INT87199

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.66
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B-cell 1
MALT 1
bone marrow 1
PSS (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 1 99.36 Very High Very High Very High
corticosteroid 4 98.52 Very High Very High Very High
antagonist 6 88.64 High High
withdrawal 2 86.04 High High
Pain 4 85.76 High High
pain pelvic 2 78.96 Quite High
Prostatitis 2 78.16 Quite High
palliative 2 57.68 Quite High
Sicca syndrome 8 50.00 Quite Low
rheumatoid arthritis 4 41.72 Quite Low
Disease Link Frequency Relevance Heat
Leukopenia 8 99.92 Very High Very High Very High
Thrombosis 2 99.90 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 4 99.14 Very High Very High Very High
Disease 61 98.80 Very High Very High Very High
Thrombosis Related Under Development 4 98.58 Very High Very High Very High
Thrombocytopenia 10 97.54 Very High Very High Very High
Syndrome 46 97.44 Very High Very High Very High
Anaemia 4 94.32 High High
Pressure And Volume Under Development 4 93.68 High High
Lymphoproliferative Disease 2 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The thrombocytosis was associated with an increased risk of perioperative thrombosis and decreased PSS.
Negative_regulation (decreased) of PSS associated with thrombosis related under development and thrombosis
1) Confidence 0.50 Published 2000 Journal Blood Section Abstract Doc Link 10733489 Disease Relevance 1.48 Pain Relevance 0.06
Among preoperative variables, thrombocytopenia (platelet count less than 100 x 10(9/)L) and nonhypercellular bone marrow were identified as independent risk factors for decreased PSS.
Negative_regulation (decreased) of PSS in bone marrow associated with thrombocytopenia
2) Confidence 0.50 Published 2000 Journal Blood Section Abstract Doc Link 10733489 Disease Relevance 1.28 Pain Relevance 0
Combined analysis showed a significant reduction of total NIH-CPSI or I-PSS in patients with treatment duration of more than 3 months.
Negative_regulation (reduction) of PSS
3) Confidence 0.42 Published 2006 Journal J. Androl. Section Abstract Doc Link 16870951 Disease Relevance 0.39 Pain Relevance 0.48
However, in pSS there was a substantial decrease in LF HRV (P = 0.024; Figure 2e).
Negative_regulation (decrease) of pSS
4) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453776 Disease Relevance 0 Pain Relevance 0.04
There was a trend toward decreased HRV in pSS relative to control individuals in all three measures, but only the pNN50 frequency was significant (P = 0.025; Figure 2c).
Negative_regulation (decreased) of pSS
5) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453776 Disease Relevance 0.31 Pain Relevance 0
The remaining MALT/pSS patient had progressive MALT disease and severe extraglandular SS disease within 3 months after the start of rituximab treatment.
Negative_regulation (remaining) of pSS in MALT associated with syndrome and disease
6) Confidence 0.13 Published 2007 Journal Clin Rev Allergy Immunol Section Body Doc Link PMC2071970 Disease Relevance 0.97 Pain Relevance 0
Leukopenia in pSS has been shown to be reversed by immunosuppressive treatment with corticosteroids or hydroxychloroquine [29].
Negative_regulation (reversed) of pSS associated with corticosteroid and leukopenia
7) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246233 Disease Relevance 0.52 Pain Relevance 0.05
It has been suggested that reduction of B-cell hyperactivity with immunosuppressants might be the best prevention of lymphoproliferation in pSS [24].
Negative_regulation (prevention) of pSS in B-cell associated with attention deficit hyperactivity disorder
8) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246233 Disease Relevance 0.58 Pain Relevance 0
This down-regulation of DSS and increased PSS was blocked by protein kinase C inhibition and SRPK1/2 inhibition.
Negative_regulation (regulation) of PSS associated with kinase c
9) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2820781 Disease Relevance 0.07 Pain Relevance 0.05

General Comments

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