INT87062

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 11.80
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
neutrophils 6
white blood cell 4
macrophages 2
cartilage 2
cerebrospinal fluid 2
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 31 99.56 Very High Very High Very High
Osteoarthritis 63 98.90 Very High Very High Very High
Inflammation 101 92.72 High High
headache 17 92.52 High High
Pain 5 91.12 High High
imagery 8 77.60 Quite High
Kinase C 6 68.24 Quite High
Bile 2 66.12 Quite High
alcohol 6 8.76 Low Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 34 100.00 Very High Very High Very High
Cancer 12 100.00 Very High Very High Very High
Necrosis 13 99.64 Very High Very High Very High
INFLAMMATION 152 99.24 Very High Very High Very High
Osteoarthritis 66 98.90 Very High Very High Very High
Leukemia 2 97.80 Very High Very High Very High
Htlv Types I And Ii 4 95.28 Very High Very High Very High
Hypertension 27 95.04 Very High Very High Very High
Obesity 54 94.32 High High
Diabetes Mellitus 125 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Syndrome of inappropriate antidiuretic hormone secretion associated with meningeal infiltration of tumor cells and elevated interleukin-1 beta and interleukin-6 in cerebrospinal fluid of a patient with adult T-cell leukemia].
Positive_regulation ([Syndrome) of interleukin-6 Binding (associated) of in cerebrospinal fluid associated with leukemia, cancer and syndrome
1) Confidence 0.49 Published 2000 Journal Rinsho Ketsueki Section Title Doc Link 10723244 Disease Relevance 1.05 Pain Relevance 0.22
We observed the strongest association between IL-6 and O3 using the 4-day moving average: a 0.31 SD increase in IL-6 per O3 IQR [95% confidence interval (CI), 0.08–0.54].
Positive_regulation (increase) of IL-6 Binding (association) of
2) Confidence 0.49 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0 Pain Relevance 0
At baseline, venous blood sample were taken after an overnight fast for DNA extraction, white blood cell immortalisation, measurement of plasma c-reactive protein, fibrinogen, interleukin-6, tissue necrosis factor-?
Positive_regulation (measurement) of interleukin-6 Binding (extraction) of in white blood cell associated with necrosis
3) Confidence 0.49 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2621220 Disease Relevance 0.53 Pain Relevance 0.07
At baseline, venous blood sample were taken after an overnight fast for DNA extraction, white blood cell immortalisation, measurement of plasma c-reactive protein, fibrinogen, interleukin-6, tissue necrosis factor-?
Positive_regulation (measurement) of interleukin-6 Binding (fibrinogen) of in white blood cell associated with necrosis
4) Confidence 0.49 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2621220 Disease Relevance 0.52 Pain Relevance 0.07
NO2 associations with IL-6 were elevated both in summer (marginally) and in winter.
Positive_regulation (elevated) of IL-6 Binding (associations) of
5) Confidence 0.45 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0 Pain Relevance 0
enhanced associations with CRP, IL-6, and WBCs.
Positive_regulation (enhanced) of IL-6 Binding (associations) of
6) Confidence 0.42 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1513328 Disease Relevance 1.53 Pain Relevance 0.15
In conclusion, OA cartilage was shown to respond to leptin by producing increased amounts of NO, PGE2, IL-6, IL-8, and all those effects can be considered harmful in cartilage metabolism.
Positive_regulation (increased) of IL-6 Neg (NO) Binding (amounts) of in cartilage associated with osteoarthritis
7) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.46 Pain Relevance 0.32
Bronchoalveolar lavage (BAL) fluid following endotoxin instillation shows increased numbers of macrophages and neutrophils along with increased concentrations of interleukin-6 (IL-6), IL-8, IL-1?
Positive_regulation (increased) of interleukin-6 Binding (concentrations) of in neutrophils
8) Confidence 0.12 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2701955 Disease Relevance 1.92 Pain Relevance 0.15
Bronchoalveolar lavage (BAL) fluid following endotoxin instillation shows increased numbers of macrophages and neutrophils along with increased concentrations of interleukin-6 (IL-6), IL-8, IL-1?
Positive_regulation (increased) of IL-6 Binding (concentrations) of in neutrophils
9) Confidence 0.12 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2701955 Disease Relevance 1.93 Pain Relevance 0.15
Bronchoalveolar lavage (BAL) fluid following endotoxin instillation shows increased numbers of macrophages and neutrophils along with increased concentrations of interleukin-6 (IL-6), IL-8, IL-1?
Positive_regulation (increased) of interleukin-6 in macrophages Binding (concentrations) of in neutrophils
10) Confidence 0.04 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2701955 Disease Relevance 1.92 Pain Relevance 0.15
Bronchoalveolar lavage (BAL) fluid following endotoxin instillation shows increased numbers of macrophages and neutrophils along with increased concentrations of interleukin-6 (IL-6), IL-8, IL-1?
Positive_regulation (increased) of IL-6 in macrophages Binding (concentrations) of in neutrophils
11) Confidence 0.04 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2701955 Disease Relevance 1.93 Pain Relevance 0.15

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