INT87210

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 3.89
Pain Relevance 4.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
osteoclast 4
Nfkbia (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 688 99.80 Very High Very High Very High
Locus ceruleus 4 99.20 Very High Very High Very High
Inflammation 162 99.08 Very High Very High Very High
Inflammatory response 21 98.80 Very High Very High Very High
antagonist 24 97.44 Very High Very High Very High
cytokine 7 94.84 High High
withdrawal 36 93.44 High High
Eae 28 88.24 High High
Hippocampus 12 86.72 High High
interstitial cystitis 3 86.68 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 334 99.70 Very High Very High Very High
INFLAMMATION 198 99.08 Very High Very High Very High
Injury 18 93.64 High High
Interstitial Cystitis 3 86.68 High High
Drug Dependence 48 85.20 High High
Shock 32 78.84 Quite High
Fibrosis 1 75.00 Quite High
Lung Injury 1 75.00 Quite High
Adhesions 10 70.16 Quite High
Stress 12 65.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluoxetine-treated osteoclast precursors had reduced NF-kappa B activation and elevated inhibitory protein kappa B alpha (I kappa B alpha) levels compared with untreated cells. 5-HT, on the other hand, resulted in activation of NF-kappa B.
Positive_regulation (elevated) of kappa B alpha in osteoclast
1) Confidence 0.61 Published 2004 Journal J. Bone Miner. Res. Section Body Doc Link 15312242 Disease Relevance 0 Pain Relevance 0
Fluoxetine-treated osteoclast precursors had reduced NF-kappa B activation and elevated inhibitory protein kappa B alpha (I kappa B alpha) levels compared with untreated cells. 5-HT, on the other hand, resulted in activation of NF-kappa B.
Positive_regulation (activation) of kappa B alpha in osteoclast
2) Confidence 0.61 Published 2004 Journal J. Bone Miner. Res. Section Body Doc Link 15312242 Disease Relevance 0 Pain Relevance 0
Prior administration of RU486 blocked morphine-produced induction of Tsc22d3, Zbtb16, and Nfkbia mRNAs.
Positive_regulation (induction) of Nfkbia associated with morphine
3) Confidence 0.56 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.05 Pain Relevance 0.69
Fluoxetine-treated osteoclast precursors had reduced NF-kappa B activation and elevated inhibitory protein kappa B alpha (I kappa B alpha) levels compared with untreated cells. 5-HT, on the other hand, resulted in activation of NF-kappa B.
Positive_regulation (elevated) of I kappa B alpha in osteoclast
4) Confidence 0.41 Published 2004 Journal J. Bone Miner. Res. Section Body Doc Link 15312242 Disease Relevance 0 Pain Relevance 0
Fluoxetine-treated osteoclast precursors had reduced NF-kappa B activation and elevated inhibitory protein kappa B alpha (I kappa B alpha) levels compared with untreated cells. 5-HT, on the other hand, resulted in activation of NF-kappa B.
Positive_regulation (activation) of I kappa B alpha in osteoclast
5) Confidence 0.41 Published 2004 Journal J. Bone Miner. Res. Section Body Doc Link 15312242 Disease Relevance 0 Pain Relevance 0
Furthermore, alterations in expression of Sgk and Nfkbia were also observed after acute administration of ethanol [43-45].
Positive_regulation (alterations) of Nfkbia
6) Confidence 0.40 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.22 Pain Relevance 0.75
Within this group, we also highlight nfkbia, which encodes IkappaB-alpha, an inhibitor of the NF-kappaB cascade [51,52].
Positive_regulation (highlight) of nfkbia
7) Confidence 0.38 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.95 Pain Relevance 0.40
Uniquely in the C57BL/6J strain, abundance of Nfkbia mRNA was increased almost twofold after acute morphine compared with control.
Positive_regulation (increased) of Nfkbia associated with sprains and strains and morphine
8) Confidence 0.37 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.71 Pain Relevance 0.42
Moreover, transcriptional activation of a pattern of co-expressed genes (for instance, Tsc22d3 and Nfkbia) was identified as being mediated via the glucocorticoid receptor (GR).
Positive_regulation (activation) of Nfkbia
9) Confidence 0.37 Published 2007 Journal Genome Biol Section Abstract Doc Link PMC2394777 Disease Relevance 0.47 Pain Relevance 1.18
Treatment with taurine and niacin generally inhibited the BL-induced increases in the nuclear localization of NF-kappaB and preserved IkappaBalpha protein in BL + TN groups.
Positive_regulation (increases) of IkappaBalpha
10) Confidence 0.37 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.15 Pain Relevance 0.16
In this context, the activation of genes such as dusp1 and nfkbia seems to counter-balance the inflammatory response to PAR activation by limiting prolonged activation of p38 MAPK and increased cytokine production.
Positive_regulation (activation) of nfkbia associated with inflammatory response and cytokine
11) Confidence 0.36 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1853107 Disease Relevance 0.90 Pain Relevance 0.55
In this context, the activation of genes such as dusp1 and nfkbia seems to counter balance the inflammatory response to PAR activation by avoiding prolonged activation of p38 MAPK and increased cytokine production [68].
Positive_regulation (activation) of nfkbia associated with inflammatory response and cytokine
12) Confidence 0.36 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.44 Pain Relevance 0.21

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