INT87233

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.54
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ECE1) peptidase activity (ECE1) plasma membrane (ECE1)
Anatomy Link Frequency
endothelial cells 2
myocardium 1
cortex 1
central nervous system 1
hippocampus 1
ECE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 3 100.00 Very High Very High Very High
Central nervous system 14 99.68 Very High Very High Very High
Neurotransmitter 12 98.72 Very High Very High Very High
Hippocampus 2 98.64 Very High Very High Very High
Neuropeptide 6 97.40 Very High Very High Very High
metalloproteinase 2 86.32 High High
cytokine 10 84.36 Quite High
Enkephalin 2 76.32 Quite High
substance P 2 75.28 Quite High
Inflammatory response 4 71.04 Quite High
Disease Link Frequency Relevance Heat
Injury 8 99.20 Very High Very High Very High
Increased Venous Pressure Under Development 7 99.18 Very High Very High Very High
Sprains And Strains 15 98.60 Very High Very High Very High
Infection 28 97.06 Very High Very High Very High
Targeted Disruption 22 96.20 Very High Very High Very High
Amyloid Plaque 14 95.64 Very High Very High Very High
Heart Disease 12 92.64 High High
Disease 110 91.32 High High
Protozoal Infection 6 87.68 High High
Eclampsia 2 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The infection of CD1 mice with the Brazil strain and C57BL/6 mice with the Tulahuen strain caused an intense vasculitis, high plasma ET-1 levels, and increased expression of mRNAs for the precursor molecule preproET-1, endothelin converting enzyme (ECE), and ET-1 in the myocardium [76].
Gene_expression (expression) of ECE in myocardium associated with increased venous pressure under development, sprains and strains and infection
1) Confidence 0.65 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 1.31 Pain Relevance 0.24
By immunohistochemical analysis and immunofluorescence, endothelin-converting enzyme-1 (ECE-1), the enzyme that synthesizes ET-1, is localized to five distinct cell populations in the human placenta: (1) the endothelial cells lining the maternal basal plate blood vessels, (2) the intermediate trophoblasts, (3) the endothelial cells lining the chorionic villous blood vessels, (4) the chorionic villous stromal cells and (5) the chorionic villous trophoblasts.
Gene_expression (synthesizes) of ECE-1 in endothelial cells
2) Confidence 0.60 Published 2000 Journal Placenta Section Abstract Doc Link 10736246 Disease Relevance 0.09 Pain Relevance 0
By immunohistochemical analysis and immunofluorescence, endothelin-converting enzyme-1 (ECE-1), the enzyme that synthesizes ET-1, is localized to five distinct cell populations in the human placenta: (1) the endothelial cells lining the maternal basal plate blood vessels, (2) the intermediate trophoblasts, (3) the endothelial cells lining the chorionic villous blood vessels, (4) the chorionic villous stromal cells and (5) the chorionic villous trophoblasts.
Gene_expression (synthesizes) of endothelin-converting enzyme-1 in endothelial cells
3) Confidence 0.60 Published 2000 Journal Placenta Section Abstract Doc Link 10736246 Disease Relevance 0.09 Pain Relevance 0
The level of endothelin-converting enzyme was upregulated at that site where, upon exposure to serotonin, there were also increases in p47(phox), ROS, and ET-1 fluorescence intensities, and myosin light chain phosphorylation and RhoA activation were detected.
Gene_expression (detected) of endothelin-converting enzyme associated with serotonin
4) Confidence 0.12 Published 2009 Journal Coron. Artery Dis. Section Abstract Doc Link 19623039 Disease Relevance 0.69 Pain Relevance 0.20
Recently an ECE-like gene was identified in L. migratoria and was shown to be highly expressed in the central nervous system and the midgut [25].
Gene_expression (expressed) of ECE-like in central nervous system associated with central nervous system
5) Confidence 0.10 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0.26 Pain Relevance 0.15
Interestingly, the ECE-like group of enzymes (ECEL-1, DINE, etc), for which there are no known physiological substrates, are unique in that all have a LNAYY motif, which may influence substrate specificity.
Gene_expression (group) of ECE-like
6) Confidence 0.09 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0 Pain Relevance 0
Though, it is possible that F. rubripes may have lost an ECE-1 gene, the drastic consequences of losing ECE-1 in mammals makes this unlikely.
Gene_expression (losing) of ECE-1
7) Confidence 0.09 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0 Pain Relevance 0
The endothelin converting enzymes (ECE-1 and ECE-2) and the ECE-like group of enzymes all have distinctive biology.
Gene_expression (group) of ECE-1
8) Confidence 0.09 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0.28 Pain Relevance 0.06
Also the genome of another fish, Tetraodon nigroviridis, contains two ECE-like genes and the frog, Xenopus laevis, has an ECE-1 protein, and therefore it is conceivable that the ECE-1 sequence of F. rubripes has yet to be determined.
Gene_expression (sequence) of ECE-1
9) Confidence 0.09 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0 Pain Relevance 0
The endothelin converting enzymes (ECE-1 and ECE-2) and the ECE-like group of enzymes all have distinctive biology.
Gene_expression (group) of ECE-like
10) Confidence 0.08 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0.27 Pain Relevance 0.06
Recently, Carty et al. used recombinant adeno-associated virus (rAAV) to over-express ECE in the right anterior cortex and hippocampus of mice, resulting in A?
Gene_expression (express) of ECE in hippocampus associated with hippocampus
11) Confidence 0.07 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.28 Pain Relevance 0.21
Recently, Carty et al. used recombinant adeno-associated virus (rAAV) to over-express ECE in the right anterior cortex and hippocampus of mice, resulting in A?
Gene_expression (express) of ECE in cortex associated with hippocampus
12) Confidence 0.03 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.28 Pain Relevance 0.21

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