INT87211

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 15.84
Pain Relevance 5.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
nucleus 8
ganglion cell layer 6
brain 4
urinary bladder 2
sciatic nerves 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 90 100.00 Very High Very High Very High
substance P 66 99.98 Very High Very High Very High
Sciatic nerve 2 99.68 Very High Very High Very High
Inflammatory mediators 22 99.28 Very High Very High Very High
Inflammation 249 98.04 Very High Very High Very High
Neuritis 5 97.60 Very High Very High Very High
cINOD 29 95.84 Very High Very High Very High
Antinociceptive 4 95.48 Very High Very High Very High
chemokine 11 95.32 Very High Very High Very High
COX-2 inhibitor 4 94.96 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 66 100.00 Very High Very High Very High
Hemophilus Infection 89 99.84 Very High Very High Very High
INFLAMMATION 322 99.28 Very High Very High Very High
Cancer 68 99.24 Very High Very High Very High
Necrosis 17 98.96 Very High Very High Very High
Experimental Autoimmune Neuritis 5 98.56 Very High Very High Very High
Ganglion Cysts 8 98.52 Very High Very High Very High
Disease 214 98.20 Very High Very High Very High
Apoptosis 183 98.12 Very High Very High Very High
Hypersensitivity 7 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine also significantly enhanced LPS-induced NF-kappaB activation by enhancing the nuclear translocation of NF-kappaB as well as increasing the NF-kappaB-DNA binding activity.
Positive_regulation (enhancing) of Localization (translocation) of NF-kappaB
1) Confidence 0.59 Published 2008 Journal J. Surg. Res. Section Body Doc Link 18262561 Disease Relevance 0 Pain Relevance 0
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Positive_regulation (induced) of Localization (translocation) of NF-kappaB associated with necrosis and cancer
2) Confidence 0.49 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.52 Pain Relevance 0.24
The effect of ME10092 treatment (1-100 pmol/mouse) on nuclear translocation of NF-kappaB, activation of expression of inflammatory mediators and production of nitric oxide were measured in the lipopolysaccharide (LPS)-induced brain inflammation model in mice in vivo.
Positive_regulation (activation) of Localization (translocation) of NF-kappaB in brain associated with inflammatory mediators, inflammation and encephalitis
3) Confidence 0.49 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.41 Pain Relevance 0.22
Treatment with taurine and niacin generally inhibited the BL-induced increases in the nuclear localization of NF-kappaB and preserved IkappaBalpha protein in BL + TN groups.
Positive_regulation (increases) of Localization (localization) of NF-kappaB
4) Confidence 0.48 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.15 Pain Relevance 0.16
Our present findings using EMSA and ChIP-Q-PCR confirmed that both the mouse urinary and the J82 urothelial cancer cell line respond to BCG treatment with an increased translocation of NF-kappaB.
Positive_regulation (increased) of Localization (translocation) of NF-kappaB in J82 associated with cancer
5) Confidence 0.46 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.42 Pain Relevance 0
, and Toll-like receptors lead to the release of p50:cRel and p50:relA dimers through the classic pathway.
Positive_regulation (lead) of Localization (release) of p50
6) Confidence 0.40 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.34 Pain Relevance 0.10
The activation of ERK pathway and subsequent translocation of NF-kappaB was possibly necessary for the up-regulation TRPC6 induced by Ang II.
Spec (possibly) Positive_regulation (necessary) of Localization (translocation) of NF-kappaB
7) Confidence 0.40 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.51 Pain Relevance 0.03
Furthermore, our data also demonstrated that the translocation of NF-kappaB activated by LPS into the nucleus was suppressed by menthone, and I-kappaB and beta-transducin repeat containing protein (beta-TrCP) were both involved in this suppression.
Positive_regulation (activated) of Localization (translocation) of NF-kappaB in nucleus
8) Confidence 0.37 Published 2008 Journal Chin J Physiol Section Abstract Doc Link 18935911 Disease Relevance 0.66 Pain Relevance 0.29
Intravesical instillation of SP stimulates NF-kappaB and Nkx-2.5 translocation in the bladder mucosa
Positive_regulation (stimulates) of Localization (translocation) of NF-kappaB in bladder associated with substance p
9) Confidence 0.33 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
degradation as well as increased nuclear localization of NF-kB p65 in the lung at 18 h after zymosan administration.
Positive_regulation (increased) of Localization (localization) of NF-kB in lung
10) Confidence 0.32 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 1.31 Pain Relevance 0.34
In our model, we observed increased mRNA for both p65 and p50, but only the p65 protein exhibited prominent accumulation in microglia.
Positive_regulation (increased) of Localization (mRNA) of p50 in microglia
11) Confidence 0.31 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0
EMSA analysis showed that NF-kappa B translocation and its DNA binding activity were markedly increased by NTHi within 90 mins, and DNA binding activity of NF-kappa B was not affected by pre-treatment of specific p38 MAPK inhibitor SB203580.
Positive_regulation (increased) of Localization (translocation) of NF-kappa B associated with hemophilus infection
12) Confidence 0.30 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.29 Pain Relevance 0
METHODS: C. racemosa rhizome and phosphate-buffered saline extracts were analysed for phenolcarboxylic acids and triterpene glycosides using an HPLC photodiode array/evaporative light-scattering detector system. iNOS was characterised by measurement of iNOS protein (immunoblotting), iNOS mRNA (semiquantitative competitive RT-PCR), nitric oxide production (nitrite levels) and nuclear translocation of nuclear factor-kappaB (p65 subunit) protein.
Positive_regulation (measurement) of Localization (translocation) of nuclear factor-kappaB
13) Confidence 0.29 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703353 Disease Relevance 0 Pain Relevance 0
All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.
Positive_regulation (induced) of Localization (translocation) of p50 in ganglion cell layer associated with ganglion cysts and diabetes mellitus
14) Confidence 0.24 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.36 Pain Relevance 0.24
Indeed, in the urinary bladder, activation of NK1R by SP induces NF-kappaB translocation, as seen by EMSA results (Figure 9), and up-regulation of pro-inflammatory genes, such as the encoding prostaglandin I2 receptor (Figure 6).
Positive_regulation (induces) of Localization (translocation) of NF-kappaB in urinary bladder associated with inflammation and substance p
15) Confidence 0.24 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.55 Pain Relevance 0.28
Next, we used EMSA to confirm that selected TREs (NF-kappaB and NKx-2.5) are indeed part of the molecular network downstream of NK1R activation.
Positive_regulation (activation) of Localization (selected) of NF-kappaB
16) Confidence 0.24 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.14 Pain Relevance 0.06
Immunolocalization and activation of nuclear factor-kappaB in the sciatic nerves of rats with experimental autoimmune neuritis.
Positive_regulation (activation) of Localization (Immunolocalization) of nuclear factor-kappaB in sciatic nerves associated with experimental autoimmune neuritis, sciatic nerve and neuritis
17) Confidence 0.19 Published 2006 Journal J. Neuroimmunol. Section Title Doc Link 16516982 Disease Relevance 0.53 Pain Relevance 0.51
All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.
Positive_regulation (diabetes-induced) of Localization (translocation) of p50 in ganglion cell layer associated with ganglion cysts and diabetes mellitus
18) Confidence 0.18 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.41 Pain Relevance 0.24
It is possible that SC236 directly targets proteins that facilitate the nuclear translocation of NF-kappaB.
Positive_regulation (facilitate) of Localization (translocation) of NF-kappaB
19) Confidence 0.11 Published 2003 Journal Oncogene Section Abstract Doc Link 12606945 Disease Relevance 0.33 Pain Relevance 0.25
Thirty minutes after fatty acid addition, we found a significant 3-fold increase in translocation of NF-kappaB transcription factor to the nucleus.
Positive_regulation (increase) of Localization (translocation) of NF-kappaB in nucleus
20) Confidence 0.11 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16452198 Disease Relevance 0.26 Pain Relevance 0.27

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