INT87235

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 54
Total Number 55
Disease Relevance 31.51
Pain Relevance 13.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cells 4
eosinophil 2
lymph node 1
plasma 1
macrophages 1
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1131 100.00 Very High Very High Very High
Inflammation 1063 100.00 Very High Very High Very High
Inflammatory mediators 22 100.00 Very High Very High Very High
agonist 29 99.60 Very High Very High Very High
dexamethasone 24 99.48 Very High Very High Very High
antagonist 270 98.84 Very High Very High Very High
Arthritis 291 98.80 Very High Very High Very High
Morphine 35 98.18 Very High Very High Very High
Paracetamol 7 97.56 Very High Very High Very High
anesthesia 24 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1103 100.00 Very High Very High Very High
Asthma 798 100.00 Very High Very High Very High
Hyperplasia 127 100.00 Very High Very High Very High
Diabetes Mellitus 38 99.84 Very High Very High Very High
Rhinitis 67 99.56 Very High Very High Very High
Atherosclerosis 46 99.52 Very High Very High Very High
Sprains And Strains 196 99.48 Very High Very High Very High
Systemic Lupus Erythematosus 190 99.48 Very High Very High Very High
Colitis 46 99.44 Very High Very High Very High
Spontaneous Abortion 36 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding is consistent with that observed in response to infestation with I. scapularis nymphs where IL-4 polarizing potential was partially reduced during secondary infestation [22].
Negative_regulation (reduced) of IL-4
1) Confidence 0.48 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.15 Pain Relevance 0
were found in LPS-induced abortion mice, while the Th2 type cytokine IL-4 levels were decreased significantly when injected with LPS on day 7 of pregnancy.
Negative_regulation (decreased) of IL-4 associated with spontaneous abortion and cytokine
2) Confidence 0.46 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.54 Pain Relevance 0.25
To date, no studies have been able to demonstrate in vivo the effect of a cell-specific inhibition of the IL-13/IL-4R?
Negative_regulation (inhibition) of IL-4
3) Confidence 0.42 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.88 Pain Relevance 0.12
mice and a transient reduction of goblet cell hyperplasia in SM-MHCCreIL-4R??
Negative_regulation (reduction) of IL-4 in goblet cell associated with hyperplasia
4) Confidence 0.41 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.73 Pain Relevance 0.06
In cell culture studies, the half-life of phosphorylated STAT-6 after a single bolus dose of IL-4 was less then one hour.
Negative_regulation (dose) of IL-4
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0.18 Pain Relevance 0.05
Consistent down-regulation of critical inflammatory genes in ETS- and doubly OVA-exposed mice was confirmed through qRT-PCR, revealing down-regulation of 17 asthma-related and/or inflammatory genes (Arg1, Ccl8, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Slc7a2, Il4, Il6, Il10, Il13, Il1b, Tnfa).
Negative_regulation (regulation) of Il4 associated with asthma, nicotine addiction and inflammation
6) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.15 Pain Relevance 0.51
The gene for IL-10, which is essential for the eosinophilic inflammation seen in asthma (and in this mouse model), is down-regulated, resulting in decreases in mucus production and eosinophilic inflammation without decreased IgE or IL-4 (Yang et al. 2000).
Neg (without) Negative_regulation (decreased) of IL-4 associated with asthma, rhinitis and inflammation
7) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.14 Pain Relevance 0.48
Deficiency in IL4, IL13 and NRAMP are not sufficient to abrogate this inflammatory process.
Negative_regulation (Deficiency) of IL4 associated with inflammation
8) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.19 Pain Relevance 0.31
In this model, the exposure to morphine (25 mg/kg, 5 days before, during and 5 days after inoculation with the yeast) significant decreased IL-2 and IL-4 levels, while secretion of IFN-gamma was unaltered.
Negative_regulation (decreased) of IL-4 associated with morphine
9) Confidence 0.39 Published 2000 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 10737255 Disease Relevance 0.31 Pain Relevance 0.58
agonists have been shown to reduce IL4, IL5, and IL13 production from Tcells of mice with induced lung inflammation [38,49].
Negative_regulation (reduce) of IL4 in lung associated with inflammation, agonist and pneumonia
10) Confidence 0.36 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.51 Pain Relevance 0.36
CONCLUSIONS: The results demonstrate for the first time that a combination of viral infection and constitutive expression of IL-2, but not IFN-gamma or IL-4, can result in demyelination and visual impairment in the optic nerves of ocularly infected mice.


Negative_regulation (combination) of IL-4 in optic nerves
11) Confidence 0.25 Published 2009 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19234357 Disease Relevance 0.06 Pain Relevance 0
Bv8 10-9 M lowered IL-10 (panel A) and IL-4 concentrations (panel B) in the WT controls in the same way as in the Balb/C mice, but the fact that these effects were completely abolished in the PROKR 1 KO mice demonstrates their dependence on the receptor.
Negative_regulation (lowered) of IL-4 associated with addiction
12) Confidence 0.22 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.10 Pain Relevance 0.21
This effect is confirmed by our in vitro experiments showing that Bv8 also decreases IL-10 and IL-4 levels when added to splenocytes at the time of antigen restimulation.
Negative_regulation (decreases) of IL-4
13) Confidence 0.22 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.07 Pain Relevance 0.10
dramatically increased; whereas IL-4 decreased in rats with colitis compared to the healthy rat.
Negative_regulation (decreased) of IL-4 associated with colitis
14) Confidence 0.22 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840610 Disease Relevance 1.19 Pain Relevance 0.40
decreased IL-4 level which caused reduction in rolling and adhesion of
Negative_regulation (decreased) of IL-4 associated with adhesions
15) Confidence 0.21 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.34 Pain Relevance 0.06
In this previous study decreases in IL-4, IL-5 and IL-13 were also demonstrated in ovalbumin stimulated lymph node cultures from H4R antagonist treated or H4R deficient mice, despite any effect on proliferation.
Negative_regulation (decreases) of IL-4 in lymph node associated with antagonist
16) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.29 Pain Relevance 0.44
Indeed, a functionally relevant reduction in IL-4 was suggested by an observed decrease in antigen-specific IgE observed with H4R antagonist treatment.
Negative_regulation (reduction) of IL-4 associated with antagonist
17) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.20 Pain Relevance 0.35
There was also trend towards a reduction in IL-4 levels.
Negative_regulation (reduction) of IL-4
18) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.23 Pain Relevance 0.33
After 3.5 h of ovalbumin peptide challenge in culture, the levels of IL-4 secreted by Cerk-/- cells was reduced by 30% (p = 0.04) compared to WT cells (Fig. 2).


Negative_regulation (reduced) of IL-4
19) Confidence 0.20 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.51 Pain Relevance 0.22
IL-4 and IL-13; levels of the latter are only partially reduced in absence of CERK; Fig. 1).
Negative_regulation (reduced) of IL-4
20) Confidence 0.20 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.22 Pain Relevance 0.14

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