INT871

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Context Info
Confidence 0.58
First Reported 1977
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 53
Total Number 55
Disease Relevance 18.89
Pain Relevance 17.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 10
lactotrophs 6
pituitary 6
glands 4
forebrain 2
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 90 100.00 Very High Very High Very High
Dopamine 76 100.00 Very High Very High Very High
opiate 24 100.00 Very High Very High Very High
Clonidine 13 100.00 Very High Very High Very High
Fibrositis 12 100.00 Very High Very High Very High
Morphine 28 99.98 Very High Very High Very High
antagonist 137 99.96 Very High Very High Very High
narcan 64 99.84 Very High Very High Very High
Buprenorphine 20 99.84 Very High Very High Very High
anesthesia 10 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 170 100.00 Very High Very High Very High
Cancer 126 100.00 Very High Very High Very High
Depression 81 100.00 Very High Very High Very High
Disease 78 100.00 Very High Very High Very High
Celiac Disease 43 100.00 Very High Very High Very High
Acute Coronary Syndrome 7 99.98 Very High Very High Very High
Decapitation 10 99.96 Very High Very High Very High
Eating Disorder 19 99.24 Very High Very High Very High
Myocardial Infarction 2 99.14 Very High Very High Very High
Prolactinoma 14 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A median optimal dose of 50 micrograms pergolide and 5 mg bromocriptine/day suppressed PRL levels in the 61 patients of trial I by more than 80%.
Negative_regulation (suppressed) of Gene_expression (levels) of PRL
1) Confidence 0.58 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1997518 Disease Relevance 0.87 Pain Relevance 0
Further, it has been shown that incubation in 3H-leucine of anterior pituitary glands from these tumor-bearing rats demonstrates a marked inhibition of 3H-prolactin synthesis and release.
Negative_regulation (inhibition) of Gene_expression (synthesis) of 3H-prolactin in glands associated with cancer
2) Confidence 0.58 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 7266770 Disease Relevance 0.43 Pain Relevance 0.51
To answer this question, we injected post-partum animals with estradiol benzoate plus bromoergocryptine in order to block the production of pituitary prolactin induced by the estrogen.
Negative_regulation (block) of Gene_expression (production) of prolactin in pituitary
3) Confidence 0.58 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.11 Pain Relevance 0
These conflicting results indicate that the reduction in prolactin protein results from inhibition of prolactin protein synthesis, acceleration of prolactin release, or enhancement of prolactin digestion in the rE-cad-IZ-transfected lactotrophs.
Negative_regulation (inhibition) of Gene_expression (synthesis) of prolactin in lactotrophs associated with coronary artery disease
4) Confidence 0.45 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.33 Pain Relevance 0
During late pregnancy, TIDA neuronal activity is reduced allowing the expression of an antepartum PRL surge.
Negative_regulation (reduced) of Gene_expression (expression) of PRL in neuronal associated with dopamine
5) Confidence 0.43 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12123859 Disease Relevance 0 Pain Relevance 0.56
Naloxone administration did not decrease previously increased mean serum levels of prolactin in pituitary-grafted rats.
Neg (not) Negative_regulation (decrease) of Gene_expression (levels) of prolactin in pituitary associated with narcan
6) Confidence 0.43 Published 1994 Journal Vet Hum Toxicol Section Abstract Doc Link 7900271 Disease Relevance 0.07 Pain Relevance 0.72
Training the animals to be handled prevented the increase in plasma prolactin levels produced by decapitation; training had no influence on the decapitation-induced rises in plasma CA concentrations.
Negative_regulation (prevented) of Gene_expression (produced) of prolactin in plasma associated with catecholamine and decapitation
7) Confidence 0.43 Published 1981 Journal J Pharmacol Methods Section Abstract Doc Link 7311568 Disease Relevance 0.20 Pain Relevance 0.36
In the unanesthetized normal male rat, 5 micrograms AVT first increased and then decreased levels of prolactin.
Negative_regulation (decreased) of Gene_expression (levels) of prolactin
8) Confidence 0.43 Published 1980 Journal Horm. Res. Section Abstract Doc Link 6785180 Disease Relevance 0 Pain Relevance 0.22
There was a marked decrease in PRL levels and in tumor size.
Negative_regulation (decrease) of Gene_expression (levels) of PRL associated with cancer
9) Confidence 0.43 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8862506 Disease Relevance 1.29 Pain Relevance 0.09
IDZ significantly lowered plasma PRL levels in OET rats; no elevated PRL values were observed in normal cycling rats, indicating that IDZ might inhibit PRL surges in these animals.
Negative_regulation (lowered) of Gene_expression (levels) of PRL in plasma
10) Confidence 0.43 Published 1991 Journal Horm. Metab. Res. Section Abstract Doc Link 2016076 Disease Relevance 0.24 Pain Relevance 0.12
We found that: the reduction in serotoninergic activity after PCPA administration did not modify serum PRL concentrations; the stimulatory effect of 5-HTP on PRL secretion was not observed before day 16; the effects of 5-HTP or 5-HTP and fluoxetine were similar in intact and orchidectomized males; a significant increase in PRL secretion took place after 8-OH-DPAT administration; the duration of the stimulatory effect of 5-HTP increased after alpha-diol treatment; and pituitary PRL content increased after 5-HTP injection in intact males and decreased in castrated males treated with testosterone or alpha-diol.
Negative_regulation (decreased) of Gene_expression (content) of PRL in pituitary associated with fluoxetine
11) Confidence 0.43 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7524955 Disease Relevance 0 Pain Relevance 0.22
Naloxone (0.2 mg/kg, iv) administered at 0930 h suppressed basal 1000 h PRL levels on each day of the estrous cycle, but had no effect on the PRL surges occurring on the afternoon of proestrus and estrus.
Negative_regulation (suppressed) of Gene_expression (levels) of PRL associated with narcan
12) Confidence 0.43 Published 1985 Journal Endocrinology Section Abstract Doc Link 4040459 Disease Relevance 0 Pain Relevance 0.48
In Holtzman rats CB-154 decreased prolactin levels measured by RIA and BA to the same extent at both 1 and 4 weeks resulting in no change in the BA:RIA ratio, but at 8 weeks the BA:RIA was decreased by CB-154 (2.1 +/- 0.1 to 1.7 +/- 0.1).
Negative_regulation (decreased) of Gene_expression (levels) of prolactin
13) Confidence 0.43 Published 1993 Journal Life Sci. Section Abstract Doc Link 8412487 Disease Relevance 0.15 Pain Relevance 0.16
In Holtzman rats CB-154 decreased prolactin levels measured by RIA and BA to the same extent at both 1 and 4 weeks resulting in no change in the BA:RIA ratio, but at 8 weeks the BA:RIA was decreased by CB-154 (2.1 +/- 0.1 to 1.7 +/- 0.1).
Negative_regulation (decreased) of Gene_expression (levels) of prolactin
14) Confidence 0.43 Published 1993 Journal Life Sci. Section Abstract Doc Link 8412487 Disease Relevance 0.15 Pain Relevance 0.16
In the same experiment clonidine, 0.2 mg/kg, suppressed basal prolactin levels to 4 +/- 1 ng/ml and returned prolactin levels of all animals receiving 0.2-5.0 mg/kg yohimbine to basal levels.
Negative_regulation (returned) of Gene_expression (levels) of prolactin associated with clonidine
15) Confidence 0.43 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3025757 Disease Relevance 0 Pain Relevance 0.50
On day 13, ketanserin and pCPA had no effect on serum prolactin levels, but after increasing serotoninergic transmission by injecting fluoxetine and 5-hydroxytryptophan, serum prolactin levels were decreased.
Negative_regulation (decreased) of Gene_expression (levels) of prolactin associated with fluoxetine
16) Confidence 0.43 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 2969029 Disease Relevance 0 Pain Relevance 0.24
Acute administration of lisuride (100 microgram orally) significantly suppressed serum prolactin (PRL) levels in nine out of eleven subjects.
Negative_regulation (suppressed) of Gene_expression (levels) of PRL
17) Confidence 0.43 Published 1978 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 106990 Disease Relevance 0.34 Pain Relevance 0.07
Domperidone (1mg/kg), a peripherally active D2 receptor antagonist, administered prior to the morphine challenge, attenuated the opiate-induced PRL suppression in EB/oil-treated animals suggesting that a dopaminergic mechanism is involved in this paradoxical response to morphine.
Negative_regulation (attenuated) of Gene_expression (suppression) of PRL associated with antagonist, opiate and morphine
18) Confidence 0.43 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1407373 Disease Relevance 0 Pain Relevance 0.62
The results revealed that the MR-2266-BS of 3 mg/kg completely blocked the restraint stress-induced increase in plasma ACTH levels, and further elevated plasma PRL levels in these animals, while there were no effects on the resting levels of ACTH and PRL.
Negative_regulation (blocked) of Gene_expression (levels) of PRL in plasma associated with stress
19) Confidence 0.42 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2557673 Disease Relevance 0.25 Pain Relevance 0.39
Serum levels of Prl were decreased by approximately 50% in IPL nude compared to normal Sprague-Dawley rats, regardless of the method used for collection of the samples.
Negative_regulation (decreased) of Gene_expression (levels) of Prl
20) Confidence 0.42 Published 1983 Journal Biol. Reprod. Section Abstract Doc Link 6403064 Disease Relevance 0.41 Pain Relevance 0.22

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