INT87214

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 5.85
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
lungs 4
macrophages 2
lung epithelium 2
skin 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 6 99.16 Very High Very High Very High
Paracetamol 1 96.40 Very High Very High Very High
sodium channel 7 94.48 High High
cytokine 10 92.60 High High
Inflammation 71 92.20 High High
ketamine 2 88.96 High High
alcohol 2 88.76 High High
Inflammatory mediators 8 87.60 High High
anesthesia 4 87.20 High High
Analgesic 1 78.72 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 21 100.00 Very High Very High Very High
Cancer 11 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Hemophilus Infection 178 98.40 Very High Very High Very High
Skin Cancer 2 98.28 Very High Very High Very High
Diabetes Mellitus 273 97.12 Very High Very High Very High
Targeted Disruption 35 93.24 High High
Stress 137 92.36 High High
INFLAMMATION 84 92.20 High High
Cardiovascular Disease 7 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of taurine (T) and niacin (N) on bleomycin (BL)-induced increased production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1alpha, IL-6, and transforming growth factor-beta (TGF-beta) levels in the bronchoalveolar lavage fluid (BALF), and increased collagen content and nuclear factor-kappaB (NF-kappaB) activation in the lungs were investigated in mice.
Spec (investigated) Regulation (effects) of Positive_regulation (activation) of nuclear factor-kappaB in lungs associated with necrosis and cancer
1) Confidence 0.43 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.35 Pain Relevance 0.20
The effects of taurine (T) and niacin (N) on bleomycin (BL)-induced increased production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1alpha, IL-6, and transforming growth factor-beta (TGF-beta) levels in the bronchoalveolar lavage fluid (BALF), and increased collagen content and nuclear factor-kappaB (NF-kappaB) activation in the lungs were investigated in mice.
Spec (investigated) Regulation (effects) of Positive_regulation (increased) of NF-kappaB in lungs associated with necrosis and cancer
2) Confidence 0.43 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.35 Pain Relevance 0.19
These data demonstrate that lignocaine has significant inhibitory effects on the activation of TLR-4, NF-kappaB and MAPKs in activated macrophages.
Regulation (effects) of Positive_regulation (activation) of NF-kappaB in macrophages
3) Confidence 0.34 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18505446 Disease Relevance 0 Pain Relevance 0.29
The findings in the present study clearly demonstrate that the activation of p38 MAPK and NF-kappa B is involved in the regulation of COX-2 and PGE2 in NTHi-infected lung epithelium.
Regulation (involved) of Positive_regulation (activation) of NF-kappa B in lung epithelium associated with hemophilus infection
4) Confidence 0.27 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.81 Pain Relevance 0.08
Since altered transactivation of NF-kappaB and AP-1 has been implicated for neoplastic transformation and progression, the suppression of these transcription factors by capsaicin may account for its previously reported chemopreventive effects on mouse skin tumorigenesis as well as inflammation.
Regulation (altered) of Positive_regulation (transactivation) of NF-kappaB in skin associated with inflammation and qutenza
5) Confidence 0.26 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.25 Pain Relevance 0.59
In addition, there exists an auto-regulation of NF-kappa B activation: NF-kappa B is essential for induction of cylindromatosis (CYLD) that in turn inhibits NF-kappa B signaling [20].
Regulation (regulation) of Positive_regulation (activation) of NF-kappa B associated with skin cancer
6) Confidence 0.20 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.10 Pain Relevance 0.14
Carprofen and, to a lesser degree, flunixin meglumine had inhibitory effects on NFkappaB activation.
Regulation (effects) of Positive_regulation (activation) of NFkappaB
7) Confidence 0.07 Published 2003 Journal Am. J. Vet. Res. Section Body Doc Link 12602591 Disease Relevance 0 Pain Relevance 0
Intracellular and tissue levels of GPX1 activity affect apoptotic signaling pathway, protein kinase phosphorylation, and oxidant-mediated activation of NFkappaB.
Regulation (affect) of Positive_regulation (activation) of NFkappaB associated with apoptosis
8) Confidence 0.04 Published 2007 Journal Annu. Rev. Nutr. Section Abstract Doc Link 17465855 Disease Relevance 0.98 Pain Relevance 0.13
Ceramide can be formed in these cells by direct de novo synthesis from FFAs. [72] Ceramide is responsible for the induction and activation of NFkappa B. [78]
Regulation (responsible) of Positive_regulation (induction) of NFkappa B
9) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.00 Pain Relevance 0.08
Ceramide can be formed in these cells by direct de novo synthesis from FFAs. [72] Ceramide is responsible for the induction and activation of NFkappa B. [78]
Regulation (responsible) of Positive_regulation (activation) of NFkappa B
10) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.00 Pain Relevance 0.08

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