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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 8.17
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
NK cell 4
monocytes 2
T lymphocytes 2
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 72 100.00 Very High Very High Very High
Inflammation 62 100.00 Very High Very High Very High
dexamethasone 5 98.12 Very High Very High Very High
rheumatoid arthritis 67 87.84 High High
Paracetamol 1 85.88 High High
psoriasis 3 74.16 Quite High
chemokine 84 72.76 Quite High
Arthritis 10 72.40 Quite High
opioid receptor 1 68.20 Quite High
Opioid 2 66.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 64 100.00 Very High Very High Very High
Lymphatic System Cancer 27 98.80 Very High Very High Very High
Syndrome 73 98.12 Very High Very High Very High
Hypersensitivity 10 97.48 Very High Very High Very High
Sepsis 6 95.76 Very High Very High Very High
Encephalopathy 7 94.20 High High
Metastasis 10 93.52 High High
Death 13 93.00 High High
Recurrence 28 92.60 High High
Breast Cancer 1 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed IL-2 increase might also be due to an increase in the number of DCs.
Positive_regulation (increase) of Positive_regulation (increase) of IL-2
1) Confidence 0.50 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.22 Pain Relevance 0
The serum levels of IL-6 and soluble IL-2 receptors were increased in our patients, however, the degree of the increase varied in each patient.
Positive_regulation (increased) of Positive_regulation (increase) of IL-2
2) Confidence 0.49 Published 2008 Journal BMC Pediatr Section Body Doc Link PMC2577649 Disease Relevance 1.74 Pain Relevance 0.14
The finding that MLT stimulates IL-12 production from human monocytes only if incubated in presence of IL-2 further supports this concept.
Positive_regulation (incubated) of Positive_regulation (presence) of IL-2 in monocytes
3) Confidence 0.44 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.91 Pain Relevance 0.16
To explore whether steroid premedication would improve the tolerability of DAB(389)IL-2, we treated 15 patients with CTCL with either dexamethasone or prednisone prior to each dose of DAB(389)IL-2.
Spec (whether) Positive_regulation (improve) of Spec (whether) Positive_regulation (tolerability) of IL-2 associated with lymphatic system cancer and dexamethasone
4) Confidence 0.38 Published 2001 Journal Clin Lymphoma Section Abstract Doc Link 11707845 Disease Relevance 1.41 Pain Relevance 0.17
secretion and augmented the cytotoxic function of IL-2 activated NK cells against these cells (Fig. 2).
Positive_regulation (augmented) of Positive_regulation (activated) of IL-2 in NK cells
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.46 Pain Relevance 0.03
NK cell phenotype and in vitro cytolytic activity after TKD/IL-2 stimulation
Positive_regulation (after) of Positive_regulation (stimulation) of TKD/IL-2 in NK cell
6) Confidence 0.18 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 1.15 Pain Relevance 0
Similarly, it was shown for T lymphocytes that after activation with interleukin-2 the expression of CXCR3 is upregulated [32].
Positive_regulation (upregulated) of Positive_regulation (activation) of interleukin-2 in T lymphocytes
7) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.39 Pain Relevance 0.29
Activation of this cascade results in the upregulation of inflammatory cytokines such as IL-2 and interferon (IFN)-?
Positive_regulation (results) of Positive_regulation (upregulation) of IL-2 associated with inflammation and cytokine
8) Confidence 0.04 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.89 Pain Relevance 0.42
H. pylori-pulsed DC induce increased IL-2, IFN-?
Positive_regulation (induce) of Positive_regulation (increased) of IL-2
9) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 1.00 Pain Relevance 0.15

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