76 Very High Very High Very High
Cancer 16 93.64 High High
Lymphopenia 2 93.24 High High
Bacterial Infection 4 90.40 High High
Renal Cancer 2 88.80 High High
Breast Cancer 2 87.04 High High
Hematological Disease 8 84.88 Quite High
Virus Diseases 6 75.00 Quite High
Immunodeficiency 2 75.00 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 25.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The finding that MLT stimulates IL-12 production from human monocytes only if incubated in presence of IL-2 further supports this concept.
MLT Positive_regulation (stimulates) of Gene_expression (production) of IL-12 in monocytes
1) Confidence 0.12 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.93 Pain Relevance 0.24
MLT has been reported also to enhance the production of interleukin-1, interleukin-6 and interleukin-12 in human monocytes.
MLT Positive_regulation (enhance) of Gene_expression (production) of interleukin-12 in monocytes
2) Confidence 0.12 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.64 Pain Relevance 0.36
MLT has been reported also to enhance the production of interleukin-1 (IL-1), interleukin-6 (IL-6) and interleukin-12 (IL-12) in human monocytes.
MLT Positive_regulation (enhance) of Gene_expression (production) of interleukin-12 in monocytes
3) Confidence 0.11 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10810540 Disease Relevance 0.49 Pain Relevance 0.33
MLT has been reported also to enhance the production of interleukin-1 (IL-1), interleukin-6 (IL-6) and interleukin-12 (IL-12) in human monocytes.
MLT Positive_regulation (enhance) of Gene_expression (production) of IL-12 in monocytes
4) Confidence 0.08 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10810540 Disease Relevance 0.50 Pain Relevance 0.33

General Comments

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