INT87212

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 74
Total Number 75
Disease Relevance 38.21
Pain Relevance 28.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
nucleus 12
macrophages 8
spinal cord 6
neutrophil 6
plasma 4
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 417 100.00 Very High Very High Very High
cytokine 56 100.00 Very High Very High Very High
Inflammatory mediators 19 100.00 Very High Very High Very High
Kinase C 17 100.00 Very High Very High Very High
qutenza 98 99.98 Very High Very High Very High
cINOD 51 99.98 Very High Very High Very High
COX-2 inhibitor 15 99.98 Very High Very High Very High
licofelone 10 99.98 Very High Very High Very High
diclofenac 4 99.98 Very High Very High Very High
tramadol 2 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 448 100.00 Very High Very High Very High
Apoptosis 179 100.00 Very High Very High Very High
Cancer 51 100.00 Very High Very High Very High
Necrosis 33 100.00 Very High Very High Very High
Myocardial Infarction 4 100.00 Very High Very High Very High
Fibrosis 3 99.92 Very High Very High Very High
Pressure And Volume Under Development 73 99.90 Very High Very High Very High
Colon Cancer 4 99.84 Very High Very High Very High
Stomach Cancer 3 99.84 Very High Very High Very High
Lung Injury 22 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.
Negative_regulation (suppressed) of Positive_regulation (activation) of NF-kappaB in skin associated with qutenza
1) Confidence 0.57 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.19 Pain Relevance 0.57
Although we have shown in a previous study the therapeutic effect of lornoxicam on corneal damage after high intensity UVB irradiation via inhibition of NF-kB activation, the concrete mediators and detailed mechanisms between NF-?
Negative_regulation (inhibition) of Positive_regulation (activation) of NF-kB
2) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2697669 Disease Relevance 0.65 Pain Relevance 0.03
S. pneumoniae infection resulted in a significant induction of NF-kappaB activity only in TLR9 stably transfected HEK 293 cells, but not in TLR2 and TLR4 transfected HEK 293 cells, and morphine treatment inhibited S. pneumoniae-induced NF-kappaB activity in these cells.
Negative_regulation (inhibited) of Positive_regulation (induced) of NF-kappaB associated with infection and morphine
3) Confidence 0.57 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18292587 Disease Relevance 0.73 Pain Relevance 0.59
The extract also suppressed increases in nuclear factor-kappaB (NF-kappaB) levels in the nucleus.
Negative_regulation (suppressed) of Positive_regulation (increases) of nuclear factor-kappaB in nucleus
4) Confidence 0.55 Published 2009 Journal J Med Food Section Abstract Doc Link 19735178 Disease Relevance 0.30 Pain Relevance 0.54
These results suggested that DHCD inhibited NO generation by blocking NF-kappaB activation and iNOS gene transcription.
Negative_regulation (blocking) of Positive_regulation (activation) of NF-kappaB
5) Confidence 0.53 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14752064 Disease Relevance 0.08 Pain Relevance 0.17
Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-kappaB in mice.
Negative_regulation (down-regulating) of Positive_regulation (activation) of nuclear factor-kappaB in lung associated with lung injury and fibrosis
6) Confidence 0.49 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10734156 Disease Relevance 0.39 Pain Relevance 0.20
NS-398 treatment also attenuated COX-2 mRNA levels and NF-kappaB activation.
Negative_regulation (attenuated) of Positive_regulation (activation) of NF-kappaB
7) Confidence 0.47 Published 2001 Journal J. Surg. Res. Section Abstract Doc Link 11368536 Disease Relevance 0.56 Pain Relevance 0.45
Furthermore, siegeskaurolic acid inhibited the nuclear factor-kappaB (NF-kappaB) activation induced by LPS, and this was associated with the prevention of inhibitor kappaB degradation (I kappaB), and subsequently with decreased nuclear p65 and p50 protein levels.
Negative_regulation (inhibited) of Positive_regulation (activation) of NF-kappaB
8) Confidence 0.46 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17207792 Disease Relevance 0.51 Pain Relevance 0.29
Of the compounds that are known to be NF-kappaB antagonists, the most practical for current use may be the nonsteroidal anti-inflammatory drugs aspirin, salicylic acid, and sulindac, each of which binds to and inhibits Ikappa kinase- beta, a central mediator of NF-kappa activation; the low millimolar plasma concentrations of salicylate required for effective inhibition of this kinase in vivo can be achieved with high-dose regimens traditionally used to manage rheumatic disorders.
Negative_regulation (inhibits) of Positive_regulation (activation) of NF-kappa in plasma associated with aspirin, inflammation, antagonist and cinod
9) Confidence 0.42 Published 2006 Journal Integr Cancer Ther Section Abstract Doc Link 16880431 Disease Relevance 0.65 Pain Relevance 0.23
We recently reported that APAP likewise inhibits serum growth factor activation of NF-kappaB in a mouse hepatoma cell line (Hepa 1-6 cells).
Negative_regulation (inhibits) of Positive_regulation (activation) of NF-kappaB in Hepa 1-6 associated with paracetamol and hepatocellular cancer
10) Confidence 0.42 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10828269 Disease Relevance 0.19 Pain Relevance 0.74
The extract also suppressed increases in nuclear factor-kappaB (NF-kappaB) levels in the nucleus.
Negative_regulation (suppressed) of Positive_regulation (increases) of NF-kappaB in nucleus
11) Confidence 0.40 Published 2009 Journal J Med Food Section Abstract Doc Link 19735178 Disease Relevance 0.30 Pain Relevance 0.54
Glutathione depletion by DEM or APAP was associated with inhibition of TNF-induced NF-kappaB transactivation of anti-apoptotic genes, including inducible nitric oxide synthase (i-NOS).
Negative_regulation (inhibition) of Positive_regulation (transactivation) of NF-kappaB associated with paracetamol and apoptosis
12) Confidence 0.39 Published 2003 Journal Hepatology Section Abstract Doc Link 12774022 Disease Relevance 0.88 Pain Relevance 0.34
DHCD potently blocked nuclear factor-kappaB (NF-kappaB) activation, a process necessary for transcriptional activation of iNOS.
Negative_regulation (blocked) of Positive_regulation (activation) of NF-kappaB
13) Confidence 0.39 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14752064 Disease Relevance 0.08 Pain Relevance 0.15
Activation of the inflammatory transcription factor, nuclear factor-kappaB (NF-kappaB) was inhibited significantly in Hsp Tg mice and microglia.
Negative_regulation (inhibited) of Positive_regulation (Activation) of nuclear factor-kappaB in microglia associated with inflammation
14) Confidence 0.39 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.98 Pain Relevance 0.30
Thus, our study suggests that the inhibitions of iNOS, COX-2 expression, and TNF-alpha release by the methanol extract of the semen of Xanthium strumarium L. are achieved by blocking NF-kappaB activation, and that this is also responsible for its anti-inflammatory effects.
Negative_regulation (blocking) of Positive_regulation (activation) of NF-kappaB in semen associated with inflammation
15) Confidence 0.38 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15635170 Disease Relevance 0.62 Pain Relevance 0.22
Furthermore, Cardiospermum halicacabum L. ethanol extract inhibited the TNF-alpha induced DNA binding activity of NF-kappaB, which was associated with decreased p65 protein level in the nucleus in Jurkat cells.
Negative_regulation (inhibited) of Positive_regulation (induced) of NF-kappaB in nucleus
16) Confidence 0.38 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19393729 Disease Relevance 0.06 Pain Relevance 0
PEA attenuated the development of carrageenan-induced paw edema, we evaluated inhibitor kappaB-alpha (I kappa B-alpha) degradation and nuclear factor-kappaB (NF-kappaB) p65 activation in the cytosolic or nuclear extracts from spinal cord tissue.
Negative_regulation (evaluated) of Positive_regulation (activation) of NF-kappaB in spinal cord associated with pressure and volume under development and spinal cord
17) Confidence 0.37 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.53 Pain Relevance 0.56
It also inhibited NF-kappaB activation in vivo in TPO(high) mice leading to decreased IL-1alpha plasma levels.
Negative_regulation (inhibited) of Positive_regulation (activation) of NF-kappaB in plasma
18) Confidence 0.35 Published 2007 Journal Blood Section Abstract Doc Link 17374740 Disease Relevance 1.03 Pain Relevance 0.24
Furthermore, siegeskaurolic acid inhibited the nuclear factor-kappaB (NF-kappaB) activation induced by LPS, and this was associated with the prevention of inhibitor kappaB degradation (I kappaB), and subsequently with decreased nuclear p65 and p50 protein levels.
Negative_regulation (inhibited) of Positive_regulation (activation) of nuclear factor-kappaB
19) Confidence 0.34 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17207792 Disease Relevance 0.51 Pain Relevance 0.29
Treatment of malignant melanoma cells with the H(2)O(2) scavenger catalase, the sulfhydryl donor N-acetylcysteine, the glutathione peroxidase mimetic ebselen, or dicumarol decreased NF-kappaB activation.
Negative_regulation (decreased) of Positive_regulation (activation) of NF-kappaB associated with skin cancer
20) Confidence 0.33 Published 2001 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 11171586 Disease Relevance 0.53 Pain Relevance 0.18

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