INT87043

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Context Info
Confidence 0.06
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.26
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
adipocytes 1
Eif4ebp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 7 83.44 Quite High
Potency 1 53.20 Quite High
Gabapentin 1 25.00 Low Low
antagonist 1 25.00 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
nalbuphine 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 5 98.56 Very High Very High Very High
Neointima 11 40.48 Quite Low
Weight Gain 1 35.68 Quite Low
Insulin Resistance 2 32.00 Quite Low
Diabetes Mellitus 7 27.12 Quite Low
Heart Rate Under Development 5 25.44 Quite Low
Injury 16 14.80 Low Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Sepsis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, if real, reduced AKT Ser473 phosphorylation would appear to have had no significant impact on the two downstream translation initiation intermediates p70 S6K and 4E-BP1.
Neg (no) Positive_regulation (intermediates) of 4E-BP1
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
activation reduces mitogen-induced VSMC growth by inhibition of Akt activity and increase of phosphorylated forms of 4E-BP1.
Positive_regulation (increase) of 4E-BP1
2) Confidence 0.03 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0 Pain Relevance 0.04
In adipocytes, amino acids stimulate the target of rapamycin (TOR) signaling pathway leading to phosphorylation of the translational repressor, eIF-4E binding protein-I (4E-BP1), and ribosomal protein S6.
Positive_regulation (leading) of 4E-BP1 in adipocytes associated with obesity
3) Confidence 0.01 Published 2000 Journal J. Cell. Biochem. Section Abstract Doc Link 10723090 Disease Relevance 0.26 Pain Relevance 0.03

General Comments

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