INT87027

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.78
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
macrophages 4
T-helper cell 4
T cells 4
blood 2
monocytes 2
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 64 100.00 Very High Very High Very High
Opioid 8 99.60 Very High Very High Very High
anesthesia 8 97.16 Very High Very High Very High
Inflammation 72 97.04 Very High Very High Very High
Dynorphin 2 96.48 Very High Very High Very High
aspirin 9 95.56 Very High Very High Very High
fibrosis 8 94.32 High High
Inflammatory mediators 22 86.76 High High
rheumatoid arthritis 112 86.40 High High
methotrexate 22 78.72 Quite High
Disease Link Frequency Relevance Heat
Sarcoidosis 14 99.68 Very High Very High Very High
Granuloma 4 99.18 Very High Very High Very High
Cancer 28 99.16 Very High Very High Very High
Necrosis 12 98.92 Very High Very High Very High
INFLAMMATION 100 97.04 Very High Very High Very High
Stress 4 95.36 Very High Very High Very High
Cystic Fibrosis 6 94.88 High High
Disease 49 93.68 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 93.44 High High
Sprains And Strains 2 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-18 immunoneutralization resulted in a 60-80% reduction of IL-1beta, IL-8, IFN-gamma, and TNF-alpha release from LPS-stimulated monocytes.
Positive_regulation (resulted) of Localization (release) of IFN-gamma in monocytes
1) Confidence 0.67 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.15 Pain Relevance 0.31
Experiments revealed that blood mononuclear cells and lymphocytes with CFTR dysfunction exhibited a reduced potential for secretion of the cytokines IL-10 and IFN gamma [115,116].
Positive_regulation (potential) of Localization (secretion) of IFN gamma in blood associated with cytokine
2) Confidence 0.29 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.43 Pain Relevance 0.37
RESULTS: After antigen-specific stimulation with the G1 protein, the CD4+ T cells of 30 AS patients (61.7%) and of 12 RA patients (54.5%) secreted significant amounts of IFN gamma and TNF alpha, while, in contrast, only 10% of the normal controls showed a response (P < 0.05).
Positive_regulation (stimulation) of Localization (secreted) of IFN gamma in T cells
3) Confidence 0.27 Published 2003 Journal Rheumatology (Oxford) Section Body Doc Link 12730543 Disease Relevance 0 Pain Relevance 0
RESULTS: After antigen-specific stimulation with the G1 protein, the CD4+ T cells of 30 AS patients (61.7%) and of 12 RA patients (54.5%) secreted significant amounts of IFN gamma and TNF alpha, while, in contrast, only 10% of the normal controls showed a response (P < 0.05).
Positive_regulation (amounts) of Localization (secreted) of IFN gamma in T cells
4) Confidence 0.27 Published 2003 Journal Rheumatology (Oxford) Section Body Doc Link 12730543 Disease Relevance 0 Pain Relevance 0
The addition of CPG 7909 to the 1/10th dose of Fluarix did however result in significantly higher levels of IFN-gamma secretion from peripheral blood mononuclear cells recovered at 4 weeks and restimulated ex vivo with A/Beijing/262/95 (P = 0.048) and B/Harbin/7/94 (P = 0.0057), restoring these to the level seen with full-dose vaccine.
Positive_regulation (levels) of Localization (secretion) of IFN-gamma in mononuclear cells
5) Confidence 0.27 Published 2004 Journal Vaccine Section Abstract Doc Link 15297066 Disease Relevance 0.47 Pain Relevance 0.11
Upregulation of IFN-gamma and soluble interleukin-2 receptor release and altered serum cortisol and prolactin concentration during general anesthesia.
Positive_regulation (Upregulation) of Localization (release) of IFN-gamma associated with anesthesia
6) Confidence 0.22 Published 2001 Journal J. Interferon Cytokine Res. Section Title Doc Link 11710990 Disease Relevance 0.23 Pain Relevance 0.72
Besides the release of proinflammatory Th-1 cytokines, such as IFN-gamma and IL2 administration of melatonin to antigen-primed mice increased the production of IL10, indicating that melatonin can also activate anti-inflammatory Th-2-like immune responses in certain circumstances [128].
Positive_regulation (increased) of Localization (administration) of IFN-gamma associated with inflammation and cytokine
7) Confidence 0.14 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.53 Pain Relevance 0.13
Granuloma formation in sarcoidosis is mediated by increased secretion of interferon-gamma, interleukin-2, and tumor necrosis factor-alpha. 25% of patients with neurosarcoidosis are steroid resistant and another 20–40% are resistant to any conventional immunosuppression, but the typical agents suppress the immune system in a non-specific fashion.
Positive_regulation (increased) of Localization (secretion) of interferon-gamma in immune system associated with necrosis, cancer, sarcoidosis and granuloma
8) Confidence 0.08 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2249602 Disease Relevance 0.89 Pain Relevance 0.04
Activation of MLT receptors enhances the release of T-helper cell cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as activation of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.
Positive_regulation (enhances) of Localization (release) of gamma-interferon in T-helper cell associated with dynorphin, opioid and cytokine
9) Confidence 0.08 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.49 Pain Relevance 0.33
Activation of MLT receptors enhances the release of T-helper cell cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as activation of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.
Positive_regulation (activation) of Localization (release) of gamma-interferon in T-helper cell associated with dynorphin, opioid and cytokine
10) Confidence 0.08 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.51 Pain Relevance 0.34
It is possible that secretion of interferon gamma from these activated T cells may activate macrophages to produce TNF-?.
Positive_regulation (activate) of Localization (secretion) of interferon gamma in macrophages
11) Confidence 0.05 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 1.04 Pain Relevance 0.50
It is possible that secretion of interferon gamma from these activated T cells may activate macrophages to produce TNF-?.
Positive_regulation (activated) of Localization (secretion) of interferon gamma in macrophages
12) Confidence 0.05 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 1.03 Pain Relevance 0.50

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