INT87193

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 6
Reported most in Body
Documents 30
Total Number 37
Disease Relevance 29.40
Pain Relevance 9.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnfrsf1b) cell death (Tnfrsf1b) nucleus (Tnfrsf1b)
Anatomy Link Frequency
WBC 4
microglia 2
neuronal 2
plasma 1
bone marrow 1
Tnfrsf1b (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 399 99.92 Very High Very High Very High
withdrawal 12 99.88 Very High Very High Very High
Hippocampus 46 99.68 Very High Very High Very High
Arthritis 144 99.62 Very High Very High Very High
agonist 73 99.22 Very High Very High Very High
chemokine 64 99.16 Very High Very High Very High
cytokine 428 98.96 Very High Very High Very High
Etanercept 103 98.84 Very High Very High Very High
dorsal root ganglion 72 98.84 Very High Very High Very High
Dorsal horn 17 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 128 100.00 Very High Very High Very High
Necrosis 108 100.00 Very High Very High Very High
Adhesions 17 100.00 Very High Very High Very High
Rheumatoid Arthritis 402 99.92 Very High Very High Very High
Arthritis 149 99.84 Very High Very High Very High
Alagille Syndrome 22 99.84 Very High Very High Very High
Toxicity 24 99.58 Very High Very High Very High
Ganglion Cysts 73 98.84 Very High Very High Very High
Neuropathic Pain 11 98.48 Very High Very High Very High
Stress 23 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we investigated local protein levels of the two known TNF receptors, TNF receptor 1 and 2 (TNFR1, TNFR2), on days 0, 1, 3, 7, 14, and 28 after unilateral crush or chronic constriction injury (CCI) of mouse sciatic nerves using enzyme-linked immunoassay.
Spec (investigated) Gene_expression (levels) of TNFR2 in sciatic nerves associated with eae, injury and sciatic nerve
1) Confidence 0.58 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15698630 Disease Relevance 1.10 Pain Relevance 0.48
TNFR1 is expressed in most cell types, and can be activated by binding of either solTNF or tmTNF, with a preference for solTNF; whereas TNFR2 is expressed primarily by cells of the immune system (including microglia) and by endothelial cells, and is preferentially activated by tmTNF [15,16].


Gene_expression (expressed) of TNFR2 in microglia
2) Confidence 0.55 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0 Pain Relevance 0.05
Specifically, it was shown that the absence of TNF resulted in delayed remyelination, depletion of the oligodendrocyte progenitors, and reduction in mature astrocytes after cuprizone withdrawal with TNFR2 expression alone being sufficient to restore oligodendrocyte regeneration [132].
Gene_expression (expression) of TNFR2 in oligodendrocyte associated with withdrawal
3) Confidence 0.55 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.79 Pain Relevance 0.32
receptors, TNFR1 and TNFR2, are expressed in peripheral nerves [16].
Gene_expression (expressed) of TNFR2 in peripheral nerves
4) Confidence 0.54 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.86 Pain Relevance 0.80
TNFR1 is expressed virtually on every cell type except erythrocytes, whereas TNFR2 is mostly expressed on endothelial and bone marrow derived cells [227].
Gene_expression (expressed) of TNFR2 in bone marrow
5) Confidence 0.54 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.54 Pain Relevance 0
Next, we investigated the levels of TNFR1 and TNFR2.
Spec (investigated) Gene_expression (levels) of TNFR2
6) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 0.15 Pain Relevance 0.04
The function of TNF signaling through TNFR1 and TNFR2 in the hippocampus and cortex has not been fully elucidated.
Gene_expression (signaling) of TNFR2 in cortex associated with hippocampus
7) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0 Pain Relevance 0.30
Given the growing evidence that TNFR2 may antagonize TNFR1 signaling, a second strategy, which may bestow beneficial effects and allow protection of neuronal populations highly sensitive to solTNF/TNFR1-mediated toxicity, may be to increase TNFR2 expression levels through gene therapy.
Gene_expression (expression) of TNFR2 in neuronal associated with toxicity
8) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.35 Pain Relevance 0.25
TNFR2-mediated signaling
Gene_expression (signaling) of TNFR2-mediated
9) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.72 Pain Relevance 0.08
Given the growing evidence that TNFR2 may antagonize TNFR1 signaling, a second strategy, which may bestow beneficial effects and allow protection of neuronal populations highly sensitive to solTNF/TNFR1-mediated toxicity, may be to increase TNFR2 expression levels through gene therapy.
Gene_expression (antagonize) of TNFR2 in neuronal associated with toxicity
10) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.38 Pain Relevance 0.27
The TNFR2 activates NF-?
Gene_expression (The) of TNFR2
11) Confidence 0.47 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.54 Pain Relevance 0
receptor II (p75) were determined using a commercial ELISA kit (Quantikine, R&D Systems, Minneapolis, MN).
Spec (determined) Gene_expression (determined) of p75
12) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.20 Pain Relevance 0.06
TNF receptor 1 (TNFR1) is expressed in most cell types, and can be activated by binding of either soluble TNF (solTNF) or transmembrane TNF (tmTNF), with a preference for solTNF; whereas TNFR2 is expressed primarily by microglia and endothelial cells and is preferentially activated by tmTNF.
Gene_expression (expressed) of TNFR2 in endothelial cells
13) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2577641 Disease Relevance 0.91 Pain Relevance 0.11
1-agonist on pure OGD and in hippocampal slices devoid of TNFR1 and TNFR2
Gene_expression (devoid) of TNFR2 associated with agonist
14) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 0.14 Pain Relevance 0.05
through TNFR1 and TNFR2, respectively.
Gene_expression (through) of TNFR2
15) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 0.33 Pain Relevance 0.37
By use of a cytokine/chemokine antibody array it was shown that urinary levels of VCAM-1, sTNFR-1, CXCL16, and P-selectin correlated well with the degree of nephritis in SLE patients [120].
Gene_expression (levels) of sTNFR-1 associated with chemokine, nephritis, systemic lupus erythematosus and cytokine
16) Confidence 0.41 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.35 Pain Relevance 0.24
Expression of soluble TNF receptor II (sTNFRII) parallels TNF-?
Gene_expression (Expression) of sTNFRII
17) Confidence 0.41 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.62 Pain Relevance 0.60
Later studies localized TNFR2 expression exclusively in non-neuronal DRG cells after lipopolysaccharide (LPS) treatment [17] or after inflammation induced by complete Freund's adjuvant (CFA) [18].
Gene_expression (expression) of TNFR2 in DRG associated with dorsal root ganglion and inflammation
18) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2936303 Disease Relevance 1.99 Pain Relevance 1.30
, while TNFR2 is expressed in cells of the immune system and responds to the membrane-bound form of TNF-?.
Gene_expression (expressed) of TNFR2 in immune system
19) Confidence 0.33 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721383 Disease Relevance 1.38 Pain Relevance 0.21
Serum levels of sTNFRII were elevated up to 12 years prior to RA symptoms and were positively associated with incident RA.
Gene_expression (levels) of sTNFRII associated with rheumatoid arthritis
20) Confidence 0.32 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.59 Pain Relevance 0.57

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