INT87050

Context Info Confidence 0.49 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.26 Pain Relevance 0.03

structural constituent of ribosome (RPS6) ribosome (RPS6) intracellular (RPS6) cytoplasm (RPS6) cytosol (RPS6) mitosis (RPS6)

Anatomy Link Frequency adipocytes 1 RPS6 (Homo sapiens)

Pain Link Frequency Relevance Heat Potency 1 55.36 agonist 4 33.84 antagonist 1 27.12 Gabapentin 1 25.00

Disease Link Frequency Relevance Heat Obesity 4 98.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In adipocytes, amino acids stimulate the target of rapamycin (TOR) signaling pathway leading to phosphorylation of the translational repressor, eIF-4E binding protein-I (4E-BP1), and ribosomal protein S6.

Positive_regulation (leading) of ribosomal protein S6 in adipocytes associated with obesity

1) Confidence 0.49 Published 2000 Journal J. Cell. Biochem. Section Abstract Doc Link 10723090 Disease Relevance 0.26 Pain Relevance 0.03

General Comments

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