INT87168

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2000
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 4
Total Number 12
Disease Relevance 4.60
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 39 100.00 Very High Very High Very High
cva 12 99.02 Very High Very High Very High
adenocard 2 98.60 Very High Very High Very High
cerebral cortex 37 96.36 Very High Very High Very High
Inflammation 175 95.12 Very High Very High Very High
Kinase C 5 93.12 High High
Sciatic nerve 9 91.00 High High
spinal dorsal horn 4 84.80 Quite High
Central grey 87 83.12 Quite High
Peripheral nerve injury 1 75.96 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 90 99.98 Very High Very High Very High
Hemorrhage 19 99.02 Very High Very High Very High
Shock 49 98.64 Very High Very High Very High
Hemorrhagic Shock 138 96.24 Very High Very High Very High
Stress 121 95.44 Very High Very High Very High
Pneumonia 42 95.12 Very High Very High Very High
INFLAMMATION 139 93.40 High High
Urological Neuroanatomy 95 83.12 Quite High
Cognitive Disorder 11 79.60 Quite High
Nervous System Injury 3 75.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rat neurokinin-1 (NK1) receptor gene contains a cyclic adenosine monophosphate (cAMP) response element, and gene transcription may be activated upon binding of phosphorylated cAMP response element binding protein (pCREB).
Spec (may) Positive_regulation (activated) of pCREB Binding (binding) of associated with adenocard
1) Confidence 0.48 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10729626 Disease Relevance 0.07 Pain Relevance 0.12
HSPTX-treated animals demonstrated a 93% increase in the association of CREB and DNA over their RL counterparts (193 ± 11 vs. 100; p = 0.001) (Figure 5).
Positive_regulation (increase) of CREB Binding (association) of
2) Confidence 0.47 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.51 Pain Relevance 0.15
We report that curcumin supplementation reduces diabetes induced alteration of dopamine D1, D2 receptors, transcription factor CREB and phospholipase C to near control.
Positive_regulation (induced) of CREB Binding (alteration) of associated with dopamine and diabetes mellitus
3) Confidence 0.47 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.81 Pain Relevance 0.45
Combined application of the ERK1/2 and CaMKII inhibitors also attenuated the ligation-associated CREB activation but not to a greater extent than either inhibitor alone.
Positive_regulation (activation) of CREB Binding (ligation-associated) of
4) Confidence 0.46 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882794 Disease Relevance 0.21 Pain Relevance 0.46
the stressed and Handled CREB group had elevated pCREB lir in the right hemisphere as compared to the left

(all t,

P < .04 t tailed) with the Handled GFP control group again showing
Positive_regulation (elevated) of pCREB Binding (lir) of
5) Confidence 0.43 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.16 Pain Relevance 0.12
The rat neurokinin-1 (NK1) receptor gene contains a cyclic adenosine monophosphate (cAMP) response element, and gene transcription may be activated upon binding of phosphorylated cAMP response element binding protein (pCREB).
Spec (may) Positive_regulation (activated) of phosphorylated cAMP response element binding protein Binding (binding) of associated with adenocard
6) Confidence 0.42 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10729626 Disease Relevance 0.07 Pain Relevance 0.12
These data are supported by the findings of Shenkar et al., who similarly demonstrated that inhibition of xanthine oxidase and production of reactive oxygen species in mice before hemorrhage reduced interactions between p65 and CBP, while CREB-CBP associations were significantly increased.11
Positive_regulation (increased.11) of CREB Binding (associations) of associated with cva
7) Confidence 0.34 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.51 Pain Relevance 0.26
Given that an increased association between CBP and CREB was evident with HSPTX, we sought to determine whether CREB-DNA binding was upregulated.
Spec (whether) Positive_regulation (upregulated) of CREB-DNA Spec (whether) Binding (binding) of
8) Confidence 0.34 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.56 Pain Relevance 0.15
B, CREB-DNA binding activity was significantly upregulated when HSPTX was utilized for post-shock resuscitation.
Positive_regulation (upregulated) of CREB-DNA Binding (binding) of associated with shock
9) Confidence 0.34 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.48 Pain Relevance 0.16
Given that an increased association between CBP and CREB was evident with HSPTX, we sought to determine whether CREB-DNA binding was upregulated.
Positive_regulation (increased) of CREB Binding (association) of
10) Confidence 0.34 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.61 Pain Relevance 0.14
B signaling and increased CREB-DNA binding activity.
Positive_regulation (increased) of CREB-DNA Binding (activity) of
11) Confidence 0.31 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2898548 Disease Relevance 0.30 Pain Relevance 0.07
From in vitro assays, we determined that WOX1 blocked the promoter
               activation governed by CREB, CRE, and AP-1, but enhanced the activation by c-Jun,
               Elk-1 and NF-?
Positive_regulation (activation) of CREB Spec (determined) Binding (governed) of
12) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.30 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox