INT8713

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Context Info
Confidence 0.60
First Reported 1985
Last Reported 2010
Negated 6
Speculated 9
Reported most in Abstract
Documents 56
Total Number 66
Disease Relevance 25.29
Pain Relevance 45.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
neurons 3
brain 2
hippocampus 2
nasal 2
spinal cord 2
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 331 100.00 Very High Very High Very High
Pain 180 100.00 Very High Very High Very High
antagonist 104 100.00 Very High Very High Very High
qutenza 98 100.00 Very High Very High Very High
Opioid 92 100.00 Very High Very High Very High
Inflammation 81 100.00 Very High Very High Very High
Enkephalin 65 100.00 Very High Very High Very High
Serotonin 54 100.00 Very High Very High Very High
Calcitonin gene-related peptide 38 100.00 Very High Very High Very High
central sensitization 32 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 89 100.00 Very High Very High Very High
Metastasis 14 100.00 Very High Very High Very High
Breast Cancer 6 100.00 Very High Very High Very High
Aggression 3 100.00 Very High Very High Very High
Targeted Disruption 66 99.96 Very High Very High Very High
Pain 197 99.84 Very High Very High Very High
Nervous System Injury 11 99.82 Very High Very High Very High
Parkinson's Disease 24 99.56 Very High Very High Very High
Osteoarthritis 10 99.56 Very High Very High Very High
Nociception 38 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results with analogues of substance P support the hypothesis that substance P, injected intrathecally, acts directly on substance P receptors in the spinal cord.
Regulation (acts) of substance P in spinal cord associated with spinal cord and substance p
1) Confidence 0.60 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 2444899 Disease Relevance 0.33 Pain Relevance 1.12
This study examined the role of neurokinin peptides in 3- and 21-day-old rat pups using the preprotachykinin-A (PPTA) knockout mouse, lacking neurokinin A and substance P.
Spec (examined) Regulation (role) of neurokinin associated with targeted disruption and substance p
2) Confidence 0.45 Published 2003 Journal Neuroreport Section Abstract Doc Link 14502084 Disease Relevance 0.33 Pain Relevance 0.17
The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test.
Regulation (effects) of NK1 in tail associated with antidepressant and antagonist
3) Confidence 0.45 Published 2003 Journal Behav Pharmacol Section Title Doc Link 12576885 Disease Relevance 0 Pain Relevance 0.59
Role of the tachykinin NK(1) receptor in mediating contraction to 5-hydroxytryptamine and antigen in the mouse trachea.
Regulation (Role) of tachykinin in trachea
4) Confidence 0.44 Published 2007 Journal Pulm Pharmacol Ther Section Title Doc Link 16919985 Disease Relevance 0.44 Pain Relevance 0.22
In contrast, expression levels of mRNA for the Runx1-independent neuropeptides CGRP and Substance P/Tachykinin 1 (SP/Tac1) were little changed (Figure 3B), consistent with past results [16,17].
Neg (little) Regulation (changed) of Tac1 associated with calcitonin gene related peptide, neuropeptide and substance p
5) Confidence 0.44 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.53 Pain Relevance 1.06
Finally, other more recent publications suggest a role for NK1 receptor antagonists as tumour suppressants and haematopoietic agents.
Regulation (role) of NK1 associated with cancer and antagonist
6) Confidence 0.44 Published 2004 Journal Expert Opin Emerg Drugs Section Abstract Doc Link 15155133 Disease Relevance 1.09 Pain Relevance 0.75
The NK1 receptor agonist influences the accumulation of monocytes in addition to that of PMN by 4 h, thus revealing an important influence of the NK1 receptor on TNFalpha mediated events in mouse skin.
Regulation (influence) of NK1 in skin associated with agonist
7) Confidence 0.43 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16269189 Disease Relevance 0.34 Pain Relevance 0.28
[Why are substance P(NK1)-receptor antagonists ineffective in pain treatment?].
Regulation (ineffective) of NK1 associated with pain, analgesic, antagonist and substance p
8) Confidence 0.39 Published 2002 Journal Anaesthesist Section Title Doc Link 12063723 Disease Relevance 0.60 Pain Relevance 1.41
We studied the behavioral responses of NK-1 knockout and wild-type control mice to thermal and mechanical stimuli before and after inducing chronic neuropathic pain by unilateral ligation of the L5 spinal nerve.
Regulation (responses) of NK-1 in spinal nerve associated with targeted disruption and neuropathic pain
9) Confidence 0.39 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10739640 Disease Relevance 0.91 Pain Relevance 0.60
These results suggest that while some pharmacological manipulations appear to alter TRH and PPT mRNA levels coordinately, the mechanisms regulating the synthesis of these two colocalized neurotransmitters are different.
Regulation (alter) of PPT mRNA associated with neurotransmitter
10) Confidence 0.38 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8389958 Disease Relevance 0 Pain Relevance 0.54
Serotonin modulates the levels of mRNAS coding for thyrotropin-releasing hormone and preprotachykinin by different mechanisms in medullary raphe neurons.
Regulation (modulates) of preprotachykinin in neurons associated with raphe and serotonin
11) Confidence 0.28 Published 1993 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8389958 Disease Relevance 0 Pain Relevance 0.59
The aims of this study were to determine (i) whether striatal neuropeptides (dynorphin, enkephalin 1, substance P, cholecystokinin) and dopamine receptors 1 and 2 (D1r and D2r) are regulated by the molecular clock; and (ii) when their oscillations start after birth.
Spec (whether) Regulation (regulated) of substance P associated with dynorphin, dopamine receptor, neuropeptide, enkephalin, cholecystokinin and substance p
12) Confidence 0.26 Published 2010 Journal Neuroreport Section Abstract Doc Link 20009962 Disease Relevance 0 Pain Relevance 0.52
The propyl-analogue (II) cannot be used for detecting changes in NK1-ligand levels, while further studies should be performed with the ethyl-analogue (I).



Regulation (changes) of NK1
13) Confidence 0.26 Published 2007 Journal BMC Med Imaging Section Abstract Doc Link PMC1959516 Disease Relevance 0 Pain Relevance 0
Alteration in the levels of thyrotropin releasing hormone, substance P and enkephalins in the spinal cord, brainstem, hypothalamus and midbrain of the Wobbler mouse at different stages of the motoneuron disease.
Regulation (Alteration) of substance P in spinal cord associated with medulla, midbrain, enkephalin, disease, spinal cord and substance p
14) Confidence 0.26 Published 1992 Journal Neuroscience Section Title Doc Link 1383870 Disease Relevance 0.45 Pain Relevance 1.11
Neonatal capsaicin exposure affects isolation-induced aggressive behavior and hypothalamic substance P levels of adult male mice (Mus musculus).
Regulation (affects) of substance P associated with qutenza, aggression and substance p
15) Confidence 0.24 Published 1993 Journal Behav. Neurosci. Section Title Doc Link 7683473 Disease Relevance 0.28 Pain Relevance 0.94
Because a significant part of sensory innervation of lung tissue is supplied by the vagus nerve, we here examined the effects of unilateral mid-cervical vagotomy in the metastases of 4THMpc breast carcinoma and tissue Substance P (SP) levels.
Spec (examined) Regulation (effects) of Substance P in lung associated with breast cancer, vagus nerve, metastasis and substance p
16) Confidence 0.24 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18499282 Disease Relevance 0.84 Pain Relevance 0.34
Vagotomy enhances experimental metastases of 4THMpc breast cancer cells and alters substance P level.
Regulation (alters) of substance P associated with breast cancer, metastasis and substance p
17) Confidence 0.24 Published 2008 Journal Regul. Pept. Section Title Doc Link 18499282 Disease Relevance 0.91 Pain Relevance 0.43
Since the structure and the pharmacology of the human neurokinin receptor resembles that of gerbils, rather than that of mice or rats, we decided to investigate the anxiolytic- and /or antidepressant-like effects of NK1 (SSR240600), NK2 (saredutant) and NK3 (osanetant) receptor antagonists in gerbils.
Regulation (effects) of NK1 associated with antidepressant, antagonist and anxiety disorder
18) Confidence 0.23 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16624395 Disease Relevance 0.35 Pain Relevance 0.34
No change in the cellular abundance of preprotachykinin messenger RNA was observed in cells of the insular cortex or a small discrete population of large cells (208 +/- 27 microns2) in the ventral putamen.
Neg (No) Regulation (change) of preprotachykinin in putamen
19) Confidence 0.23 Published 1995 Journal Neuroscience Section Abstract Doc Link 8544992 Disease Relevance 0.51 Pain Relevance 0.08
We also investigated the effects of ginsenosides on substance P (SP) induced-pain behaviors by i.t. treatment using mice.
Spec (investigated) Regulation (effects) of substance P associated with pain and substance p
20) Confidence 0.21 Published 1998 Journal Life Sci. Section Abstract Doc Link 9619848 Disease Relevance 0.30 Pain Relevance 0.63

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